Sentences with phrase «on humans and mice»

It was carried out on humans and mice and revealed altered intestinal bacteria and compromised glucose metabolism after relatively short trial periods.

In 1997, when few genome sequences were available, Hieter helped create XREFdb, a public database that linked the functional annotations of genes studied in model organisms with the phenotypic annotations on the human and mouse genetic maps.

The identification of these molecules led to a set of studies showing that their presence on human and mouse tumors rendered the tumors resistant to immune eradication.

Not exact matches

It has been predicted already that by 2020, we will be using gesture control on computers to stop us using our mouse and keypad, and that there will be a rise in robotics carrying out human work in an office environment.

Studies have found that the additive increases risk of certain types of cancer in mice and the International Agency for Research on Cancer classifies byproduct 4 - Mel as «possibly carcinogenic to humans.»

Hoping to learn something about how the human body defends itself against cancer, he had zeroed in on a complex regiment of lymphocytes called T cells, common to the immune systems in both mouse and man.

a comment for you, a ufo picture who the fbi acredired as a real.pedrfo castillo who was teh one that sent me that noticie, i just did no much as put my mouse on that such an ufo, and sudendly something so i called part of human appeard.

Of course, there is still a long way to go before this particular method will be tested on humans (it was tested on mice), and an even longer way to go before it'll be used in medical therapies (if it ever will translate into therapies), but one thing is becoming clear: We need not compromise our moral principles and rush into government - funded embryo - destructive research.

Data from experiments on phytic acid using mice and other rodents can not be applied to humans.

Depending on results from further behavioural studies in mice and humans, the abnormalities could then be treated in parallel with seizures.

Much of their work focuses on the house mouse (Mus musculus), which evolved to be commensal with humans: The mice are not domesticated like dogs or sheep, but they are dependent on living in and around a human settlement.

Dr. Issa's team made their discovery after first examining methylation patterns on DNA in blood collected from individuals of different ages for each of three species — mouse, monkey, and human.

«Our study shows that epigenetic drift, which is characterized by gains and losses in DNA methylation in the genome over time, occurs more rapidly in mice than in monkeys and more rapidly in monkeys than in humans,» explains Jean - Pierre Issa, MD, Director of the Fels Institute for Cancer Research at LKSOM, and senior investigator on the new study.

What's more, an ointment containing the peptide effectively treated wounds infected with methicillin - resistant Staphylococcus aureus (MRSA) and the increasingly common hospital infection bacterium Acinetobacter baumannii in mice and on laboratory samples of human skin.

The largest effect was on the number of times the mice went in and out of a sleep phase called paradoxical sleep, which resembles REM (rapid eye movement) sleep in humans, when dreams occur and memories are strengthened.

The performance of our workflow was assessed on vertebrate genome assemblies of various qualities (platypus, pig, horse, dog, mouse and human).

Dr Luis Pedro Coelho, commented: «These findings suggest that dogs could be a better model for nutrition studies than pigs or mice and we could potentially use data from dogs to study the impact of diet on gut microbiota in humans, and humans could be a good model to study the nutrition of dogs.

The book looks at fish that live in subfreezing waters, ruminating monkeys, ridiculously poisonous newts, birds that see in the ultraviolet, mice that live on lava flows, cave fish, coelacanths, bush babies, humans, and some other marvels of evolution.

Like the per gene, the new genes — dubbed RIGUI in humans and m - rigui in mice — are turned on and off in a daily cycle and may work with other genes to generate the oscillating mechanism that runs the internal clock.

By combining the pieces in one way or another, we would obtain very different circuits (as happens between mice and humans) although the basic mechanisms governing the operation are based on the same methods and available resources.

The large amounts of fat around the testes of obese mice, «could alter the environment and encourage epigenetic changes», says Teague, who presented the results at the 14th World Congress on Human Reproduction in Melbourne, Australia, this month.

The human (and all the other) genome projects were predicated on the reasonable assumption that spelling out the full sequence of genes would reveal the source of that diversity of form and attributes that so readily distinguish worm from fly, mouse, chimp and human.

In experiments on normal and MLL cells from mice and humans, the researchers demonstrated that beta - catenin is activated in cancer stem cells that prompt leukaemic blood cells to multiply.

In experiments conducted on human lung endothelial cells and in mice, the researchers showed that NS1 caused permeability of the endothelium, which lines the walls of blood and lymph vessels.

