Sentences with phrase «on human cells which»

Not exact matches

On the logistics end, it is easier to manufacture certain stem - cell therapies, which will be key for human trials like the heart - muscle - regeneration program.

Organovo, a start - up in Los Angeles, is working on a process in which a bioprinter will squirt multiple layers of human tissue cells onto special paper.

ReInnervate, a start - up in Durham, England, is developing a tiny, three - dimensional plastic scaffolding on which human cells can be grown into artificial tissue, and perhaps eventually into replacements for organs.

Research on a new «gene editing» technology known as CRISPR — which theoretically allows any cell or organism to have its genome altered — is advancing exponentially, with early research ongoing on human embryos created for that purpose.

The human body has about 1,000 kinds of such receptors, structures on the surface of cells, which let the body respond to a wide variety of chemical signals, like adrenaline.

No doubt it is true, scientifically speaking, that no distinct center of superhuman consciousness has yet appeared on earth (at least in the living world) for which it may be claimed or predicted that one day it will exercise a centralizing function, in relation to associated human thought, similar to the role of the individual «I» in relation to the cells of the brain.

Unfortunately, at this formative stage in their lives one viewpoint is pushed to the fore on campus, and that's the opinion that euthanasia, abortion, embryonic stem cell research and a host of other practices which strip humans of their most fundamental right are good things.

There have been lots of cell and animal research, which prove that turmeric has a good influence on a number of illnesses and also several human studies have shown positive results as well.

«There are perfectly ethical ways of obtaining stem cells to cure disease, which do not involve embryo destruction, so no matter what moral value one places on the human embryo, we do not need to use it.»

This study built on previous research from the Sundrud lab, which showed that when TH17 cells entered the intestine in human tissue samples, they increased the expression of a gene called MDR1.

To create the effect of tobacco smoke on cells, Vaz, Baylin and their colleagues began their studies with human bronchial cells, which line the airways of the lungs, and grew them in a laboratory.

Scientists are forced either to experiment on whole animals, which is expensive, raises ethical issues and may not predict effects in humans, or to perform tests on microscopic human cells found in tissue cultures, which have been altered to live forever and bear little relation to actual living, breathing people.

Endocytosis of Frizzled 4 (Fz4) in human embryonic kidney 293 cells was dependent on added Wnt5A protein and was accomplished by the multifunctional adaptor protein β - arrestin 2 (βarr2), which was recruited to Fz4 by binding to phosphorylated Dvl2.

With respect to the latter, it states, «no one shall be under a duty to participate in any manner of research on human stem cells to which he has a conscientious objection.»

Lab testing showed that the plant - made virus particles, which naturally bind to receptors on cancer cells, were taken in by human breast cancer cells.

In experiments conducted on human lung endothelial cells and in mice, the researchers showed that NS1 caused permeability of the endothelium, which lines the walls of blood and lymph vessels.

By analyzing chemical changes of the IRS - 2 protein in immortalized cultures of human white blood cells, it determined that IRS - 2 appeared in two different forms — «on,» which allows the signal to pass through, and «off,» which stops the signal from activating the cells into M2 macrophages.

The researchers observed the effect of the synthetically produced molecule, JK - 31, on the growth and proliferation of a model human breast cancer cell line and found that it effectively blocked the protein cyclin - dependent kinase 1 (CDK1), which plays a key part in the process of the division of cancer cells, and therefore inhibited the proliferation of the cells.

The process, reported in Human Reproduction, utilizes DNA fingerprinting (an assessment of active genes in a given cell) to boost the success rate of IVF and lower the chances of risky multiple births by identifying which of several five - day - old embryos are most likely to result in pregnancy The new method, which will replace unproved alternatives such as choosing embryos based on their shape, is likely to up the success of women becoming pregnant and lower their chances of having multiple births.

This is in stark contrast to much previous work, which has focused on human embryonic stem cells, or hESCs.

In the past year, the South Korean Food and Drug Administration (FDA) has approved the world's first three stem - cell treatments — Hearticellgram - AMI, Cupistem and Cartistem — which followed on the heels of clinical tests for human embryonic stem - cell therapies approved in 2010, according to the health ministry.

Building on the newly - published pilot study, the team will conduct experiments using a windtunnel which measures the behaviour of mosquitoes towards odours and electrodes which track the response of individual odour - detecting cells from within the antenna of the mosquito in specially - designed secure laboratories at the School to measure the responses of malaria - infected Anopheles gambiae s.s. females to human odours.

To see whether cancer stem cell renewal involves a chain of events similar to that used by embryonic stem cells, and whether the process was affected by oxygen levels, Semenza and graduate student Chuanzhao Zhang focused their studies on two human breast cancer cell lines that responded to low oxygen by ramping up production of the protein ALKBH5, which removes methyl groups from mRNAs.

The image shows human cells (green) on the nanoneedles (orange), which has DNA injected into the cells» nuclei (Blue).

The final guidelines on research with human embryonic stem cells issued on Monday by the National Institutes of Health set out criteria for determining which ES cell lines can be used in federally funded experiments and give NIH discretion to approve old lines that don't meet stringent modern ethical requirements.

The authors believe theirs is among the first human studies to investigate the influence of phthalate exposure on sperm epigenetics, embryo development and whether DNA methylation in sperm cells may be a path by which a father's environmental exposure influences these endpoints.

Wild H5N1 viruses can not latch on tothe cells in a person's nose and throat, but the mutant strains created by Fouchier and Kawaoka can spread between ferrets, which are viewed as a good animal model of flu transmission between humans.

