Sentences with phrase «on in a human patient»

«A fundamental weakness inherent in this approach is that one makes assumptions concerning the relevance of the phenotypes and the mechanisms underlying them to the actual disease process going on in a human patient,» Gusella said.

Not exact matches

Drugs that worked in the microtumor worked 88 percent of the time on humans, and drugs that failed in the microtumor failed 100 percent of the time in the patient.

In 2000, Medarex began its first phase of human testing on its new «CTLA -4-blockade» — in patients who had either prostate cancer or metastatic melanoma, a deadly form of skin canceIn 2000, Medarex began its first phase of human testing on its new «CTLA -4-blockade» — in patients who had either prostate cancer or metastatic melanoma, a deadly form of skin cancein patients who had either prostate cancer or metastatic melanoma, a deadly form of skin cancer.

Then, through its human - trained algorithms, it makes split - second decisions on triaging patients and getting them where they need to go — prepping the surgical team ahead of time in cases like Rodney's.

'' «At PMV Pharmaceuticals, we are targeting the most frequently mutated gene in human cancer (p53) to make an unprecedented impact on cancer patients» lives.

As we read this history, the furor over stem cells was fueled by numerous factors: the near - universal human desire for magic; patients» desperation in the face of illness and their hope for cures; the belief that biology can now do anything; the reluctance of scientists to accept any limits (particularly moral limits) on their research; the impact of big money from biotech stocks, patents, and federal funding; the willingness of America's elite class to use every means possible to discredit religion in general; and the need to protect the unlimited abortion license by accepting no protections of unborn human life.

A general summary was provided by ethics experts who testified before then - Congressman Albert Gore's Committee on Science and Technology in 1982: (1) Though risks in experimentation are inevitable, a strong bias toward the sacredness of human life requires the highest regard for the patient or subject.

The human material on which the demonstration has been made has so far been rather limited and, in part at least, eccentric, consisting of unusually suggestible hypnotic subjects, and of hysteric patients.

«Thus, also in our century, the Lord, the Holy Spirit, has given us new initiatives with new aspects of Christian life: On being lived by human persons with th ``... If the movements are really gifts of the Holy Spirit, they integrate and serve the Church, and in the patient dialogue between pastors and movements a fruitful form is born, in which these elements become edifying elements for the Church of today and tomorrow

In order to protect infant safety and ensure the patient and human rights of mothers and babies, we have built a non-profit organization committed to: (1) the study of exclusive breastfeeding complications that can result in brain injury and, in the most severe instances, death; and (2) raising public awareness to signs of infant hunger and the consequences that can result based on peer - reviewed researcIn order to protect infant safety and ensure the patient and human rights of mothers and babies, we have built a non-profit organization committed to: (1) the study of exclusive breastfeeding complications that can result in brain injury and, in the most severe instances, death; and (2) raising public awareness to signs of infant hunger and the consequences that can result based on peer - reviewed researcin brain injury and, in the most severe instances, death; and (2) raising public awareness to signs of infant hunger and the consequences that can result based on peer - reviewed researcin the most severe instances, death; and (2) raising public awareness to signs of infant hunger and the consequences that can result based on peer - reviewed research.

The National Human Research Protections Advisory Committee (NHRPAC), a committee of scientists, lay patient advocates, lawyers, professional society members, and ethicists, previously advised DHHS on research matters, but — in a politically charged decision — its charter was allowed to expire recently.

«If this technology can be scaled to human - size grafts, patients suffering from renal failure, who are currently waiting for donor kidneys, could theoretically receive an organ grown on demand,» says Harald Ott, head of the team that developed the rat kidneys at the Massachusetts General Hospital in Boston.

At the patient safety charity, Safer Medicines, we believe this goal is most likely to be achieved through a greatly increased focus on human, rather than animal, biology in preclinical drugs tests.

Besides its potential application in human patients, the newly developed skin tissue also could be used as an alternative to testing cosmetics on animals, the researchers said.

GTC recognized the need to demonstrate on its own the potential for the technology and, in the late 1990s, began a clinical trial of human antithrombin for patients undergoing bypass surgery who develop resistance to the anticoagulant drug heparin.

Although the Harvard criteria were based on zero patients and no experiments were conducted either with humans or animals, they soon became the standard for declaring people dead in several states, and in 1981, the Uniform Determination of Death Act (UDDA) was sanctioned by the National Conference of Commissioners on Uniform State Laws.

These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed «patient in a dish»); «body on a chip» devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy.

In 2017, they'll try the device on human participants — paralyzed patients who will use stentrodes to control mechanical exoskeletons.

«Most previous research into ways of delaying the onset of HD symptoms have focused on studying the mutant protein in cells or in animal models, but the relevance of abnormalities in those systems to what actually happens in patients remains a huge assumption,» says James Gusella, PhD, director of the Center for Human Genetic Research (CHGR) at Massachusetts General Hospital (MGH), corresponding author of the Cell paper.

