Sentences with phrase «on key genes»

But the message receiver can turn on the key genes and make the colors light up by pressing the nitrocellulose paper into an agar plate containing a chemical trigger that activates expression of the fluorescent proteins.

Tattersall explains how epigenetic effects on key genes cascade to produce radical morphological changes in an eye blink, and why our unusual thinking style, far from being the perfected product of long - term selective pressures, was bootstrapped out of existing abilities barely 100,000 years ago.

One study shows that curcumin turns on a key gene signal involved with nerve protection, which boosts antioxidant enzymes in the brain and helps to prevent neurodegeneration.

Not exact matches

However, this first phase fairly rapidly was superseded by a second, in which Sewall Wright and Theodosius Dobzhansky were the two key figures, both of them insisting on the importance of thinking of populations of many genes, as well as populations of many individuals.

We develop higher - yielding varieties by focusing on key physiological plant traits and genes expected to increase yield potential.

What was key on the play is that it was originally ruled a touchdown, meaning referee Gene Steratore and the league office needed to see indisputable evidence to justify an overturn of the call on the field.

Studies involving mice also helped to answer a key question: What turns on the activity of the per and tim genes in the first place?

The key insight for building such drugs came to Tim Tully, founder and chief science officer of Helicon, when his team at Cold Spring Harbor Laboratory on Long Island stumbled upon the molecular switch: a gene called CREB, which is involved in converting short - term memories into long - term ones.

While most of biology and medicine focus on the key roles genes and chemicals play in the formation and control of living systems, the spatial arrangement of the components that make up those systems and the physical forces they experience are being increasingly recognized as equally important.

One key gene encodes the making of a receptor called TREM2, a docking site for molecules on the surface of microglia and other innate immune cells.

Indeed, the group found that the affected gene, named left - right dynein (lrd), comes on in the «node» — a key source of patterning signals — just before the appearance in the mouse embryo of the first known left - right asymmetries, the left - sided expression of two genes called nodal and lefty.

The key objective was to see how exam scores varied from the national average depending on whether twins had the same genetic make - up, as identical twins do, or shared only half of their genes, which is true for non-identical twins.

A decade of post-genomic biology has also focused new attention on the regions outside protein - coding genes, many of which are likely to have key functions, through regulating the expression of protein - coding genes and by making a slew of non-coding RNA molecules.

That enzyme regulates the way key learning and memory - related genes turn on and off during development.

«Our findings show that the gene mutation that causes Werner syndrome results in the disorganization of heterochromatin, and that this disruption of normal DNA packaging is a key driver of aging,» says Juan Carlos Izpisua Belmonte, a senior author on the paper.

In addition to its effect on the insulin pathway, the let - 7 microRNA appears to drive these metabolic and functional changes by acting on other key gene regulators.

The fact that so many proteins interact with the 26 bait proteins indicates that these original proteins play key roles in a complex process that wasn't apparent on the level of the «suspect» genes.

The egg's very structure, its scaffolding of proteins that guide the chromosomes during cell division, may also play a key role in turning on the necessary genes.

Alternatively, epigenetic changes — changes in the way genes are switched on and off — influencing key genes, induced by sex hormones, may be responsible.

The map is a key tool that geneticists rely on to find disease genes and identify the functional genetic variations at the core of human diversity.

This caused two key genes normally activated solely on the left side of the body to be expressed on the right side, the team reports in the 4 July issue of Nature.

The full readout of what genes are on and off in dermal papilla cells has never been collected before, so researchers now have a new list of thousands of genes to study further that may play key roles in hair follicle development.

The Eischen group focused on the role of long non-coding RNAs (lncRNAs), which have emerged as key regulators of genes.

Scientists have captured atomic level snapshots showing how one key enzyme modifies a protein involved in turning genes on or off inside cells.

«Scientists determine structure of enzyme linked with key cell - signaling protein: Findings aid understanding of how modifications to cell - signaling protein affect its action in turning genes on and off.»