In March the Field Museum opened a controversial new exhibit called the Evolving Planet, which takes visitors on a 4 - billion - year journey that shows life on Earth developing from single - celled organisms to dinosaurs and finally to humans.

The new technique — called DNA Programmed Assembly of Cells (DPAC) and reported in the journal Nature Methods on August 31, 2015 — allows researchers to create arrays of thousands of custom - designed organoids, such as models of human mammary glands containing several hundred cells each, which can be built in a matter of hCells (DPAC) and reported in the journal Nature Methods on August 31, 2015 — allows researchers to create arrays of thousands of custom - designed organoids, such as models of human mammary glands containing several hundred cells each, which can be built in a matter of hcells each, which can be built in a matter of hours.

«With the help of animal biologists, we found that chem7 had no effect on budding yeasts and human cells, which indicates that chem7 does not inhibit the cell division of animal cells.»

In the second study in Science, researchers from Harvard University in Boston, Massachusetts, created a chip 1 to 2 centimeters long in which a 1 millimeter - wide channel, coated with human lung cells on the inside and overlaid with human blood capillaries on the outside, mimicked the air sacs, or alveoli, of the lungs.

Yet 30 % of American voters describe themselves as evangelicals, and the voices of this massive segment deserve to be heard, according to panel speaker James Childress, formerly of President Bill Clinton's National Bioethics Advisory Commission, which informed the president on stem cell research, cloning, and human subjects research.

The researchers focused on one common epigenetic process known as methylation, in which methyl (CH3) groups attach in various patterns to the genes of human cells.

- Our results provide new insights into the mechanisms of how POLR3G gene regulates stem cell state, which in turn sheds light on the complex mechanisms with which human embryonic stem cells both self - renew and maintain the ability to differentiate.

Malinski's team has developed unique methods and systems of measurements using nanosensors, which are about 1,000 times smaller in diameter than a human hair, to track the impacts of Vitamin D3 on single endothelial cells, a vital regulatory component of the cardiovascular system.

The group focused its efforts on human pluripotent stem cells, which can become all of the body's tissues.

The epithelium's maturation into a villus intestinal epithelium with long finger - like extensions was helped along by co-culturing human intestinal microvascular endothelial cells on the opposite side of the shared matrix - coated porous membrane in the «vascular» channel where they assembled a surrogate blood vessel with a hollow lumen through which feeding medium was flowed.

In an effort to overcome these limitations, a team at the Wyss Institute for Biologically Inspired Engineering led by its Founding Director, Donald Ingber, M.D., Ph.D., had previously engineered a microfluidic «Organ - on - a-Chip» (Organ Chip) culture device in which cells from a human intestinal cell line originally isolated from a tumor were cultured in one of two parallel running channels, separated by a porous matrix - coated membrane from human blood vessel - derived endothelial cells in the adjacent channel.

Although this human Gut Chip recreated the villus epithelium of normal intestine and enabled new insights into how flow and cyclic peristalsis affects intestinal differentiation and function, it could not be used to study processes that relied on normal intestinal cells from individual donors, which, for example, is crucial for studying patient - specific responses for personalized medicine.

MCC is associated with a virus, the Merkel cell polyomavirus, which is quite common, often found on normal human skin and surfaces that are frequently touched, Dr. Nghiem says.

The researchers modified a type of human immune cell — called T lymphocytes, or T cells — to target a molecule called CS1, which is found on more than 95 percent of myeloma cells, and to kill the cells.

Researchers at the Fund for the Replacement of Animals in Medical Experiments (FRAME) in Nottingham, have just finished the first stage of development, which draws on research showing that human skin cells produce chemicals called cytokines when exposed to chemicals that are irritants.

To study this barrier and determine why a lack of blood flow causes it to leak, the researchers built a blood - vessel - on - a-chip model consisting of a channel lined with a layer of human endothelial cells surrounded by extracellular matrix within a microfluidic device, which allowed them to easily simulate and control the flow of blood through a vessel and evaluate the cells» responses.

The study, which is published in the journal Nature Communications, was conducted on human tumour cells and on mice, and offers hope of a much improved therapy for a severe form of cancer.

This study, which will be published Oct. 24 in eLife, and two other new Northwestern studies in Oncotarget and Cell Cycle by the Peter group, describe the discovery of the assassin molecules present in multiple human genes and their powerful effect on cancer in mice.

Dr. Hashino said these findings are «a real game changer, because up until now, potential drugs or therapies have been tested on animal cells, which often behave differently from human cells.»

«The resulting hydrogel composed of physically self - assembled CarHC polymers exhibited a rapid gel - sol transition on light exposure, which enabled the facile release / recovery of 3T3 fibroblasts and human mesenchymal stem cells (hMSCs) from 3D cultures while maintaining their viability.»

By analyzing a dataset of human immune cells stimulated with interferon — a signaling protein created in response to pathogens or tumor cells — the team could precisely identify which genes were switched on in each of 13 responding cell types.

The protein LecA on the surface of the bacteria binds to sugar on special lipid molecules, so - called Gb3 lipids, which are present in the outer membrane of human cells.

Importantly, intraperitoneal inoculation of pancreatic homogenates containing IAPP aggregates into transgenic mice expressing human IAPP dramatically accelerates IAPP amyloid deposition, which was accompanied by clinical abnormalities typical of T2D, including hyperglycemia, impaired glucose tolerance, and a substantial reduction on β cell number and mass.