This take on Michelangelo's famous Sistine Chapel image symbolizes the link between human pain patients and the mouse model: The lab - designed SPR inhibitor (in green), shown within the active pocket of SPR itself (in gray with its atomic structure in colored lines), is the «bridge» between the two species.

Marc Wolfson, public affairs specialist on emergency preparedness for the Department of Health and Human Services, isn't so confident: «We can develop the best countermeasures in the world, but if they're not there in time to help treat the patient, then they're not effective.»

In contrast, observations in humans report on dozens of patients and an order of magnitude more data than in monkeys.&raquIn contrast, observations in humans report on dozens of patients and an order of magnitude more data than in monkeys.&raquin humans report on dozens of patients and an order of magnitude more data than in monkeys.&raquin monkeys.»

Dr. Frankel is currently directing or co-directing projects related to the ethical and policy implications of human germ - line interventions, the responsible use of animals in biomedical and behavioral research, improving patient safety and reducing errors in health care, the ethical dimensions of the Human Genome Diversity Project, the uses of anonymity on the Internet, and intellectual property and ethical standards for electronic publishing in scihuman germ - line interventions, the responsible use of animals in biomedical and behavioral research, improving patient safety and reducing errors in health care, the ethical dimensions of the Human Genome Diversity Project, the uses of anonymity on the Internet, and intellectual property and ethical standards for electronic publishing in sciHuman Genome Diversity Project, the uses of anonymity on the Internet, and intellectual property and ethical standards for electronic publishing in science.

However, in tests on tissues removed from 253 human cancer patients, the MasSpec Pen took about 10 seconds to provide a diagnosis and was more than 96 percent accurate.

«Applying a blocker might help to reduce the negative effects on the human heart that are caused by medium - chain fatty acids, especially in patients with increased fatty acid levels in blood,» concludes Hatt.

In order to test their hypothesis in a model that more closely mimicked human disease, the researchers also tested the two drugs side - by - side on slices of tumors removed from patients during radical prostatectomIn order to test their hypothesis in a model that more closely mimicked human disease, the researchers also tested the two drugs side - by - side on slices of tumors removed from patients during radical prostatectomin a model that more closely mimicked human disease, the researchers also tested the two drugs side - by - side on slices of tumors removed from patients during radical prostatectomy.

The same printer technology that sits on your desk could soon be a common fixture in rebuilding human tissue, treating burns by laying down layers of a patients» own skin or even rebuilding whole organs.

Their findings, reported in Nature Communications, may shed light on human lung disease, in particular, the mechanism behind non-familial pulmonary hypertension in patients with conditions such as emphysema and pulmonary fibrosis.

On the basis of those results, at least one company is attempting to replicate the effect in humans using blood plasma from healthy young people to treat patients with Alzheimer's disease.

These images provide the first 3D ultrastructural details on HIV infection and virus production in a setting that closely resembles the gut of human patients.

Although McAlpine cautions that further work and extensive testing would need to be done before the technology could be used on a patient, he said the ear in principle could be used to restore or enhance human hearing.

On the other hand patients with DRB1 * 04:01 have a better clinical outcome in the short - and long - term suggesting that human leukocyte antigen (HLA) analysis and screening for SLA / LP antibodies should be integrated in the clinical routine for AIH diagnosis.

Since the thyroid absorbs nearly all of the iodine in the human body, radioactive iodine given to a patient will concentrate in thyroid cancer cells, killing them with little effect on the rest of the body.

«Fasting blood sugar is easily measured and our findings suggest that it could serve as a useful measure in advising some patients on the type of diet that is most beneficial for their weight loss,» said senior author Sai Krupa Das, Ph.D., scientist in the Energy Metabolism Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University in Boston.

In the new work, the researchers added serum from Finnish narcolepsy patients who had received Pandemrix to cells that were engineered to display human hypo cretin receptor 2 on their surface.

«Liver cancer is on the rise worldwide, and in human studies we've now seen that patients can progress from fatty liver disease to liver cancer without any middle steps such as cirrhosis,» says David Moore, a professor of molecular and cellular biology, who led the study with Associate Professor Loning Fu, both at Baylor.

«If dexamethasone works well in humans, we could potentially use it to prevent fearful memories in soldiers on the battlefield, patients in emergency rooms, or anywhere else where healthcare providers provide treatment within hours of traumatic events.»

A clinical trial in humans of a vaccine based on Ab antibodies was halted in 2002 because 5 percent of the patients developed encephalitis.

Beilhack and colleagues found that a slightly modified version of STAR2 has a similar effect on human T reg cells, suggesting that the approach could also prevent GvHD in leukemia and lymphoma patients after bone marrow or hematopoietic stem cell transplants.

«Based on this research, we are now conducting a first - in - human study combining the PARP inhibitor with radiation and chemotherapy in patients with locally advanced pancreatic cancer, with an ultimate goal of improving survival rates and treatment outcomes,» said Tuli.

