Sentences with phrase «on mechanisms of disease»

Skin biopsies are then collected and reprogrammed into induced pluripotent stem (iPS) cells by the NYSCF Global Stem Cell Array, permitting Dr. Fossati and her team to generate patient specific neural cells, which will hopefully shed light on the mechanisms of disease progression.

Not exact matches

As pharmacologists, our interest is primarily in the mechanisms and therapeutics of ischemic heart diseases, and we have been working on the cardiovascular effects of herbs according to modern scientific criteria.

The work was on the role of interleukin - 1 in the pathology of graft - versus - host disease (GVHD), the mechanism by which the new immune system, which a patient receives as a bone marrow transplant, attacks the patient's body following the transplantation.

Right now the research team is teasing out further details of the disease mechanism since this will steer researchers on a path towards much - needed treatment for motor neuron diseases.

Scientist at the University of Copenhagen and Skejby Hospital will continue their work on how bacteria might affect the balance between the immune defence mechanism and the disease.

Tuncay Baubec, professor at the Department of Molecular Mechanisms of Disease at the University of Zurich, and his team have shown that one particular protein plays an important part in this process: The DNA methyltransferase 3A (DNMT3A) enzyme is responsible for positioning the methylation to the right place on the DNA.

More recently, I have worked on the role of dispersal and disease as mechanisms that help support and maintain ecological diversity.

Disease - driving mechanisms vary and include, among others, the pruning of neuronal synapses, effects on CNS development in utero, and inflammation.

However, many industry insiders say these changes are opening up unique opportunities for researchers who focus on translating basic science into real - world cures and are eager to explore the molecular mechanisms of disease, test hypotheses, and do work that benefits patients.

Therefore, this group's research method and the idea of pathological mechanisms involving RNA abnormalities will be applied to pathological research on various diseases.

«We see that two completely different disease entities share a common pathogenic mechanism,» said George Hajishengallis, a professor of microbiology in Penn's School of Dental Medicine and an author on the study.

Instead of addiction being a chronic, permanent disease, recent evidence is showing that addiction is controlled by molecular switching mechanisms in the brain, that can be turned on or off with the right interventions» says Dr. Steven Laviolette.

The suite of new findings provides a critical window on the mechanism for CJD and similar triplet repeat diseases like Huntington's.

Dr. Agarwal is currently interested in the mechanisms and therapy of genetic blood diseases, with a focus on dyskeratosis congenita.

Exposure to a group of common pesticides, called dithiocarbamates, has long been associated with an increased risk of Parkinson's disease, although the mechanism by which the compounds exert their toxicity on the brain has not been completely understood.

The study is investigator led and has therefore focused on clinical need, targeting patients with progressive multiple sclerosis in whom most disability is incurred... The study also reports a predominant effect on neurodegenerative rather than inflammatory outcomes, suggesting a novel mechanism of action that might be suitable as combination treatment with immunomodulatory treatments... Further phase 3 studies to measure the effect of simvastatin on sustained disability, particularly in patients with non-relapsing secondary progressive and primary progressive multiple sclerosis, are clearly needed, but this trial represents a promising point from which to develop trials of progressive disease.»

Erlich and his team, which included researchers from Harvard, MIT, Stanford University, and Mount Sinai, plan next to study the effect of these eSTRs on more human diseases and better understand their molecular mechanism.

On the other hand, the mere brain amyloidosis in Alzheimer's disease involves several mechanisms and it is unlikely that a single cocktail of nutrients will provide an optimal outcome.

Based on recent information on the mechanisms of chemotherapy, a team of researchers of the McGill University Health Centre (MUHC) developed a new clinical approach to increase the efficiency of treatment in glioblastomas that increased the median survival to 22 months — bringing much needed hope to those affected by this aggressive disease.

Dr. Nemer is a distinguished medical researcher whose focus has been on the heart, particularly on the mechanisms of heart failure and congenital heart diseases.

Dr Alexander Mazein, lead author of the study from the European Institute for Systems Biology and Medicine, commented: «In - depth understanding of asthma means redefinition of asthma subtypes based on the mechanisms that lead to the development of the disease.

One of the reasons for this is the lack of knowledge on the cellular mechanisms which cause alterations in nerve transmissions and the loss of memory in the initial stages of the disease.

«More studies are required in order to make these important associations in terms of the effects of supplementation on cardiometabolic syndrome, the immune and inflammatory mechanisms of cardiovascular disease in postmenopausal women, and their quality of life,» Nahas said.

«Knowing this mechanism that underlies IL - 37's effect on the immune system now allows us to study IL - 37 function and perhaps dysfunction in a wide range of diseases,» says Mayumi Fujita, MD, PhD, investigator at the University of Colorado Cancer Center, associate professor in the CU School of Medicine Department of Dermatology, and the paper's senior author.

Students in the UBC program engage in a wide range of research: molecular mechanisms underlying cell proliferation in cancer or cell death in stroke; relating gene mutations to disease mechanisms; the social factors that determine access to health care for women living on the street.

Toxins from mold found growing on nuts or corn can weaken the airways» self - clearing mechanisms and immunity, opening the door for respiratory diseases and exacerbating existing ones, suggests a study in Nature Scientific Reports published this month from otolaryngology researchers at the Perelman School of Medicine at the University of Pennsylvania.