To determine how similar a person's fingertip bacteria are to bacteria left on computer keys, the team took swabs from three computer keyboards and compared bacterial gene sequences with those from the fingertips of the keyboard owners.

Years of diabetes research carried out on mice whose DNA had been altered with a human growth hormone gene is now ripe for reinterpretation after a new study by researchers at KU Leuven confirms that the gene had an unintended effect on the mice's insulin production, a key variable in diabetes research.

By flipping on three key genes in cells from the lower stomach, scientists may have engineered a viable replacement for those beta cells.

They found what they were looking for on the CNGA3 gene, which encodes a cyclic nucleotide channel and plays a key role in transducing visual signals.

PARIS — As scientists race to finish a rough draft of the human genome, a European consortium is about to launch an effort to pinpoint every key spot in our genetic code where cells turn genes on and off by adding a molecule called a methyl group.

Another key finding was observing the inhibitor effect on tumor models with a gene PTEN deficiency as a biomarker — of huge interest because PTEN, a tumor suppressor, is known to be defective in as many as half of all advanced solid tumor cancers.

A University of Toronto (U of T) study on fruit flies has uncovered a gene that could play a key role in obesity in humans.

«People have historically thought of genes as being a key way that parents transmit their advantages and disadvantages to their kids, and this casts some serious doubt on that,» Rauscher said.

«Cell biologists discover on - off switch for key stem cell gene.»

This finding matters because — by impacting on who mixes their genes with whom — choosiness is a key factor shaping the biodiversity of species.

«We know that most of these risk variants on their own play little role in the development of MS.. But mapping the collection of genes associated with MS represents an important advance in efforts to identify the key mechanisms behind its development,» Dr Harbo says.

By disabling the gene for that key protein in test animals, the scientists were able to home in on the mechanism by which that brain region, known as the suprachiasmatic nucleus or SCN, becomes the body's master clock while the embryo is developing.

Light played a key role in the experiment because it allowed the researchers to switch on genes that they had added to the yeast cells.

The senior researchers of the study, Martin Eilers and Juha Klefström are excited about the concept that Myc's ability to turn off rather than turn on genes is a key to cell death: «It is much easier to bring cellular activities down than up with the existing drugs.

«The key lesson we learned was that the genes that are destined to be turned on specifically in the fertilized egg are covered by this unique chromatin domain structure,» says Ren.

Prompted by those results, 2 years ago Floyd Romesberg, a chemist at the Scripps Research Institute in San Diego, California, and colleagues reported that both in vitro and animal studies showed that a gene called LexA serves as one of the key «on» switches for the error - prone DNA polymerase.

Based on studies of other genes related to FOXP2, the authors suggest that the loss of functioning protein from one copy of this gene might disrupt the proper growth of key speech and language structures in the brain.

These assessments, which take into account the gene drive's characteristics, effects on humans and the environment, and local values and governance, are a key tool for determining a gene drive's impacts.

Although the teams took very different approaches to solve the mystery of how those limbs vanished, both came up with similar results: Mutations in DNA located near a gene key to limb formation keep that gene from ever turning on, they report today.

A key future experiment will involve attaching a malaria - resistance gene to the Myd88 code engineered to get switched on in the offspring during early development.

Although LGDs can impair the function of key genes, and in this way have a deleterious impact on health, this is not always the case.

The gene Gas5Â acts as a brake on steroid hormone receptors, making it a key player in diseases such as hormone - sensitive prostate and breast cancer.

This technology is based on differential expression of key gene transcript variants (isoform - level gene expression) and was originally tested on a vast collection of glioblastoma samples made available by the University of Pennsylvania.

A variant in a region of the genome that is not coding for a protein can have a relatively large effect on a gene regulating bone health,» says Dr. Douglas Kiel, whose NIH - funded team at Hebrew SeniorLife and Harvard Medical School played a key role in the effort.

«The bioinformatics tools have matured to the point that we can now find the proverbial «needle in a haystack,» meaning we can now identify genes and pathways that are unique to pathogenic microbes, which will focus future research efforts on these key pathogen - specific features,» Fouts said.