Sentences with phrase «on hematopoietic»

Kronenwett et al. «Oligodeoxyribonucleotide Uptake in Primary Human Hematopoietic Cells Is Enhanced by Cationic Lipids and Depends on the Hematopoietic Cell Subset», Blood, 91 (3): 852 - 862, 1998.

He has been interested in differentiation and growth control throughout his career and is an expert on hematopoietic stem cells, macrophage differentiation, hematopoietic and Maf family transcription factors.

(For information on hematopoietic stem cells, see the All Things Stem Cell article «Hematopoietic Stem Cells: A Long History in Brief»).

We examine their original thymic development: selection on hematopoietic cells leading to the acquisition of an original differentiation program.

Early discoveries led researchers to home in on the hematopoietic system, the organs that produce the two kinds of blood cells, lymphoid and myeloid cells.

Not exact matches

I spent the next decade completing rigorous basic science research training: completing a high school summer internship, attending the University of Maryland, Baltimore County as a Meyerhoff Scholar, and completing my Ph.D. in the Stanford immunology program, where my work focused on the mechanisms regulating hematopoietic and leukemic stem cells.

When Busch turned on the marker in adult animals, it became visible that at least one third (approximately 5000 cells) of a mouse's hematopoietic stem cells produce differentiated progenitor cells.

«Proper blood cell production is dependent on functioning hematopoietic stem and progenitor cells that are destroyed during conditioning procedures for transplantation or following bone marrow injury,» said the study's first author Kevin A. Goncalves, who performed this research as part of his PhD studies in cellular and molecular physiology at the Sackler School.

To gauge the effect off the loss of imprinting control on the maintenance of the quiescent hematopoietic stem cell pool, Venkatraman analyzed the numbers of quiescent, active and differentiated hematopoietic stem cells in mouse bone marrow.

Earlier mouse studies by Li and his collaborators had indicated that the expression of several imprinted genes changes as hematopoietic stem cells embark on their journey from quiescent reserve cells to multi-lineage progenitor cells, which form the many highly specialized cell types that circulate within the blood stream.

«By being able to distinguish benign from malignant aging based on distinctive RNA splicing patterns, we can develop therapeutic strategies that selectively target leukemia stem cells while sparing normal hematopoietic stem cells,» she said.

Basic research has centered on identifying and characterizing hematopoietic stem cells, however, it is still not clear how hematopoietic stem cells actually work, and how they are regulated because of the complexity of the bone marrow microenvironment.

Before September, researchers had pinned their hopes on adult hematopoietic stem cells — blood - producing stem cells.

Beilhack and colleagues found that a slightly modified version of STAR2 has a similar effect on human T reg cells, suggesting that the approach could also prevent GvHD in leukemia and lymphoma patients after bone marrow or hematopoietic stem cell transplants.

The meeting focuses on basic and translational research and offers a unique occasion to exchange ideas on genetics of hematological malignancies, hematopoietic stem cells, genome editing and immunotherapy.

The researchers focused on how hematopoietic stem cells developed into one of two types of white blood cells: macrophages or neutrophils.

Research Focus: Dr. Signer is a stem cell biologist whose trailblazing work on protein synthesis in hematopoietic stem cells opened the door to unchartered areas of cellular investigation.

There are no specific markers to identify them; however, they are negative for hematopoietic cell markers like CD34 / 45 / HLA - DR and express CD90 / 73/105 on their surface 2, 3, 4.

Discussion themes included: - stem cell heterogeneity - stem cell fate decisions - stem cells in regeneration & development - stem cells in disease & treatment - stem cell related bioengineering & biomaterial - theoretical stem cell biology - mathematical modelling with a focus (but no restriction) on neural stem cells, hematopoietic stem cells and diabetes.

In that program, we focused on treating children with both malignant and genetic conditions with generally allogeneic hematopoietic stem cell transplantation.

The chemokine receptor CXCR - 4 is expressed on CD34 + hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell - derived factor - 1.

«On the symmetry of siblings: automated single - cell tracking to quantify the behavior of hematopoietic stem cells in a biomimetic setup» is featured on the February issue coveOn the symmetry of siblings: automated single - cell tracking to quantify the behavior of hematopoietic stem cells in a biomimetic setup» is featured on the February issue coveon the February issue cover.

Scherf N, Franke K, Glauche I, Kurth I, Bornhäuser M, Werner C, Pompe T, Roeder I On the symmetry of siblings: automated single - cell tracking to quantify the behavior of hematopoietic stem cells in a biomimetic setup.

