Sentences with phrase «on human melanoma»

A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma.

A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma.

Analysis of antigens recognized on human melanoma cells by A2 - restricted cytolytic T lymphocytes (CTL).

To test their hypothesis, the researchers carried out experiments on human melanoma cells, a line of cancer cells they chose for their ability to grow easily and quickly.

Dr. Aplin and Jessica Teh, PhD, his senior postdoctoral researcher at Jefferson (Philadelphia University + Thomas Jefferson University), examined the effects of a combination of two FDA - approved targeted agents on human melanomas grafted onto mice.

(PMID: 7927540)[ii] Boël P, Wildmann C, Sensi M - L, Brasseur R, Renauld J - C, Coulie P, Boon T, van der Bruggen P. BAGE, a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes.

Not exact matches

In 2000, Medarex began its first phase of human testing on its new «CTLA -4-blockade» — in patients who had either prostate cancer or metastatic melanoma, a deadly form of skin cancer.

In one experiment this year, a team led by another CRISPR pioneer, Feng Zhang of the Broad Institute in Cambridge, Massachusetts, targeted the 20,000 or so known human genes, turning them on one by one in groups of cells to identify those involved in resistance to a melanoma drug.

One of these, UJ3, is as effective as the industry - standard drug Cisplatin in killing cancer cells in laboratory tests done on human esophageal cancer, breast cancer and melanoma.

«What's cool about this group of genes is that they also get turned on in human melanoma,» says Zon, who is also a member of the Harvard Stem Cell Institute and a Howard Hughes Medical Institute investigator.

The lesions and dark patches are a scalier version of what melanomas look like on humans, but it's unclear whether they make the animals unsafe to eat.

While past attempts to treat melanoma failed to meet expectations, an international team of researchers are hopeful that a compound they tested on both mice and on human cells in a petri dish takes a positive step toward creating a drug that can kill melanoma cancer cells without harming nearby healthy cells.

Gaugler B, Van den Eynde B, van der Bruggen P, Romero P, Gaforio JJ, De Plaen E, Lethé B, Brasseur F, Boon T. Human gene MAGE - 3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes.

Further research uncovered a broad spectrum of cell surface stem cell markers (e.g., CD133, CD44, and CD24) that allow the identification of CSCs in human solid tumors, including brain, breast, prostate, pancreas, liver, ovary, skin, colon cancers, and melanoma (3 - 6)(Figure 1 based on 7).

The terms «Malignant melanoma of skin» returned 0 free, full - text review articles on human participants.

Published in Human Molecular Genetics Ghiorzo P, Gargiulo S, Pastorino L, Nasti S, Cusano R, Bruno W, Gliori S, Sertoli MR, Burroni A, Savarino V, Gensini F, Sestini R, Queirolo P, Goldstein AM, Scarrà GB.Impact of E27X, a novel CDKN2A germ line mutation, on p16 and p14ARF expression in Italian melanoma families displaying pancreatic cancer and neuroblastoma Hum Mol Genet.

At the National Human Genome Research Institute, she's studying drug resistance in melanoma and in the lab performs Western blots on the gene products of SOX10 and PTEN.

They went on to show that Sox10, a factor needed for the formation of skin pigment cells from neural crest stem cells during development, was present at high levels in naevi and melanoma samples obtained from both the mouse model and human patients.

Knocking out or blocking the activity of Nrp1 on regulatory T cells in mouse models of several human cancers, including the deadly skin cancer melanoma, led to reduced, delayed or complete elimination of the tumors.

Surrey: These responses will (and should) be all about Domino, so let me give a quick shout - out to Peter, the wholesome normal human man who put on sunscreen before jumping out of a plane because he's more fearful of melanoma than Cable.

Next, doctors will try the same treatment on dogs with oral melanoma, a terrible disease similar to mucosal melanoma in humans.