Sentences with phrase «on identified neurons»

In the worm, we are developing tools to monitor neuromodulation at cellular resolution in an intact brain and using them to directly measure endogenous peptide release and binding to receptors on identified neurons using real - time approaches for imaging neuropeptide signaling, in order to understand the dynamics of this process in a living animal.

Not exact matches

Next, Anderson and his colleagues used a set of genetic tools to identify exactly which neurons were responsible for the effect on aggression and to see if the gene that encodes for Tk also controls aggressive behavior by acting in that cell.

The company had identified a molecule, CGP3466B, that in laboratory tests protected neurons from degeneration by inhibiting apoptosis, and had tested it in clinical trials on patients with Parkinson's disease and amyotrophic lateral sclerosis, or ALS.

Red staining on a section through the forebrain of a mouse identifies the neurons that carry sensory information directly into primary areas.

Using machine learning algorithms, they identified which parts of the data seemed to be the timing control signal between the prefrontal cortex and the amygdala and zeroed in on the individual neurons involved in that circuit.

In a paper published June 11 in the early - online edition of Neuron, researchers at the Buck Institute for Research on Aging and the University of California, Berkeley have identified a serotonin receptor, HTR7, as a key mediator of eczema and other forms of itch.

In order to identify genes specific for the sensory neurons of Aplysia, a miniaturized differential screening method based on the polymerase chain reaction and applicable to small amounts of tissue was used.

Even before the recent genome work, researchers had characterized some of the components of black widow venom, identifying two seemingly unique families of proteins: latrotoxins, which act on neurons; and latrodectins, whose role in venom remains unclear.

Now that the biologists had identified one site — out of many — housing neurons that activated selectively for social encounters, they listened in on the goings - on by placing very fine electrodes in proximity.

Once selective neurons for Bill Clinton and the lion are identified, a subject can be asked to imagine Bill Clinton holding the lion on his lap.

Chandrashekar says the group is now working on identifying which genes each neuron expresses, which will help to pin down their function.

In the featured article published online on April 5 in Neuron, the researchers also conclude that potential treatments targeting the transport disruptions they identified in Huntington's disease neurons may also work for other neurodegenerative diseases, such as ALS and forms of dementia.

To start, the scientists examined previous experiments and identified several transcription factors — managerial proteins that switch on the activity of large sets of genes — that seemed crucial to the ability of immature neurons to develop into adult sensory neurons.

«Following on the work of TSRI Professor Ardem Patapoutian, who has identified many of the genes that endow these neurons with selective responses to temperature, pain and pressure, we have found a way to produce induced sensory neurons from humans where these genes can be expressed in their «normal» cellular environment,» said Associate Professor Kristin K. Baldwin, an investigator in TSRI's Dorris Neuroscience Center.

Focusing their search on receptors not known to respond to any odor, the researchers identified one family of genes that appeared to be expressed in olfactory neurons but not in other tissues.

Lee and Bonin began by identifying neurons in the mouse visual cortex that responded to particular visual stimuli, such as vertical or horizontal bars on a screen.

Researchers working in the lab of Carnegie Mellon University neuroscientist Aryn Gittis, have identified two groups of neurons that can be turned on and off to alleviate the movement - related symptoms of Parkinson's disease.

The George lab has made seminal contributions to the field including: discovering a novel population of neurons in the brain of humans, rats and mice that are involved in nicotine dependence, identifying neuronal ensembles responsible for nicotine and alcohol addiction, and unveiled the cellular and molecular changes associates with long term use of nicotine, cocaine, methamphetamine and alcohol use on the brain.

Abstract Any type of neurons can be easily identified based on its electrophysiological activity, such as its pattern of spontaneous activity, the shape of its action potential, its dendritic integration, etc..

Three groups independently studying people with narcolepsy identified antibodies against the same protein, tribble 2, that's found on hypocretin neurons.

Almost all of these small neurons were identified to be cerebellar granule cells based on their morphology and that they were stained by anti-neural cell adhesion molecule L1 (Fig. 1A)[19].

Working with Ye, postdoctoral fellow Sung - Wuk Jang identified a compound called 7,8 - dihydroxyflavone that can duplicate BDNFâ $ ™ s effects on neurons and can protect them against damage in animal models of seizure, stroke and Parkinsonâ $ ™ s disease.

Subsequently, Shatz and colleagues identified a receptor on neurons called PirB (paired immunoglobulin - like receptor B), through which MHC molecules normally delivered the «off» signal.

Based on basic transcriptional studies of midbrain dopamine neurons, Dr. Kim's lab identified the orphan nuclear receptor Nurr1 as a potential drug target of Parkinson's disease (PD) to develop novel drug candidates for neuroprotective and mechanism - based therapeutics.

Triple - labelled preparations in which mDA neurons were identified by TH staining revealed that BMPR2 was expressed on, but not limited to, mDA neurons in cultures of the E14 rat VM (Figure 1A, B).

In 2002, she identified another four genes that promote social feeding and which are found on neurons responding to stressful stimuli such as pain and noxious chemicals.

Using genetic tools to turn on and off different parts of the brain, the scientists were able to identify specific brain circuits and neurons (brain cells) involved in the food coma experience.