The mice show many of the symptoms that human patients do, and so they were an especially good candidate to test iPS cells» abilities, says stem cell researcher Rudolf Jaenisch of the Whitehead Institute for Biomedical Research and the Massachusetts Institute of Technology, both in Cambridge, who collaborated with Townes on the project.

Next steps include He's collaboration with Piedmont Atlanta Hospital to retrieve T cells, liver cancer cells and healthy tissue normally removed from patients during surgery, put the mouse receptor genes on these T cells and monitor in a dish both how those cells now fight the tumor and react to healthy human tissue.

If I recall correctly, his paper had been published in Science, and it had been fast - tracked in what seemed transparently to be part of a political effort to sell the public on human cloning to produce patient - specific embryonic stem cells.

In their new paper in Journal of Immunology, Mandy Ford, Craig Coopersmith and colleagues show that 2B4 levels are increased on certain types of T cells (CD4 + memory cells) in human sepsis patients and in a mouse model of sepsis called CLP (cecal ligation + punctureIn their new paper in Journal of Immunology, Mandy Ford, Craig Coopersmith and colleagues show that 2B4 levels are increased on certain types of T cells (CD4 + memory cells) in human sepsis patients and in a mouse model of sepsis called CLP (cecal ligation + puncturein Journal of Immunology, Mandy Ford, Craig Coopersmith and colleagues show that 2B4 levels are increased on certain types of T cells (CD4 + memory cells) in human sepsis patients and in a mouse model of sepsis called CLP (cecal ligation + puncturein human sepsis patients and in a mouse model of sepsis called CLP (cecal ligation + puncturein a mouse model of sepsis called CLP (cecal ligation + puncture).

OpenBiome was founded to expand safe access to fecal transplantation for patients with recurrent C. difficile infection and to catalyze research on the role of the microbiome in human health.

These instruments have formed the foundation for the biochemistry cores of two NIH Centers of Excellence (the NIAAA - funded TSRI Alcohol Research Center and the National Institute on Drug Abuse [NIDA]- funded Scripps Center for Cannabis Addiction Neurobiology) and have directly supported other ongoing projects at TSRI (the Methamphetamine NeuroAIDS Research Program, NIDA - funded projects on immunopharmacotherapy [Taffe and Janda laboratories], a project with Dr. Steve Poceta to measure human lumbar cerebrospinal fluid in Parkinson's patients with Restless Leg Syndrome, and a U.S. Army grant), as well as assisting non-TSRI collaborators from The Sanford - Burnham Institute, The Salk Institute, and elsewhere.

Dr. Sonntag studies this concept on the molecular and cellular level using a translational research approach that integrates the analysis of human material, such as postmortem brains, primary cell systems, and neural cell populations generated from patients» - or healthy individuals» - derived induced pluripotent stem cells (iPSC), or induced neurons (iNs), in combination with molecular, biochemistry, and lentivirus - mediated gene - engineering technologies.

Of the 22 patients whose tumors successfully grafted, six died before data from the mice were available, but in 13 of the remaining 16 cases, there was a positive correlation between mouse and human results.2 In a second study, performed in collaboration with Manuel Hidalgo of the Spanish National Cancer Research Center, the team found that 6 of 13 patients with advanced solid tumors who were treated based on results from personalized PDX mice had partial tumor remissions, even in cases where genetic sequencing of the tumor showed no actionable mutationsin 13 of the remaining 16 cases, there was a positive correlation between mouse and human results.2 In a second study, performed in collaboration with Manuel Hidalgo of the Spanish National Cancer Research Center, the team found that 6 of 13 patients with advanced solid tumors who were treated based on results from personalized PDX mice had partial tumor remissions, even in cases where genetic sequencing of the tumor showed no actionable mutationsIn a second study, performed in collaboration with Manuel Hidalgo of the Spanish National Cancer Research Center, the team found that 6 of 13 patients with advanced solid tumors who were treated based on results from personalized PDX mice had partial tumor remissions, even in cases where genetic sequencing of the tumor showed no actionable mutationsin collaboration with Manuel Hidalgo of the Spanish National Cancer Research Center, the team found that 6 of 13 patients with advanced solid tumors who were treated based on results from personalized PDX mice had partial tumor remissions, even in cases where genetic sequencing of the tumor showed no actionable mutationsin cases where genetic sequencing of the tumor showed no actionable mutations.3

Andrology Laboratory and Sperm Bank; Center for Advanced Research in Human Reproduction, Infertility, and Sexual Function: Research work in the Reproductive Research Center is mainly focused on elucidating the molecular mechanism associated with male and female infertility and on studies involving the management of sexual dysfunction in male and female patients following urologic surgeries.

About OpenBiome OpenBiome is the first public stool bank, founded to expand safe access to fecal transplantation for patients with recurrent C. difficile infection and to catalyze research on the microbiome's role in human health.