Sentences with phrase «on kinase»

Since 2007 he has focussed his research on kinase structural biology and structures of key proteins involved in cell signalling.

We study the signal transduction pathways regulating cell growth and proliferation, with an emphasis on kinase enzymes.

She moved to Oxford in 2012 to work at the SGC, initially working in Alex Bullock's Growth Factor Signalling group to study E3 ubiquitin ligase complexes, and subsequently joining Stefan Knapp's kinase team to focus on kinase structural biology and inhibitor discovery.

This review focuses on kinase inhibitors that are in the clinic or in clinical trials and for which structural information is available.

Zeroing in on this kinase was encouraging, Goga said, because other researchers have shown that genetic - knockout mice that lack the entire family of PIM kinases are slightly smaller than normal mice, but «basically fine,» indicating that a drug targeting just PIM1 may have manageable levels of toxicity in breast cancer patients.

John E. Burke's work focuses primarily on the kinases and phosphatases that catalyze the phosphorylation and dephosphorylation of lipid phosphoinositides.

The anti-inflammatory and immunostimulatory effects of the tocopherols are related, not only to their antioxidant activity, but to their modulation of cell signaling via their effects on kinases.1

Not exact matches

(I keep waiting for the synthesis companies to make recommendations on their Web sites the way that Amazon and Netflix do: «If you liked the metalloprotease, you'll love this cyclin - dependent kinase!»)

Cyclic adenosine monophosphate (cAMP)- dependent protein kinase, labeled with fluorescein and rhodamine on the catalytic and regulatory subunits, respectively, was injected into Aplysia sensory neurons either in culture or in intact cell clusters.

Investigators focused on the tumor suppressor liver kinase B1 (LKB1), a protein that controls cell growth and metabolism.

Metformin, which acts on the AMP kinase enzyme, lowers blood sugar and improves insulin sensitivity, thus altering insulin production.

Focusing on adiponectin led Dr. Medina's lab to protein kinase A or «PKA» — a protein that, when activated by adiponectin, suppresses the fatty acids that myeloma cells need, leading to their demise.

The researchers observed the effect of the synthetically produced molecule, JK - 31, on the growth and proliferation of a model human breast cancer cell line and found that it effectively blocked the protein cyclin - dependent kinase 1 (CDK1), which plays a key part in the process of the division of cancer cells, and therefore inhibited the proliferation of the cells.

And none of these kinase inhibitors have yet been rigorously tested in a head - to - head comparison with the protein therapies already on the market.

These results not only show promise on a new targeted therapy to treat this malignancy, as PI3K inhibitors are already used in the clinical practice, but also unravel a new function of the PI3K kinase in cancer biology through its role in promoting metastasis.

The microscope images show that R2TP is a large platform capable of putting HSP90 in contact with the kinases on which HSP90 must act.

These new insights into how the kinase is turned on provides a starting point for designing molecules to inhibit it, Muir said.

The research has also investigated the role of Rho - kinase inhibition on cellular - scale protein expression and stimulation of cellular differentiation of fibroblast cells.

The researchers targeted mTOR with an experimental drug based on a prototype first designed by Shokat, a chemist and an expert in designing molecules to target this type of protein, called a kinase.

In his research, Juha Piltti has focused on a small molecule, which causes Rho - kinase inhibition and regulation of specific down - stream protein pathways involved in many physiological processes.

Half of all melanomas harbor an activating mutation in the BRAF gene that turns on the cancer signaling pathway in cells known as the MAP kinase pathway.

Based on the current study results, the team believes a particular enzyme, «dual specificity tyrosine - regulated kinase - 1a (DYRK1A),» is the likely target of harmine.

(Moussa is listed as an inventor on a patent application that Georgetown University filed related to nilotinib and the use of other tyrosine kinase inhibitors for the treatment of neurodegenerative diseases.)

One reason may be that DDRs are protein enzymes known as tyrosine kinases that act as on and off switches of the cell self - cleaning process known as autophagy.

Dr. Yaffe's research focuses on the biology of the complex signaling pathways that cells use to respond to DNA damage and inflammation, particularly the role of protein kinases and modular binding domains in tumor development and anti-cancer therapeutics.

In the first test using KnIT, the team sought to identify new protein kinases that phosphorylate (or turn on) the protein tumor suppressor p53.

When calcium floods a neuron as a memory is formed, it turns on an enzyme called CaMKII (calcium / calmodulin - dependent protein kinase).

