Sentences with phrase «on human cells called»

The Discher Lab has since shown that a protein on human cells called CD47 functions as a «marker of self» by interacting with a protein on the surface of macrophages called SIRPA.

Not exact matches

Hoping to learn something about how the human body defends itself against cancer, he had zeroed in on a complex regiment of lymphocytes called T cells, common to the immune systems in both mouse and man.

This study built on previous research from the Sundrud lab, which showed that when TH17 cells entered the intestine in human tissue samples, they increased the expression of a gene called MDR1.

These «organs on a chip,» as they are called, are typically glass slides coated with human cells that have been configured to mimic a particular tissue or interface between tissues.

Oliver Brüstle, director of the Institute of Reconstructive Neurobiology at the University of Bonn, Germany, who had a patent on a method for generating neurons from human embryonic stem cells rejected by the court, called the ruling «the worst possible outcome», and «a disaster for Europe».

A research team led by scientists from Brigham and Women's Hospital has developed a novel technology platform that enables the continuous and automated monitoring of so - called «organs - on - chips» — tiny devices that incorporate living cells to mimic the biology of bona fide human organs.

By now, European astronauts had hoped to be established in their space laboratory called Columbus, where they would be melting and solidifying conductive metals, studying microgravity effects on single - celled organisms, investigating human balance disorders, and carrying out dozens of other experiments.

In a double - barreled discovery, Brady and co-investigator Louis Cohen found that gut bacteria and human cells, though different in many ways, speak what is basically the same chemical language, based on molecules called ligands.

MERS CoV (CoV stands for coronavirus) has on its surface an array of spike - shaped proteins that bind to host cells — specifically to receptor proteins called DPP4 on the surface of cells that line human airways.

In March the Field Museum opened a controversial new exhibit called the Evolving Planet, which takes visitors on a 4 - billion - year journey that shows life on Earth developing from single - celled organisms to dinosaurs and finally to humans.

A new study, however, provides insights on the cellular mechanisms that might be targeted to help certain stem cells - called human mesenchymal stem cells (hMSCs)- maintain properties needed to make them clinically useful.

PARIS — As scientists race to finish a rough draft of the human genome, a European consortium is about to launch an effort to pinpoint every key spot in our genetic code where cells turn genes on and off by adding a molecule called a methyl group.

All human cells contain a protein called CD47 on their outer membrane coat.

The new technique — called DNA Programmed Assembly of Cells (DPAC) and reported in the journal Nature Methods on August 31, 2015 — allows researchers to create arrays of thousands of custom - designed organoids, such as models of human mammary glands containing several hundred cells each, which can be built in a matter of hCells (DPAC) and reported in the journal Nature Methods on August 31, 2015 — allows researchers to create arrays of thousands of custom - designed organoids, such as models of human mammary glands containing several hundred cells each, which can be built in a matter of hcells each, which can be built in a matter of hours.

Amid rumors that precision gene - editing techniques have been used to modify the DNA of human embryos, researchers have called for a moratorium on the use of the technology in reproductive cells.

We already knew that E. coli can grip to human cells using hair - like appendages that have tiny protein hooks on their tips, but until now no one had worked out the structure of this protein, called FimH, or how it interacts with human cells.

The approach developed by the MGH team focuses on small areas of the human genome — so - called polyguanine (poly - G) repeats that are particularly susceptible to mutation, with genetic «mistakes» occurring frequently during cell division.

That report — a world first — fuelled global deliberations over the ethics of modifying embryos and human reproductive cells, and led to calls for a moratorium on even such proof - of - principle research.

The researchers modified a type of human immune cell — called T lymphocytes, or T cells — to target a molecule called CS1, which is found on more than 95 percent of myeloma cells, and to kill the cells.

U.S. Supreme Court rejects petition calling for ban on taxpayer - funded human embryonic stem cell research

Researchers at the Fund for the Replacement of Animals in Medical Experiments (FRAME) in Nottingham, have just finished the first stage of development, which draws on research showing that human skin cells produce chemicals called cytokines when exposed to chemicals that are irritants.

In one well - studied example, the bacteria called Campylobacter jejuni, a common cause of food poisoning, carries a lipid molecule on its outer coat that resembles so - called gangliosides, molecules that help human nerve cells recognize and communicate with each other.

The protein LecA on the surface of the bacteria binds to sugar on special lipid molecules, so - called Gb3 lipids, which are present in the outer membrane of human cells.

«This is important,» says Ponichtera, «because CD209a is a mouse equivalent of a molecule that in humans is called DC - SIGN, a lectin receptor on dendritic cells that senses a variety of pathogens, including the virus that causes AIDS.

In their new paper in Journal of Immunology, Mandy Ford, Craig Coopersmith and colleagues show that 2B4 levels are increased on certain types of T cells (CD4 + memory cells) in human sepsis patients and in a mouse model of sepsis called CLP (cecal ligation + puncture).

February 2010 - Italian stem cell scientists challenge goverment EuroSyStem scientist Elena Cattaneo challenges Italian government - the story continues In the summer of 2009, three Italian stem celli scientists unsuccessfully challenged their government in the courts over its decision to exclude human embryonic stem cell research from a ministerial funding call for projects on stem cell biology.

Peter and colleagues focused their initial studies on a standard panel, known as NCI60, of 60 human tumor cell lines that can genetically be divided into two large groups, which they called superclusters 1 and 2.

However, when the 8 - million - Euro funding call was made public, a sentence had been introduced that explicitly excluded research on human embryonic stem cells.

The finding, the first discovery of a so - called «master» gene for myocardial, or heart muscle, cells in an animal model, puts researchers on track for exploring the capability of homologous genes in mice and humans.

In recent years, researchers have developed so - called «senolytic» drugs that wipe out senescent cells in aging mice and mouse models of age - related disease, exploiting the high dependence of these cells on specific biochemical survival pathways.9, 10 In these studies, senolytic drugs have restored exercise capacity9 and formation of new blood and immune precursor cells11 in aging mice to near youthful norms, and prevented or treated mouse models of diseases of aging like osteoarthritis, 12 fibrotic lung disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with human clinical trials expected to begin in 2019.

In an attempt to solve these issues and to follow up on the «Call for Standardized Naming and Reporting of Human ESC and iPSC Lines» (1), a tool was created to use identifying information to generate a unique cell line name.

In a study published Thursday in the journal Cell, the researchers shed light on the evolutionary history of these pathogens, which are fast developing resistance to even the so - called last - resort antibiotics, due to their high consumption among humans.

The Swedish part of the effort, called the Human Developmental Cell Atlas (HDCA) program, includes researchers from Karolinska Institutet, Stockholm University and KTH, focusing on brain, lung, heart and fetal development during the first 12 -LSB-...]

Once taken up by antigen - presenting cells, which help focus the immune system on an invader, the vaccine releases a factor that heightens their attention specifically to the cancer - promoting protein E7, a so - called oncoprotein that not only enables the human papillomavirus to multiply, but potentially cervical cancer cells to do the same.

Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters

«Among other things, the NAS Report calls for the Environmental Protection Agency to implement a toxicity testing strategy that is based on non-mammalian systems and human cells in culture [in vitro],» Rene explains.

This solo exhibition displays cell - like imagery and microbiology - inspired pieces to create a call for awareness about the control human beings have over the eco-system, on view through November 25.