LDN is an anti-inflammatory agent in the central nervous system, via action
on microglial cells.
Not exact matches
Eggen and his collaborators investigated the impact of high - and low - fat diets
on inflammation and
microglial markers in a specific brain region — the hypothalamus — of 6 - month - old mice.
Building
on the evidence that microglia were in play during injury, the researchers conducted tests in zebrafish with the specialized enzyme incorporated into both rod cells and
microglial cells, removing both cell types to ask what role microglia play during regeneration.
In both groups of mice, the expected deleterious effects
on memory and learning didn't arise if EP2 within
microglial cells was absent, as a result of a genetic manipulation.
Building
on her work in characterizing
microglial subpopulations, she proposes to decipher the precise anatomical location and proximity of microglia most likely to drive neurodegeneration and synapse loss.
But
on the other,
microglial inflammatory mediators modulate immune cells, act
on neurons, and have been shown to contribute to neurodegenerative effects.
«Activation of
microglial cells is,
on one hand, beneficial for neuronal tissue, as it stimulates clearance of cell debris and prompts secretion of several neurotrophic factors.