Sentences with phrase «on immune system cells»

The study included 124 newly diagnosed patients at 25 clinical trial sites in the U.S. Two - thirds of the patients were treated with ICT - 107, an experimental vaccine based on immune system cells called dendritic cells that were exposed to six synthetic proteins, or antigens, known to be involved in GBM development.

Not exact matches

The medicines, which help unleash the immune system on cancer cells, were tested in patients with advanced lung cancer.

The Parker Institute for Cancer Immunotherapy will focus on the emerging field of cancer immunotherapy, which harnesses the body's immune system to fight cancer cells.

The institute, which includes over 40 laboratories and more than 300 researchers, said the research would focus on modifying a patient's own immune system T - cells to target a tumor, studying ways to boost patient response to current immunotherapy drugs.

Hoping to learn something about how the human body defends itself against cancer, he had zeroed in on a complex regiment of lymphocytes called T cells, common to the immune systems in both mouse and man.

The Napster founder and former Facebook president created the Parker Institute for Cancer Immunotherapy, which will focus on using the body's immune system to combat cancer cells.

It's a type of cancer immunotherapy, which harnesses the body's immune system to take on cancer cells.

This is the group of genes which act as the immune system markers on cells, protecting them from being attacked by the system's anti-bodies.

The old episode on the immune system took us into the blood vessels and showed us the drama of white blood cells marking strep bacteria for death, then engulfing and digesting them.

Psoriasis (Ps) and psoriatic (so - rye - AT - ick) arthritis (PsA) are conditions of the immune system that affect the normal production of healthy skin cells on the body.

A decade ago a drug based on an internal protein of the flu virus, called NP (for nucleoprotein), set the immune system's killer T cells into action, but it only partially protected mice from the flu.

They use molecules on the bacteria's surfaces as reins, to ride towards host cells, or backstage passes to sneak past the immune system.

«Chronic inflammation of the intestine is thought to be caused by abnormal interactions between gut microbes, intestinal epithelial cells and the immune system, but so far it has been impossible to determine how each of these factors contribute to the development of intestinal bowel disease,» said Hyun Jung Kim, Ph.D., former Wyss Technology Development Fellow and first author on the study, speaking about the limitations of conventional in vitro and animal models of bacterial overgrowth and inflammation of the intestines.

New research from Australian and Singaporean scientists has revealed how immune cell «spies» are created, providing clues on how the immune system could be manipulated to better fight disease.

Moreover, in the aftermath of surgery, the immune system concentrates most of its efforts on healing the surgical wound, lowering its guard against cancer cells.

As might be expected of an autoimmune disease, where the immune system turns on healthy tissue, all the genes play a role in controlling the growth and multiplication of cells in the immune system.

«Current therapies in clinical trials are focused on targeting genetic changes in tumors and helping to boost one's immune system to fight the cancer cells.

The immune system depends on molecules called T cell receptors on the surface of T cells to recognize and respond to foreign antigens from virus - infected cells, tumors and other threats.

The Cologne molecular biologist is an expert on root - colonizing fungi and the plant immune system, the Würzburg chemist is a specialist for sugar molecules and their functions in cells and organisms.

Dr Tomi Pastinen, senior author on the second study, from McGill University said: «We have created an expansive, high - resolution atlas of variations that deepens our understanding of the interplay between the genetic and epigenetic machinery that drives the three primary cells of the human immune system.

Dendritic cells are intelligence - gathering immune cells, gathering information on viruses, bacteria, cancer and fungi to aid the immune system in fighting disease.

In effect, PD - 1 may actually help to preserve a «reserve force» of T cells that can fight on later in the long - term cellular war between the immune system and foreign invaders or tumors.

The protein puts the immune system's brakes on, keeping its T cells from recognizing and attacking cancer cells, said Dr. Antoni Ribas, the study's principal investigator and a professor of medicine in the division of hematology - oncology at the David Geffen School of Medicine at UCLA.

The removal of these components might be expected to unleash an assault by the immune system on cancer cells left after surgery.

«Suppressing a progenitor from creating the subtype of dendritic cells implicated in causing lupus, for example, could be an efficient way of treating autoimmune diseases while minimising the impact on the rest of the immune system.

The researchers found that production of this mucus lining depends upon a single immune system regulator — the NLRP6 inflammasome — that controls mucus secretion by cells in the wall of the intestine, just like turning on a faucet.

«We hypothesized that individual mutations in viral genes could be expected to have a range of effects on the virus's ability to replicate, to infect new cells and escape the immune system,» Carlson says.