A chemical produced in the pancreas that prevented and even reversed Type 1 diabetes in mice had the same effect on human beta cells transplanted into mice, new research has found.

«There's a lot of grumbling, both in the general public and the scientific community, about how often we cure diseases in mice that never translates when we try those cures in humans,» says Felipe Sierra, director of the Division of Aging Biology at the National Institute on Aging.

Anatomical examination of human and mouse eyes was used to determine the effect of the laser on the sensitive light - detecting retina.

Dr. Aplin and Jessica Teh, PhD, his senior postdoctoral researcher at Jefferson (Philadelphia University + Thomas Jefferson University), examined the effects of a combination of two FDA - approved targeted agents on human melanomas grafted onto mice.

«For example, cancer research is heavily reliant on mouse models, and as a result we've become very good at curing mice, but that hasn't translated very well to humans.

Scientists have a promising new approach to combating deadly human viruses thanks to an educated hunch by University of California, Riverside microbiology professor Shou - Wei Ding, and his 20 years of research on plants, fruit flies, nematodes and mice to show the truth in his theory.

This take on Michelangelo's famous Sistine Chapel image symbolizes the link between human pain patients and the mouse model: The lab - designed SPR inhibitor (in green), shown within the active pocket of SPR itself (in gray with its atomic structure in colored lines), is the «bridge» between the two species.

A screen for mouse genes dependent on dHAND, a transcription factor implicated in neural crest development, identified Ufd1, which maps to human 22q11 and encodes a protein involved in degradation of ubiquitinated proteins.

«In mice it's mostly about temperament, whereas in humans it relies on factors such as education, wealth and heritage,» she says.

«If the effects of alcohol on memories to fearful responses are similar in humans to what we observe in mice, then it seems that our work helps us better understand how traumatic memories form and how to target better therapies for people in therapy for PTSD.

Early in embryonic development, both mouse and human placentas rely on the same set of ancient cell - growth genes.

«The methods for achieving transplantation tolerance differ between mice and humans, but the mechanisms that maintain it are likely shared,» said Marisa Alegre, MD, PhD, professor of medicine at the University of Chicago and co-senior author on the study.

Nevertheless, there are other measures of depression in humans that can be assessed in rodents — like the ability to enjoy pleasurable activities, which is a cardinal feature of depression in humans — you can measure that in a mouse to see how much a mouse likes to eat a sweet treat, have sex, how well it sleeps and so on.

The approach works in mice and could soon move on to human trials.

A single gene appears to play a crucial role in coordinating the immune system and metabolism, and deleting the gene in mice reduces body fat and extends lifespan, according to new research by scientists at the Jean Mayer USDA Human Nutrition Research Center (USDA HNRCA) on Aging at Tufts University and Yale University School of Medicine.

Belury and colleagues were able to tie these findings to the human tendency to skip meals because of the behavior they expected to see — based on previous work — in the mice on restricted diets.

The scientists used the new indexing method on several human cell lines and from a mouse brain to reveal the methylome of 3,282 single cells.

Green fluorescent protein labeling allowed them to see the early development pattern and show that lncND, which ordinarily is not present in mice — lncND is present only in some primates including humans — had a functional effect on development.

After chronicling the different shifts of decomposers on the mice, and seeing the same shifts operating on the humans, the researchers built a computer model using the mouse data to see whether the microbial composition could be used to predict times of death, using the humans as a test case.

In addition to the human subjects, the researchers studied the effects of BPA on pregnancy in sheep, rats and mice.

In a study that has implications for humans with inflammatory diseases, researchers from Case Western Reserve University School of Medicine and colleagues have found that, given over a six - week period, the artificial sweetener sucralose, known by the brand name Splenda, worsens gut inflammation in mice with Crohn's - like disease, but had no substantive effect on those without the condition.

«If you're looking for very specific molecular targets or pathways in the brain, and how drugs might act on them, the difference between human cells and mouse cells is significant.»

In tests on human breast cancer cells and in special immunodeficient mice with tissue grafts, the scientists found that both agents interfered with genes involved with breast cancer cell growth, resulting in more cancer cells.

Indeed, the find suggests that testing human therapies on mice and other mammalian species may have sent us down the garden path.

Mice have proven to be a particularly good model for studies relevant to humans, Magnusson said, on such topics as aging, spatial memory, obesity and other issues.

The knockout mice also did better on tests of behaviors associated with the brain's prefrontal cortex, the area that regulates complex thinking, emotions, and behavior in humans.