Biology of Blood and Marrow Transplantation 20, no. 5 (2014): 640 - 645; De Lastours, V., et al. «Impact of fluoroquinolones
on human microbiota.
For example, many studies
on human microbiota identify species (or operational taxonomic units) and map evolutionary relationships using the 16S ribosomal RNA gene.
Not exact matches
Using a «gnotobiotic mouse model» — where mice were «colonized with a synthetic
human gut
microbiota composed of fully sequenced commensal bacteria» — Desai et al reported
on the effects of different diets with different fibre content.
The
human microbiome is the composite of genes of the microorganisms (
microbiota) living in and
on the
human body that influence the health and development of the host (1).
The researchers found that changes in the amount of protein and carbohydrates in the diet had a similar effect
on the
microbiota of dogs and
humans, independent of the dog's breed or sex.
Dr Luis Pedro Coelho, commented: «These findings suggest that dogs could be a better model for nutrition studies than pigs or mice and we could potentially use data from dogs to study the impact of diet
on gut
microbiota in
humans, and
humans could be a good model to study the nutrition of dogs.
The Wyss team believes the ability of the
human gut -
on - a-chip to culture the microbiome with
human gut cells also holds promise for the field of precision medicine, where a patient's own cells and gut
microbiota could one day be cultured inside a gut -
on - a-chip for testing different therapies and identifying an individualized treatment strategy.
«Healthy gut bacterial communities are known to benefit immune regulation, metabolism and potentially even the nervous system, so if cholera or other diarrheal diseases permanently impact the
microbiota, there could be long - term effects
on human health,» explains Regina LaRocque, MD, MPH, of the Massachusetts General Hospital (MGH) Division of Infectious Diseases, co-senior author of the paper.
Given that the investigators have previously shown the influence of the host molecular clock
on the gut
microbiota, they will also ask if taking this NSAID at different times of day might lead to higher efficacy and less side effects in animal models and eventually in
humans.
In order to find out which bacterial species may be present in the air and
on the surfaces inside spacecraft and how the composition of the
microbiota may change during
human habitation, a crew of six male «Marsonauts» lived inside a mock - up spacecraft, located in Moscow, from 3rd June 2010 to 5th November 2011.
Mammals —
humans included — depend
on their
microbiota, the collection of microorganisms they host in and
on their bodies.
Michael Fischbach (University of California, San Francisco)-- A chemical biologist, Dr. Fischbach's research is
on the
human microbiome (all of our microbes» genes), focusing
on the molecular mechanisms by which the
microbiota influence the host organism.
It has been proved that
microbiota has a strong impact
on development and
human health.
At Weizmann, she plans to investigate the impact of gut
microbiota on aging, and her goal is to improve
human health through personalized nutrition.
A few interesting articles in early life
human microbiome, plus: A comparison between Staphylococcus epidermidis commensal and pathogenic lineages from the skin of healthy individuals living in North American and India; A new tool to reconstruct microbial genome - scale metabolic models (GSMMs) from their genome sequence; The seasonal changes in Amazon rainforest soil microbiome are associated with changes in the canopy; A specific class of chemicals secreted by birds modulates their feather microbiome; chronic stress alters gut
microbiota and triggers a specific immune response in a mouse model of colitis; and evidence that the short chain fatty acids profile in the gut reflects the impact of dietary fibre
on the microbiome using the PolyFermS continuous intestinal fermentation model.
Plentiful opportunities for researchers to learn about and discuss important developments in the field of
human microbiota, the collection of microbes living in and
on our body that have a significant impact
on human health and well - being.
Influence of fecal collection conditions and 16S rRNA gene sequencing at two centers
on human gut
microbiota analysis — Jocelyn Sietsma Penington — Scientific Reports
The Gut Metagenome Changes in Parallel to Waist Circumference, Brain Iron Deposition and Cognitive Function JCEM June 7, 2017 Gerard Blasco, Jose Maria Moreno - Navarrete, Mireia Rivero, Vicente Perez - Brocal, Josep Garre - Olmo, Josep Puig, Pepus Daunis - i - Estadella, Carles Biarnes, Jordi Gich, Fernando Fernandez - Aranda, Angel Alberich - Bayarri, Andres Moya, Salvador Pedraza, Wifredo Ricart, Miguel Lopez, Manuel Portero - Otin, and Jose - Manuel Fernandez - Real
Microbiota perturbations seem to exert modulatory effects
on emotional behavior, stress - and pain - modulation systems in adult animals; however, limited information is available in
humans...
Humans rely
on their native
microbiota for nutrition and resistance to colonization by pathogens [3 — 6]; furthermore, recent discoveries have shown that symbiotic microbes make essential contributions to the development, metabolism, and immune response of the host [7 — 10].
Hence, a lot of necessary neurotransmitters in the body are generated by the gut
microbiota, exerting influence
on the
human body including the brain, among which many neurotransmitters in the
human gut
microbiota are also critical molecules.»
Long - term impacts of antibiotic exposure
on the
human intestinal
microbiota.
While not altering the overall structure of the
human colonic
microbiota, [rifaximin] increased bifidobacteria and led to variation of metabolic profiles associated with potential beneficial effects
on the host.
Nutrition - derived bioactive metabolites produced by gut
microbiota and their potential impact
on human health
The delicate balance between the
human microbiome and the development of psychopathologies is particularly interesting given the ease with which the microbiome can be altered by external factors, such as diet, 23 exposure to antimicrobials24, 25 or disrupted sleep patterns.26 For example, a link between antibiotic exposure and altered brain function is well evidenced by the psychiatric side - effects of antibiotics, which range from anxiety and panic to major depression, psychosis and delirium.1 A recent large population study reported that treatment with a single antibiotic course was associated with an increased risk for depression and anxiety, rising with multiple exposures.27 Bercik et al. 28 showed that oral administration of non-absorbable antimicrobials transiently altered the composition of the gut
microbiota in adult mice and increased exploratory behaviour and hippocampal expression of brain - derived neurotrophic factor (BDNF), while intraperitoneal administration had no effect
on behaviour.
Effects of a gluten - free diet
on gut
microbiota and immune function in healthy adult
human subjects.
The closest I've found to a
human clinical trial of beans
on intestinal permeability is this study, which found a Chinese medicinal gruel of Job's tears, oat, buckwheat, white bean, yellow corn, red bean, soybean, yam, big jujube, peanut, lotus seed, and wolfberry changed gut
microbiota, improved gut permeability, lowered endotoxemia, and improved inflammation markers.
Sources: Clemente, J.C., et al., «The Impact of the Gut
Microbiota on Human Health: An Integrative View,» Cell 2012; 148 (6): 1258 - 1270.
Dr. Justin Sonnenburg makes a powerful argument for viewing our
microbiota as the control center for
human biology — that our
microbiota are not just impacting digestion and absorption, but having systemic impacts
on our immune system, our metabolism,