1:45 PM An evolutionary perspective
on human germline mutation.
Parental influence
on human germline de novo mutations in 1,548 trios from Iceland Jonsson H et al Nature 2017 Sept 20.
So far, the U.S. government hasn't funded research
on human germline modification, and other governments have banned it, so we'll talk about somatic cells [sources: Baruch, Hanna].
His other recent books include «Transhumanism and Transcendence: Christian Hope in an Age of Technological Transcendence» and «Design and Destiny: Jewish and Christian Perspectives
on Human Germline Modification.»
The Forum
on Human Germline Interventions, organized by AAAS, convened a multi-disciplinary group of scientists, ethicists, and theologians to participate in discussions regarding scientific freedom and responsibility issues; the history and status of religious involvement; ethical and theological issues; therapeutic vs. enhancement applications; and setting policy and developing guidelines
on human germline research and applications.
Not exact matches
Over eons, pieces of mitochondrial DNA have naturally inserted into eukaryotic genomes; at birth, for example,
humans have between 755 and 1,155
germline mitochondrial DNA inserts that have been passed
on through generations.
In October, a UNESCO bioethics panel recommended a temporary ban
on «engineering of the
human germline, at least as long as the safety and efficacy of the procedures are not adequately proven».
Scientists and the public are now considering the ethics of a tool that might be used someday to edit the genes in the
human germline (eggs and sperm) to create new characteristics that could be passed
on to subsequent generations, or to correct diseased or otherwise «unwanted» genes.
An international group of 11 organizations with genetics expertise has issued a policy statement
on germline genome editing in
humans, which recommends against genome editing that culminates in
human pregnancy; supports publicly funded, in vitro research into its potential clinical applications; and outlines scientific and societal steps necessary before implementation of such clinical applications is considered.
But he thinks that US scientists will inevitably take
on such research, although federal funding of research
on human embryos and
germline modification is prohibited.
However, they remain supportive of basic CRISPR research
on animals and non-embryonic
human cells to see if
human germline gene therapy might be helpful in the future to fix genetic mutations.
Citation: Li C, Yu H, Ma Y, Shi G, Jiang J, Gu J, et al. (2009)
Germline - Competent Mouse - Induced Pluripotent Stem Cell Lines Generated
on Human Fibroblasts without Exogenous Leukemia Inhibitory Factor.
(2) Currently, there is no reason to prohibit in vitro
germline genome editing
on human embryos and gametes, with appropriate oversight and consent from donors, to facilitate research
on the possible future clinical applications of gene editing.