Dr Daniel Martin, Senior Lecturer and Honorary Consultant, UCL Division of Surgery and Interventional Science and Director of UCL CASE Medicine, adds: «These exciting results give us a unique insight into the possible mechanism of insulin resistance in diabetes and provide some clues as to where we should be thinking about focusing further research on novel treatments for this disease.

here is epidemiological evidence that links type B coxsackie virus (CVB) infection with heart disease, and research published on July 31st in PLOS Pathogens now suggests a mechanism by which early infection impairs the heart's ability to tolerate stress at later stages of life.

The findings, published in the journal ACS Central Science, shed new light on the underlying mechanisms of CF and could lead to improved prognosis and better therapies for a disease which is quite variable, affecting different children in different ways, say researchers.

He notes that these findings «fill in gaps» in our understanding of the mechanisms that cause breast cancer and may encourage some researchers to rethink their position on viruses as a trigger of the disease.

Our focus has always been on the core discipline of biochemistry and how it helps us understand organic life and the fundamental mechanisms that underlie human disease.

In this review topic, researchers looked at novel translational noise studies demonstrating the molecular mechanisms that may lead to impaired vascular function, recent epidemiologic evidence of noise - induced cardiovascular disease, and the non-auditory effects of noise and their impact on the cardiovascular system.

Identifying the molecular causes of disease represented a major breakthrough in the history of medicine, moving the discipline from pattern recognition and therapeutic strategies based on syndromic pathophysiology to molecular mechanism and evidence ‐ based therapies derived from clinical trials designed on the basis of molecular mechanism.

Noise may disrupt the body on the cellular level in a way that increases the risk of common heart disease risk factors, according to a review topic published today in the Journal of the American College of Cardiology that examined the underlying mechanisms that may lead to noise - induced heart disease.

The CPC maintains a focus on experimental pneumology with the investigation of cellular, molecular and immunological mechanisms involved in lung diseases.

The strategy of drug discovery may correct defects associated with genetic diseases as it continued to I - Stem is based on the access that pluripotent stem cells provide molecular mechanisms involved in these diseases.

Additional limitations to the traditional approach include: costly failures to replicate positive results in larger trials; difficulty in determining the reasons for negative results; low yield in terms of identifying disease or intervention mechanisms due to an exclusive focus on symptom change and clinical endpoints; and, the expensive and very lengthy practice of first establishing multi-component psychosocial treatments followed by years of «unpacking» studies.

What's more — in the absence of information on the underlying molecular mechanisms of her particular case — that patient will likely end up taking a one - size - fits - all pill rather than a drug tailored for her unique disease subtype.

Research focus My research is focused on understanding detailed mechanisms of complex diseases, including Inflammatory Bowel Disease, with the ultimate goal of finding an appropriate treatment for patients.

Isaiah Mansour, an undergraduate at the University of Maine, talks about how a Maine INBRE course on the molecular mechanisms of human disease at the MDI Biological Laboratory changed his life.

In particular, the savvy scientists at the renowned Buck Institute for Research on Aging are devoted to geroscience, studying the mechanisms of aging and the connection between normal aging and chronic disease, in the institute's Novato labs.

Matthews» laboratory research, with long - term support from the National Institutes of Health, focuses on the fundamental mechanisms used by epithelial tissues to regulate salt secretion — which goes awry in several diseases, including cystic fibrosis and many forms of diarrhea.

Fuentes» doctoral work focuses on sex - specific mechanisms of inflammation in asthma and allergic diseases.

Typically, evidence that disease activity is truly «on - target» with respect to the proposed mechanism can only be examined once appropriate, highly selective chemical tools have been designed, synthesized and iteratively modified by teams of Medicinal Chemists and biologists working with the studied protein.

Confocal microscopy of convertases and known disease - related human convertase mutants in cells and tissues will also be used to shed light on subcellular targeting mechanisms.

Researchers from the group of Gary L. Dunbar at Central Michigan University, Michigan, USA have recently shown the ability of adenovirally generated rat iPSCs to survive and differentiate in the striatum of rats [6], and now in a study in Stem Cells Translational Medicine, they focus on the efficacy of transplantation of these cells into the 3 - nitropropionic acid (3 - NP) rat model of HD [7], which induces cell death by energy - depleting mechanisms providing an accurate model of cell loss and replicates many features of the disease [8].

The institute is expected to focus on nervous systems and brain problems, specifically neurodegenerative diseases, sleep disorders, mechanisms of brain repair, and behavioral disorders.

Dr. Torkamani's research covers a broad range of areas centered on the use of genomic technologies to identify the genetic etiology and underlying mechanisms of human disease in order to define precision therapies for diseased individuals.

The collaborative work by Merck and Emulate researchers enabled new functionality for the Small Airway Lung - Chip to demonstrate the mechanism of action for therapeutic compounds acting on inflammatory disease states in the small airway, particularly in diseases such as asthma.

Research activities are also concentrated on the identification of disease mechanisms in vertebrates with the ultimate goal to identify molecular targets and cells with therapeutical potential.