Sentences with phrase «on human lung»

Anyway, the study started in the University of Helsinki Veterinary Teaching Hospital and I'm glad someone is getting a new perspective on human lung problems.

STUDY TWO — next we have this study in which scientists analysed the effect of fluoride on human lung cells.

Title of thesis: «Study of the pro-apoptotic effect of histones deacetylases inhibitors, used alone and concurrently with chemotherapeutic agents, on human lung cancer cells».

«Study of the pro-apoptotic effect of molecules interfering with epigenetic mechanisms on human lung cancer cells».

Their findings, reported in Nature Communications, may shed light on human lung disease, in particular, the mechanism behind non-familial pulmonary hypertension in patients with conditions such as emphysema and pulmonary fibrosis.

In experiments conducted on human lung endothelial cells and in mice, the researchers showed that NS1 caused permeability of the endothelium, which lines the walls of blood and lymph vessels.

Not exact matches

Panoskaltsis - Mortari's team has been working on rebuilding lungs and other parts of the respiratory system using human stem cells.

By printing multiple lung airways — or any other afflicted organ — from a human patient and testing drugs on them, pharma companies can bypass the ethically challenged practice of testing on animals and proceed to human clinical trials with greater confidence the drugs will actually work, according to Wadsworth.

There has never been a randomized, prospective, controlled study in humans on cigarette smoking, but we have still been able to determine that it causes lung cancer.

She has got to have the best lungs of any human on the planet.

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To create the effect of tobacco smoke on cells, Vaz, Baylin and their colleagues began their studies with human bronchial cells, which line the airways of the lungs, and grew them in a laboratory.

Ultimately, the goal is to make chips that mimic more complex systems — perhaps even entire humans, says Donald Ingber, director of Harvard's Wyss Institute for Biologically Inspired Engineering and co-creator of the lung - on - a-chip.

The lung - on - a-chip was the first human organ to be scaled down to chip form.

Scientists have long experimented with organs - on - chips: tiny representations of human organs, such as lungs, hearts and intestines, made from cells embedded on plastic about the size of a computer memory stick.

Potti and his colleagues began by testing chemotherapy drugs on cultured cell lines from human tumors, such as from the lung, breast, or ovary.

Last June Ingber's team reported that it had placed human lung lining cells and human capillary cells on either side of a porous, flexible polymer membrane.

First, the destabilizing effects of VX - 770 on the corrected CFTR protein might be less robust in the human body than were the effects seen in lab tests using human lung cells.

One postdoc presents data on her efforts to develop an organoid model for small - cell lung cancer; another reports progress on culturing hormone - secreting organoids from human gut tissue.

In the second study in Science, researchers from Harvard University in Boston, Massachusetts, created a chip 1 to 2 centimeters long in which a 1 millimeter - wide channel, coated with human lung cells on the inside and overlaid with human blood capillaries on the outside, mimicked the air sacs, or alveoli, of the lungs.

A key experiment, he says, will be to find where the new virus latches on to the human lung.

When growing on surfaces (including human skin, lung, heart, or bladder) many bacteria form so - called biofilms that consist of structured communities of identical bacteria.

«The introduction of mitochondria into damaged cells has beneficial effects on the health of cells and, in the long term, we believe that mesenchymal stem cells could even be engineered to create more effective therapies for lung disease in humans.»

The consensus on human - caused climate change is among the strongest observed in the sciences — about as strong as the consensus surrounding the link between smoking and lung cancer.

Our investigations on human cell lines in the laboratory have shown that synthetic cannabinoids, in the high concentrations found in cells in the oral cavity or in the lungs, for example, are likely to trigger damage to the DNA that may have significant consequences for the consumers of such substances.

Clinical applications Part of the reason dolphins are expert divers is because they can collapse their alveoli, the little sacks on the lungs that monitor air flow, and then open them up again, «but humans can't do that,» Fahlman said.

«The development of this microfluidic lung model, as well as other organs - on - chip, holds the promise of improving the physiological relevance of cellular models for more accurate prediction of the effects of toxicants and drugs on humans, and for reducing the use of animals in medical and pharmaceutical research,» said Sonia Grego, Ph.D., research scientist at RTI and the project's principal investigator.

Funding: NIH's National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Heart, Lung, and Blood Institute (NHLBI), National Institute on Aging (NIA), National Center for Advancing Translational Sciences (NCATS), National Cancer Institute (NCI), and National Human Genome Research Institute (NHGRI); and many other funding entities (see reference paper for the full list).

The 19 NIH institutes, centers and offices contributing to the Knockout Mouse Project are: the NIH Office of Strategic Coordination / Common Fund; NCRR; the National Eye Institute; NHGRI; the National Institute of Allergy and Infectious Diseases; the National Heart, Lung and Blood Institute; the National Institute on Aging; the National Institute of Alcohol Abuse and Alcoholism; the National Institute of Arthritis and Musculoskeletal and Skin Diseases; the Eunice Kennedy Shriver National Institute of Child Health and Human Development; NIDCD; the National Institute of Dental and Craniofacial Research; the National Institute of Environmental Health Sciences; the National Institute of General Medical Sciences; the National Institute of Mental Health; the National Institute of Neurological Disorders and Stroke; the National Institute of Diabetes and Digestive and Kidney Diseases; the National Cancer Institute; and the Office of AIDS Research.

The 19 NIH institutes, centers and offices contributing to the contracts are: National Center for Complementary and Alternative Medicine, National Center for Research Resources, National Eye Institute, National Human Genome Research Institute, National Heart, Lung and Blood Institute, National Institute on Aging, National Institute of Alcohol Abuse and Alcoholism, National Institute of Allergy and Infectious Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Child Health and Human Development, National Institute on Deafness and Other Communication Disorders, National Institute of Dental and Craniofacial Research, National Institute on Drug Abuse, National Institute of Environmental Health Sciences, National Institute of General Medical Sciences, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Institute of Nursing Research, and the Office of AIDS Research.