In this study, the SIgN team discovered for the first time that the integrity of p53 affects the production of a special cell surface protein called Major Histocompatibility Complex (MHC) class I. MHC class I molecules on the cancer cell surface serve as targets for the immune system.

Patients with metastatic non-small cell lung cancer will always progress after chemotherapy, so most patients go on to be treated with immunotherapy, a type of therapy that uses the body's immune system to fight cancer.

George Klinman, an FDA immunologist and lead author of the report, speculates that dangling the protein in front of the immune system in an unusual setting — on a muscle cell — might be what triggers the inappropriate response.

In a study published in the journal Science, an international collaboration of investigators from Dana - Farber, Harvard Medical School, Boston Children's Hospital, and the University of Strasbourg uncovered a mechanism that allows key immune system cells to keep a steady rein on their more belligerent brother cells, thereby protecting normal, healthy tissue from assault.

Together, the two studies advance the idea that gut microbes play a role in turning the immune system against nerve cells, causing MS.. It will take a lot more work to develop cures or preventive strategies based on that, but the research raises the intriguing possibility of treating an often - devastating disease with something as low - tech as fecal transplants or probiotics.

What they discovered was that an inflammatory factor known as TGF - beta (transforming growth factor - beta) can give cancer cells properties of immune cells by supplying the surface of the cancer cell with a receptor that normally only exists on the white blood cells that travel through the lymphatic system.

One advantage of this method is that it only activates a certain type of immune cell, the dendritic cell or T - cell, and only in one part of the body, near the draining lymph nodes or tumor, which helps cut down on the system - wide side effects often seen with chemotherapy.

The system, says Brahmer, provides a kind of «handshake» or connection between receptors on immune cells, called PD - 1, and their sister - proteins on tumor cells, called PD - L1.

By releasing the brakes that tumor cells place on the immune system, researchers are developing a new generation of more powerful treatments against malignancy

EMD Serono, Kirschbaum says, «focuses on the development of targeted cancer therapies on three therapeutic platforms: targeting the tumor cell, the tumor environment, and the immune system.»

Researchers are developing many different versions of CAR - T cell therapies, but the basic premise is the same: Doctors remove a patient's T cells (immune system cells that attack invaders) from a blood sample and genetically modify them to produce artificial proteins on their surfaces.

The drug blocks CTLA - 4, a protein receptor on the surface of T - cells that serves as a molecular stop sign, preventing the immune system from going into overdrive.

What's more, the studies suggest how our gut microbes make the immune system turn against nerve cells — a finding that could lead to treatments, like drugs based on microbial byproducts, that might improve the course of the disease.

Patients received a tandem of lenalidomide, a drug that kills tumor cells, blocks blood vessel growth, and acts on the immune system, and dexamethasone, an anti-inflammatory agent, plus one of three new agents:

Allison's seminal work focuses on a protein called CTLA - 4, which reins in T - cell activation in the immune system.

The disease commonly starts in childhood and causes the body's own immune system to attack and destroy the insulin - producing cells in the pancreas, leaving the patient dependent on life - long insulin injections.

Although some cancers — particularly those that are rife with mutations like lung cancer or melanoma — create more tangible targets on the surface of cells for the immune system to recognize and attack, other malignancies such as prostate and pancreatic cancers have proved more intransigent.

So Swanton is focusing on immunotherapies — strategies that help the immune system to recognize and destroy cancer cells.

On encountering the TB bacillus, receptors on immune - system scavenger cells known as macrophages stimulate the conversion of circulating vitamin D to its active form, which produces a peptide that destroys the bacilluOn encountering the TB bacillus, receptors on immune - system scavenger cells known as macrophages stimulate the conversion of circulating vitamin D to its active form, which produces a peptide that destroys the bacilluon immune - system scavenger cells known as macrophages stimulate the conversion of circulating vitamin D to its active form, which produces a peptide that destroys the bacillus.

In particular, it has evolved to show itself three to nine months after infection, allowing its own destruction by displaying antigens on its cell surfaces so the dog's immune system can destroy it.

Interferons are molecules produced by cells in response to viral or bacterial infection, and which act on neighboring cells to prevent the spread of the infection, shut down protein synthesis, and activate the immune system.

Most importantly, the doxorubicin - decorated diamonds had no effect on white blood cell count, an indicator of immune system activation that's often the deciding factor in whether a patient can continue chemotherapy.

Previous studies have found evidence that IL - 27 has a moderating effect on the Th2 response, and in general, keeps T - cells — the «battle tanks» of the immune system — from causing too much damage.