They found similar effects using several different experimental approaches, including lab tests
on human tissue samples and animal studies.
The researchers haven't tested this method
on human tissue samples yet, but it holds some exciting potential.
Not exact matches
More work has to be done
on humans as many of the results showed up in mice
samples, however in studying the
human brains of women who had AD scientists found significantly less male fetal
tissue in their brains as in the same of women who did not have AD.
This study built
on previous research from the Sundrud lab, which showed that when TH17 cells entered the intestine in
human tissue samples, they increased the expression of a gene called MDR1.
Larger biomarker signatures can be detected with technology from CDI Laboratories, which offers microarrays of functional
human proteins (over 20,000
on a single array) to test the antibodies present in
human liquid biopsy
samples, such as blood, serum, plasma, CSF, or
tissue lysates.
These techniques include:
human tissue created by reprogramming cells from people with the relevant disease (dubbed «patient in a dish»); «body
on a chip» devices, where
human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in
humans, safely and with unsurpassed accuracy.
Dr. Wang plans to continue studying the effects of TNF and IL - 17
on melanocytes, and would like to expand the research to 3D skin models — fabricated
samples of
tissue in vitro that behave like
human skin — that would give a better visual of how the melanin production process is being disrupted by these two cytokines during skin inflammation or wound healing.
The molecular fingerprint obtained by the MasSpec Pen from an uncharacterized
tissue sample is instantaneously evaluated by software, called a statistical classifier, trained
on a database of molecular fingerprints that Eberlin and her colleagues gathered from 253
human tissue samples.
These results were also confirmed
on human cells and
tissue samples.
«Body
on a chip» could improve drug evaluation:
Human tissue samples linked by microfluidic channels replicate interactions of multiple organs..»
Livia Eberlin at the University of Texas, whose team created the device, tested it
on 253
human tissue samples (Science Translational Medicine, doi.org/cctx).
ONE - PARENT
SAMPLE SET PARENTAL GUIDANCE RULES: Maternally methylated (red dots) and paternally methylated (blue dots) regions across the
human autosomal chromosomes, based on studies of uniparental disomy samplesGENOME RES, 24:554 - 69, 2014 RESEARCHERS Kazuhiko Nakabayashi, Division Chief, Department of Maternal - Fetal Biology, National Research Institute for Child Health and Development, Tokyo, Japan; David Monk, Principal Investigator, Epigenetics and Cancer Biology Program, Bellvitge Institute for Biomedical Research ORGANISM Human METHODS Bisulfite - seq; bisulfite - chip Methylation is typically associated with the silencing of the nonexpressed allele, making it a convenient marker for imprinted genes, though it's possible for patterns of differential methylation to exist in tissues where both alleles are expre
human autosomal chromosomes, based
on studies of uniparental disomy samplesGENOME RES, 24:554 - 69, 2014 RESEARCHERS Kazuhiko Nakabayashi, Division Chief, Department of Maternal - Fetal Biology, National Research Institute for Child Health and Development, Tokyo, Japan; David Monk, Principal Investigator, Epigenetics and Cancer Biology Program, Bellvitge Institute for Biomedical Research ORGANISM
Human METHODS Bisulfite - seq; bisulfite - chip Methylation is typically associated with the silencing of the nonexpressed allele, making it a convenient marker for imprinted genes, though it's possible for patterns of differential methylation to exist in tissues where both alleles are expre
Human METHODS Bisulfite - seq; bisulfite - chip Methylation is typically associated with the silencing of the nonexpressed allele, making it a convenient marker for imprinted genes, though it's possible for patterns of differential methylation to exist in
tissues where both alleles are expressed.
Building
on 30 years of research, this achievement outlines three fundamental steps that successfully took ovarian
tissue samples and nurtured them into
human eggs to a point of full maturity.