In experiments on baker's yeast, Harbauer discovered that a cyclin - dependent kinase phosphorylates a mitochondrial protein at the beginning of mitosis, meaning that the kinase modifies the protein to activate it.

To help on this front, in a new paper published in the journal Structure, researchers from McGill University present in atomic detail how specific bacterial enzymes, known as kinases, confer resistance to macrolide antibiotics, a widely used class of antibiotics and an alternative medication for patients with penicillin allergies.

While more than 30 kinase inhibitors have been approved for the treatment of disease, the kinome has been largely unexplored until SGC - UNC, DiscoverX and other SGC partner companies embarked on this project.

It's been an important question — many lung cancers depend on over-activation of the gene EGFR, but then when EGFR inhibitors like gefitinib or erlotinib are used, the cancers tend to activate other «kinases» that allow the cancer to by - pass around this dependence.

After our extensive analyses on protein kinases, the protein phosphatases were naturally to follow.

Hund's team identified a phosphorylation site (Serine 571) on the voltage-gated sodium channel targeted by CaM kinase II that serves as a switch for inappropriate «late» sodium influx.

In normal intact cells, activation of protein kinase C (PKC) by phorbol ester either stimulated or inhibited chloride secretion, depending on the physiological status of the cell.

Unlike with protein kinases, the current knowledge of protein phosphatase functions and especially on their formed interactions and complexes remains fragmentary.

Aurora kinase has many subtypes, but is generally known for its role in cell division — an additional link between regeneration and division that helped to confirm Lin was on to something.

In 1995, I began graduate studies on signal transduction by growth factors and receptor tyrosine kinases in the laboratory of Graeme Guy at the Institute of Molecular and Cell Biology (IMCB) in Singapore, obtaining my PhD in 2000.

The researchers, including scientists from pharmaceutical company AstraZeneca, report in an advanced online publication in Nature Medicine on May 4, that their findings indicate «an underappreciated genomic heterogeneity» in mechanisms of resistance to tyrosine kinase inhibitor (TKI) drugs that target the Epidermal Growth Factor Receptor (EGFR) mutation that drive some cases of non-small cell lung cancer (NSCLC).

Focusing on a particular group of enzyme - blocking compounds called protein kinase inhibitors, they identified 31 compounds that inhibit malaria growth without harming the host.

«The LINK - A dependent HIF1 signalizing cascade and the consequent effects on cancer cells implicate LINK - A and LINK - A interacting kinases and receptors as promising therapeutic targets for TNBC.»

«Our hope is that, based on the structural data presented in our paper, it may be possible to develop drugs that inhibit cancer progression by blocking the interaction of focal adhesion kinase with other proteins,» says Dr. Meves.

Special focus is placed on Rho - kinase inhibition, relating to its potential to promote and support extracellular matrix production in cultured chondrocytes and its role in fibroblast cells as a part of direct chemical cellular differentiation.

It built on previous ground - breaking work on malaria published in 2011 by author Monash Professor Christian Doerig, and others, who found that if host cell protein kinases were prevented from working it would kill malaria parasites.

For the new study, the research team focused on activating an enzyme known as AMP - activated protein kinase, or AMPK, which — among other roles — stimulates the breakdown of glucose for energy.

We also noted constitutive surface expression of the tyrosine kinase receptors Tie - 2, FGFR - 1, and Flk - 1 on proliferating and resting endothelial cells (data not shown).

The study, published in Nature Communications today, focused on protein kinases, enzymes that are key regulators of cellular processes.

This thesis primarily investigates the effects of mechanical cyclic stretching, a 5 % low oxygen atmosphere and the Rho - kinase inhibitor, Y - 27632, on protein responses in chondrocytic human chondrosarcoma (HCS - 2 / 8) cells.

However, despite extensive research on TOR over the last decades, attempts to uncover the detailed structure of the protein kinase and its partners have been unsuccessful.

A randoMized phAse II trIal of fulvestraNt wiTh or without Ribociclib After progression on AntI-estrogeN therapy plus cyclin - dependent kinase 4/6 inhibition in patients with unresectable or metastatic hormone receptor positive, HER2 negative breast cancer (MAINTAIN Trial)

The activity of tyrosine kinases is typically regulated in an auto - inhibitory fashion, but the BCR - Abl fusion gene codes for a protein that is «always on» or continuously activated leading to unregulated cell division (i.e. cancer).