Inclusion Criteria: • Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 • Have histologically or cytologically confirmed advanced or metastatic non-small cell lung cancer (NSCLC)(Stage IIIb or greater) • Measurable disease, as defined by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 • Known PD - L1 tumor status as determined by an immunohistochemistry (IHC) assay performed by the central laboratory on tissue obtained at Screening • A woman of childbearing potential must have a negative highly sensitive serum (beta - human chorionic gonadotropin [beta - hCG]-RRB- at Screening within 14 days prior to study drug administration Inclusion Criteria for Crossover: • Participants must have been randomized to Arm A of the study and had radiographic disease progression according to RECIST 1.1 • Participants must have a mandatory biopsy at the time of disease progression according to RECIST 1.1 prior to crossing over.

Organ - on - a-chip technology may in part overcome this limitation, as exemplified by the «breathing» lung - on - a-chip that recapitulates the alveolar - capillary interface by co-culturing human alveolar epithelial cells and capillary endothelial cells on opposite sides of a flexible, porous, ECM - coated membrane.

Developing the lung - on - a-chip took nearly four years, but it took less than two to modify it to demonstrate a human disease.

To assess the expression of Tie2 and other Ang / Tie signalling molecules on human pericytes, a microarray - based expression profiling of human brain pericytes (BP), placenta pericytes, pancreas pericytes (PA), lung pericytes (LP), muscle pericytes (MP) and human umbilical vein endothelial cells (HUVEC) was performed.

Recent work from Fousteri Lab revealed a novel metabolic function of active transcription that is rapidly switched on globally in human cells to promote genetic accuracy, and reduce the mutation burden in genotoxins - exposed tissues, such as skin and lung, thus actively participating in lowering oncogenesis.

Building on that project, the researchers have now designed a machine that smokes cigarettes in a very human - like manner, and hooked it up to organs - on - chips lined by human lung small airway cells so the smoke interacts with these cells in a realistic way.

In recent years, researchers have developed so - called «senolytic» drugs that wipe out senescent cells in aging mice and mouse models of age - related disease, exploiting the high dependence of these cells on specific biochemical survival pathways.9, 10 In these studies, senolytic drugs have restored exercise capacity9 and formation of new blood and immune precursor cells11 in aging mice to near youthful norms, and prevented or treated mouse models of diseases of aging like osteoarthritis, 12 fibrotic lung disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with human clinical trials expected to begin in 2019.

Now a team at Harvard has designed a device that smokes cigarettes and sends the smoke through a human lung small airway - on - a-chip to examine just how the habit damages health.

Dumeetha Luthra is amazed by the team's cellular reconstruction of a human lung on a microchip.

Miller said that the viral receptor gene, HYAL2, was located on a region of human chromosome 3 that is frequently altered in lung cancers.

A study from Dr. Dusty Miller's laboratory indicates that Jaagsiekte sheep retrovirus (JSRV) infects both sheep and human cells cultured outside the body and does so by attaching to a receptor on the surface of lung cells.

The Swedish part of the effort, called the Human Developmental Cell Atlas (HDCA) program, includes researchers from Karolinska Institutet, Stockholm University and KTH, focusing on brain, lung, heart and fetal development during the first 12 -LSB-...]

The meeting will also feature other aspects of the Human Cell Atlas initiative, including updates on progress so far towards atlases of tumour, lung, gut, kidney and immune system cells.

After mroe than two years of testing on humans, the U.S. FDA has approved a new lung cancer pill for AstraZeneca, a British drugmaker.

The result was a highly selective drug they named SBI - 0206965, which successfully killed a number of cancer cell types, including human and mouse lung cancer cells and human brain cancer cells, some of which were previously shown to be particularly reliant on cellular recycling.

More than half of people can not pinpoint the exact location of the human heart on a diagram, and nearly 70 % can't correctly identify the shape of the lungs, according to the survey.

The effect of diet on the gluconeogenic capacity of rat - kidney - cortex slices [5] Liver and kidney metabolism during prolonged starvation [6] Unrecognized Pandemic «Subclinical» Diabetes of the Affluent Nations: Causes, Cost and Prevention [7] Carbohydrates and Immune Function [8] Overexpression of glut1 and glut3 in stage I nonsmall cell lung carcinoma is Associated with poor survival [9] The in?uence of diet on the mucin carbohydrates in the chick intestinal tract [10] Rat intestinal mucosal responses to a microbial flora and different diets [12] Chronic Ethanol Induced Impairment of Hepatic Glycosylation Machinery in Rat Is Independent of Dietary Carbohydrate [13] Glycosylation in Cellular Mechanisms of Health and Disease [14] Metabolic Aberrations Associated with Arginine Deficiency [15] Glycerol gluconeogenesis in fasting humans

But what is truly amazing about jaggery is that it has a cleansing effect on human organs, especially the lungs, digestive tracks and oesophagus channels.

Released in theatres on August 24,1966, «Fantastic Voyage» was not only a film of authentic wonder but a science fiction masterpiece with amazing special effects... the team enters the body of a man where they see first hand the oceans of life within the human body that contains the «corpuscles», «the heart», «the lungs» and other features of the human body through which the crew move through are exquisitely designed in great detail with artistic quality.

(2) Under the bed looks like the top of a coffin, but (3) There is weight, human weight on top that you can slip into and make heavier, and you listen to the heart beat while you watch it pump and hear the nostrils hiss when their lungs press air and envy even the shortest breath.