Sentences with phrase «on microtubule»

We are particularly interested in uncovering the effects of chronic ethanol exposure and abstinence on the extracellular matrix, on the microtubule cytoskeleton and on the proteome of excitatory synapses.

«The take - home message is that this is the first time we've seen how this protein sits on the microtubule, and this is going to be of major importance down the road,» Wilson - Kubalek added.

«Our study on the TACC3 - chTOG interaction will allow cellular biologists and researchers on microtubule dynamics to better understand how microtubule assembly is regulated during cellular division,» says Montoya, and he anticipates that «it could also help in developing new anti-microtubule drugs, providing more effective therapeutic options in cancer treatment.»

Bandyopadhyay's 2013 work on the microtubule required refitting a special microscope and contracting with an outside firm to create a needle with a 1 - by -1-nanometer point — the smallest ever constructed, Bandyopadhyay says.

Fostamatinib's effect on microtubules seems to increase the stabilizing effect of paclitaxel, even in resistant cells, which in turn may prevent cancer cells from proliferating, says Yu Yu, Ph.D., a postdoctoral fellow at the Johns Hopkins University School of Medicine and co-author of the study.

«You know,» says Hameroff, stopping him, «you ought to do some research on microtubules.»

His work on microtubules, prior even to ever getting involved with Penrose, is brilliant, and it is the reason I work on microtubules today.»

Tuszynski's lab published a paper last summer on the conductive properties of microtubules in Nature Scientific Reports, and it is preparing a paper on microtubules as memristors.

The IBMC researchers (Porto University, Portugal) reveal that the existence of specific signals on microtubules — which work as intracellular highways — give directions to chromosomes of which route to take in the course of cell division.

Organophosphates can affect a variety of proteins and pathways in cells, and the impacts on microtubules and microtubule - related proteins are likely to be many.

Protein friction limits diffusive and directed movements of kinesin motors on microtubules.

Not exact matches

Fission yeast (Schizosaccharomyces pombe) cells grow longitudinally in a manner dependent on a polarized distribution of their interphase microtubules.

Stuart Hameroff, an anesthesiologist who has spent many years studying brain functions, has collaborated with renowned Oxford University polymath Roger Penrose on a model that explains consciousness as the result of quantum processes occurring in tiny structures called microtubules in brain cells.

The axoneme's movement is accomplished via rows of motor proteins called dyneins that are attached along the microtubules and exert force on them so the microtubules «slide» past each other, which then causes the entire axoneme and sperm tail to bend and move.

The protein assembly line consists of microtubules that serve as train tracks on which the raw materials — including messenger RNA (mRNA)-- are carried to the protein - making machinery, called ribosomes.

Which of these becomes dominant depends on the relative concentrations of the tubulins and the motor proteins: In a certain concentration range the dynamic equilibrium between growth and shrinkage of the microtubules operates as it would if resources were not limiting.

Building from two subunits, alpha and beta tubulin, this protein assembles into microtubules that play a vital role inside cells — giving structure, pushing or pulling other things around, or providing a track on which other molecules can pull themselves along.

Microtubules not only confer mechanical stability on cells and help to dictate their forms, they also serve as an intracellular transport network.

In earlier work, Frey's group had shown that the density of molecular motors attached to the filaments has an impact on whether the microtubule grows or shrinks, and that their effect depends on the length of the filament concerned.

Microtubules even come into play on the outside of cells, forming into cilia and flagella that allow for cell movement.

Dr. Stuart Hameroff, lead author on the new TUS study, said: «This suggests TUS may stimulate natural megahertz resonances in brain microtubules, enhancing not only mood and conscious mental states, but perhaps also microtubule functions in synaptic plasticity, nerve growth and repair.

«Sensitive teeth are caused by the movement of fluid in tiny holes in dentine called microtubules, which puts pressure on the nerve below,» says Nigel Hughes, one of the researchers at Unilever.

Orch - OR, on the other hand, suggests that consciousness originates from quantum interactions in the microtubules inside each cell.

The researchers chose to focus on the cell - division machinery, studying the meiotic spindle, the structure composed of microtubules that attaches to chromosomes, pulling them to opposite sides of a cell before it divides.

Early on in his career, Hameroff suspected microtubules might provide an answer.

The study, published on October 6 in Cell, describes how two proteins work together to guide the growth of a new microtubule along an existing one.

It has been found that the establishment and maintenance of polarity is governed by the interdependent relationship between the polarity marker protein on the plasma membrane (cell membrane), actin, the microtubule cytoskeleton, and membrane vesicle transport.

