A molecule
on glioblastoma cells that could be used as a target for genetically engineered immune cells has been identified.
«The cytopathic effects of Zika infection
on glioblastoma cells were observed most clearly after 48 hours.
Not exact matches
Several studies have used
cell - surface markers — proteins found
on the outer membranes of tumor
cells — to identify
glioblastoma stem
cells; but the specific markers used have been controversial and can not reflect molecular processes going
on within tumor
cells.
Invasion assays using
Glioblastoma (GBM)
cells on the left lacking Id4, in comparison to the same
cells being genetically engineered to express Id4
on the right.
Next steps will include engineering T
cells that reliably detect multiple features
on cancers such as mesothelioma and
glioblastoma, allowing for more precise targeting of these diseases.
The screening revealed coibamide A to be capable of killing many types of cancer
cells, but Ishmael decided to focus subsequent studies
on two types in particular — brain tumors, or
glioblastomas, and a breast cancer subtype known as triple negative breast cancer.
It is a continuation of previous research, published in 2011, that focused
on the effect of decitabine
on glioblastoma human
cell cultures.
«By treating
glioblastoma cells with decitabine, we found that we can unmask targets
on the tumor
cell that can be recognized by killer T
cells.
To date, the TCGA Research Network has generated data and published analyses
on glioblastoma multiforme, ovarian serous adenocarcinoma, colorectal adenocarcinoma, lung squamous
cell carcinoma and invasive breast cancer.
His team identified a factor that may be important for clinical trial design: progesterone was not toxic to all
glioblastoma cell lines, and its toxicity may depend
on whether the tumor suppressor gene p53 is mutated.
The findings may even have implications for studying
glioblastoma, a common brain cancer whose ability to grow, migrate and hack into the brain's blood supply appears to rely
on a pattern of gene activity similar to that now identified in these neural stem
cells.
We initially focused
on drilling down into the genetic differences between
glioblastoma tumour stem
cells and normal neural stem
cells.
Nigericin and grisorixin methyl ester from the Algerian soil - living Streptomyces youssoufiensis SF10 strain: a computational study
on their epimeric structures and evaluation of
glioblastoma stem
cells growth inhibition — Nassima Leulmi — Natural Product Research