Title: Hematopoietic Stem Cell Function and Survival Depend on c - Myc and N - Myc Activity Authors: Laurenti E, Varnum - Finney B, Wilson A, Ferrero I, Blanco - Bose WE, Ehninger A, Knoepfler PS, Cheng PF, MacDonald HR, Eisenman RN, Bernstein ID, Trumpp A Date: 2008 Publication Details: Cell Stem Cell, Volume 3, Issue 6, 611 - 624, 4 December 2008

Title: On the symmetry of siblings: automated single - cell tracking to quantify the behavior of hematopoietic stem cells in a biomimetic setup Authors: Scherf N, Franke K, Glauche I, Kurth I, Bornhauser M, Werner C, Pompe T, Roeder I Date: 2012 Publication Details: Exp Hematol.

For more information, check out our recent webinar with Dr. Suzan Imren on her work with Drs. Colleen Delaney and Guy Sauvageau on ex vivo culture and expansion of normal and leukemic hematopoietic cells.

Clinical experiences for the nurse practitioner fellow include rotations on the leukemia, lymphoma, solid tumor, neuro - oncology, late effects, hematology, the inpatient general hematology / oncology unit, hematopoietic stem cell transplant unit, and palliative care.

Professor Kyurkchiev's group is currently developing a project on the controlled differentiation of human induced pluripotent stem cells into hematopoietic stem cells and lymphoid cells.

The lab will be focused on the identification of cellular and molecular events regulating hematopoietic cell fate decisions with emphasis on DC development.

We discovered that CD45 does not colocalize with lipid rafts on murine and human non-transformed hematopoietic cells.

It is well known that HDAC inhibitors are potent anticancer drugs in hematopoietic malignancies, including lymphoma.19 — 21 The aim of using HDAC inhibitors is to restore normal histone modification patterns through inhibition of various components of the epigenetic machinery.22, 23 In B - cell lymphoma, HDAC inhibitors can rescue deficits in histone acetylation induced by EP300 / CREBBP mutations, 24 rendering tumor cells more sensitive to suberoylanilide hydroxamic acid.25 This can explain why chidamide also has favorable efficacy on PTCL - NOS patients bearing EP300 / CREBBP mutations.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

Dr. Péault is internationally recognized principally for his work on the prospective identification and characterization of human hematopoietic (blood) stem cells, of which his laboratory has also deciphered the ultimate origin during embryonic life.

Interestingly, Patel et al. discovered that while cosmic radiation represents a significant risk to the hematopoietic system, there is no dependence on MMR capacity.

Shier LR, Schultz KR, Imren S, Regan J, Issekutz A, Sadek I, Gilman A, Panzarella T, Eaves CJ, Couban S. Differential Effects of G - CSF on Marrow and Blood - Derived Hematopoietic and Immune Cell Populations in Healthy Human Donors.

Further, it has remained a challenge to obtain enough hematopoietic cells for studies on in vitro long - term engraftment.

The increase in expression of donor type MHC antigens on the HPC - derived hematopoietic cells was gradual.

On long - term monitoring, HPC - derived hematopoietic cells remained detectable in both the allogenic and syngeneic mice, albeit declining with time.

TNFR1 is expressed on most cell types, while TNFR2 expression is restricted to endothelial, hematopoietic and some neuronal populations [37], [38].

Dr. Gazit is focusing on how to develop targeted treatment of cancer cells using hematopoietic stem cells — stem cells used in cancer treatment because of their ability to divide and form new and different kinds of blood cells.

Because Syk is expressed in many kinds of hematopoietic lineage cells and involved in various ITAM - mediated signal transduction pathways (45), our current finding that RhoH facilitates Syk activation will shed new light on ITAM - based immune responses.

The Workshop on Inherited Hematopoietic Malignancies will discuss the scientific advances in understanding the pathogenesis of cancer development in individuals and families with germline mutations and predisposition to bone marrow derived malignancies.

Laboratory model of immune system overcomes ethical constraints on studies of hematopoietic stem cells in humans.

The workshop will focus on topics such as; hematopoietic stem cell biology, leukemogenesis, cell signaling, transcription factors, epigenetic effects, and other topics related to myeloid biology.

Myelosuppression is a well - established side effect of current AML therapies, with prolonged events leading to an increased risk of infections and death.44 Consequently, therapies that preferentially kill leukemic cells over normal bone marrow cells are urgently required, and the overexpression of CD123 on AML leukemic stem cells and blasts compared with normal hematopoietic cells contributes to its attractiveness as a therapeutic target in this disease.6, 45 However, severe myelosuppression and myeloablation have emerged for some investigational CD123 - targeted treatment modalities.

New Insights on Pain and Opioid Use in People With Sickle Cell Disease After Hematopoietic Stem Cell Transplant (March 12, 2018)

Furthermore, there is evidence suggesting an association of replication stress on rDNA loci with the aging of hematopoietic stem cells, adding more evidence to the general function of the nucleolus in genome integrity and aging.