To get a more intuitive handle on his own research, Odde is using human dancers to explore how the cell's skeleton of microtubules spontaneously assembles and falls apart.

«Our results indicate that TACC3's function completely depends on this interaction, so that mutations in the latter prevent chTOG from correctly incorporating into the microtubules,» states Montoya.

The research group working at IBMC focused on the exact moment of cell division, when cells assemble a new microtubule network, which is then arranged as a very well - known structure: the mitotic spindle.

By shining a laser light on a microscopic - sized plastic bead attached to a pair of microtubules linked by kinesin - 5 molecules, the team tracked their activity and discovered that this force is a function of the microtubule overlap — the longer the overlap, the greater the force.

The mitotic spindle is composed of thread - like proteins, called microtubules, which extend from one of two spindle poles on either side of the cell to the duplicated chromosomes in the cell's center.

The tip - tracking TOG - TACC machinery acts as a catalyst of microtubule assembly, and it turns out, based on the new results, that TOG - TACC is a very unusual type of catalyst that stabilises its product (the microtubule railway) as well as speeding up its growth.

«These «fastener» proteins do not consume energy, yet they somehow maintain their positions on the filaments, known as microtubules, in spite of all the activity going on,» says Scott Forth, a postdoc in the lab who led the research.

Professor Cross said: «It has been known for some time that a team of proteins called TOGs sits on the tip of the growing microtubule track and works like a team of tiny railway workers to rapidly lay the new microtubule track.

Kiyomitsu's latest work focuses on the next step of mitosis, called anaphase, when the microtubules tear the paired chromosomes apart so that one copy of each chromosome ends up in each of the new daughter cells.

His group's paper in the Journal of Physics A: Mathematical and Theoretical describes a new theoretical approach to study the effect of intermolecular interactions on the dynamics of motor proteins that move along cytoskeletal filaments known as microtubules.

By revealing how microtubule growth is catalysed, the WMS team expect their work to throw new light on the workings of a number of human diseases (for example, bowel cancer) linked to abnormalities in TOG - TACC function.

«Motors that move along microtubule tracks like cars on a highway do a lot of work in cells.

«The important thing we realized is that the microtubule's dynamics — how and when it approaches a stationary state — could depend on initial conditions,» Kolomeisky said.

In research detailed last week in Cell, the Rockefeller team discovered some of these fastener proteins, known as non-motor microtubule associated proteins, or MAPs, experience different degrees of friction depending on the direction in which they are being moved along a microtubule.

«Knowing how much force the microtubules and spindle exert on the kinetochore is very important because it's like a bridge,» Maresca says.

Before dividing, pairs of identical chromosomes line up in the middle of the elongated cell, and the microtubules, emanating out from the centrioles on either side, help pull the chromosomes in opposite directions so that each new cell receives one member of each chromosome pair.

We demonstrated the technique on 20 different biological processes spanning four orders of magnitude in space and time, including the binding kinetics of single Sox2 transcription factor molecules, 3D superresolution photoactivated localization microscopy of nuclear lamins, dynamic organelle rearrangements and 3D tracking of microtubule plus ends during mitosis, neutrophil motility in a collagen mesh, and subcellular protein localization and dynamics during embryogenesis in Caenorhabditis elegans and Drosophila melanogaster.

A group of plant biologists at the Institute of Transformative Bio-Molecules (ITbM) of Nagoya University, the University of Tokyo, the Gregor Mendel Institute, and the University of Kentucky, has reported in the journal Proceedings of the National Academy of Sciences, on their discovery on how the plant's egg cells initially lose their skeletal pattern upon fertilization and are reorganized by two major cytoskeleton components in the cell, microtubules (MTs) and actin filaments (F - actin).

Inside cells there are tiny motor engines that ride on thin rods called microtubules.

The evening began with Hancock, accompanying himself on the ukulele, singing «I wish they all could be microtubules» to the tune of the Beach Boys» «I wish they all could be California girls.»

Johanna Roostalu is a Sir Henry Wellcome Postdoctoral Fellow at the Cancer Research UK London Research Institute where she is working on a project to elucidate the molecular mechanism of spindle assembly and microtubule self - organization using a combination protein biochemistry, fluorescence microscopy, microfluidics and mathematical modeling.

Aside of the inhibition of signal transduction, on - target repositioning assumes that the targets recognized in nematods, such as mitochondrial respiration and microtubules, are hit in cancer cells [70, 89, 90].

Isoform - dependent effects of apoE on doublecortin - positive cells and microtubule - associated protein 2 immunoreactivity following 137 Cs irradiation.