Sentences with phrase «on models of human disease»

Not exact matches

The Dr Hadwen Trust for Humane Research claims that «in some instances, reliance on inaccurate animal «models» of human disease have undoubtedly delayed medical progress.»

With our human gut - on - a-chip, we can not only culture the normal gut microbiome for extended times, but we can also analyze contributions of pathogens, immune cells, and vascular and lymphatic endothelium, as well as model specific diseases to understand complex pathophysiological responses of the intestinal tract.»

These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed «patient in a dish»); «body on a chip» devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy.

This discovery will solve one of the key stumbling blocks in devising therapies: the lack of a human model that can shed light on how the disease progresses.

In order to test their hypothesis in a model that more closely mimicked human disease, the researchers also tested the two drugs side - by - side on slices of tumors removed from patients during radical prostatectomy.

Mardinoglu says the team's network modeling approach, which relied on data from the Sweden - based Human Protein Atlas project and The Genotype - Tissue Expression (GTEx) project consortia, can be used in the identification of drug targets and eventually in the development of efficient strategies for treating a number of chronic liver diseases.

«If human organs on chips can be shown to be robust and consistently recapitulate complex human organ physiology and disease phenotypes in unrelated laboratories around the world, as suggested by early proof - of - concept studies, then we will see them progressively replace one animal model at a time.

His research focuses on the cancer biology, drug resistance, and signaling pathway networks of human diseases as well as on ways to model these disorders.

Such ease of use will likely encourage the use of more animal models in the study of human diseases, says Rhonda Wiler, a geneticist at biotech giant Genentech in San Francisco, California, who co-chairs the Roundtable on Science and Welfare in Laboratory Animal Use (which organized the workshop).

«In the future, such efforts could allow us to much better understand human - microbiome interactions, model malnutrition disorders and inflammatory diseases of the gut, and perform personalized drug testing,» said co-first author Alessio Tovaglieri, a Graduate Student at the Department of Health Science and Technology at ETH Zurich in Switzerland, who performs his thesis work on Ingber's team.

The new study is based on the development of mouse models manifesting the disease that causes megalencephaly, spasticity and ataxia in humans.

Thank you for airing Joseph Garner's views on the futility of trying to cure mouse «models» of human diseases (29...

To determine the effect of gastric acid suppression on the progression of chronic liver disease, Schnabl's team looked at mouse models that mimic alcoholic liver disease, NAFLD and NASH in humans.

Thomas W Geisber, an expert on Ebola and siRNAs at The University of Texas Medical Branch, said the research was «highly significant because it shows protection against Ebola in a robust model of human disease: non-human primates.»

«What we've shown in the monkey model matches a lot of what people have observed in epidemiological studies of humans,» says Emma Mohr, a pediatric infectious disease fellow at UW — Madison and first author on the study with Matthew Aliota and Dawn Dudley, research scientists in UW — Madison's schools of Veterinary Medicine and Medicine and Public Health, respectively.

Although further refinement and testing is needed, Dr. Burgess said the new techniques have the potential to speed the production of many different types of transgenic animal models that will shed new light on human development and disease.

«Amy's video is both beautiful to watch on an aesthetic level and beautiful to watch as an illustration of how simple model organisms like Ashbya can give us insights into human diseases like Alzheimer's,» Atkinson continues.

Together, our results suggest a comprehensive model of chromatin dynamics during development and set the foundation for similar work on human blood formation and disease.

PHENOMIN's involvement in the IMPC will fulfill a key item of the the National Alliance for life sciences and health (AVIESAN) strategic plan that consists in applying mouse genetics to analyze the mechanisms of disease and to use this knowledge for advancing fundamental research and human health (AVIESAN report on the use and needs of mouse models in the French scientific community, 2010).

In recent years, researchers have developed so - called «senolytic» drugs that wipe out senescent cells in aging mice and mouse models of age - related disease, exploiting the high dependence of these cells on specific biochemical survival pathways.9, 10 In these studies, senolytic drugs have restored exercise capacity9 and formation of new blood and immune precursor cells11 in aging mice to near youthful norms, and prevented or treated mouse models of diseases of aging like osteoarthritis, 12 fibrotic lung disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with human clinical trials expected to begin in 2019.

We focus on developing computational methods and tools for (a) analyzing large - scale gene expression data related to human cancer in search for gene markers and disease sub-categories, (b) identifying regulatory elements such as miRNA precursors and their targets in whole genomes of plants and mammals, (c) building theoretical models of gene regulatory networks.

Over the last few years, scientists have been able to recreate accurate models of human organs by embedding living tissue onto chips, allowing them to study the effects of drugs and diseases without testing on animals or humans.

It should be noted, however, that while a study on senescent cell ablation in genetically normal mice would provide at least some evidence on the effect of senescent cells (and their ablation) on promoting cancer, even such a study would likely show less effect than could be anticipated in a large mammal model, since even normally - aging mice rarely suffer metastatic disease to the extent of aging humans, as sheer primary tumor volume is generally sufficient to be fatal to mice.

Moreover, PHENONIM - ICS is involved in European projects presenting a strong impact on human health: Interreg CARDIOGENE (Genetic mechanisms of cardiovascular diseases), GENCODYS (Genetic and epigenetic networks involved in cognitive dysfunctions), AgedBrainSYSBIO (Basic studies of brain aging), as well as projects in partnership with industry: MAGenTA (an Industrial Strategic Innovation project supported by Bpifrance about the treatment of major urogenital diseases) and CanPathPro (H2020 program), to develop a predictive modeling platform of signaling pathways involved in cancers.

The HTS at I - Stem focuses on relevant biological models of genetic diseases: the human stem cells and their progenies.

«Historically, we have had trouble modeling human diseases caused by mutation of just one copy of a gene in mice, which impedes research on complex conditions and limits our discovery of therapeutics,» explained Srivastava, director of the Gladstone Institute of Cardiovascular Disease and senior author on the study.

In addition, projects to perform genetic interaction screens on disease genes in model organisms (yeast, worm, fly, fish) will not be considered, unless the project includes substantive specific aims that investigate the disease relevance of any new genes discovered in human or mammalian model systems.

These experiments are innovative because they seek to improve a mouse model based on current knowledge from human disease, while also testing novel therapies that could be of benefit for affected individuals.

WFSM establishes laboratory to develop transgenic and knockout mice to model human disease and shed light on function of human genes.

His research focuses on understanding the role of genetic variation in contributing to human health and disease using mouse models of human disease, and more recently exploiting technologies developed for biomedical research for application in the field of genetic pest management.

The Ellerby lab is known for its pioneering studies on Huntington's disease (HD), and Karen is now using human stem cell models of HD to understand why important molecular signaling pathways, such as the TGF - β pathway, are dysregulated in HD.

These mouse models could shed light on a wide range of human diseases such as diabetes, many types of cancers, and even neurological diseases such as depression.

I am currently working on a variety of NIH - funded projects, including areas such as bioinformatics research portals, visualization for review of chart records, and tools for aiding the discovery of animal models of human diseases.

For three years now we have been working on human cell models of rare neurodegenerative diseases with special emphasis on neuroacanthocytosis, neuronal ceroid lipofuscinosis as well as motor neuron degeneration (using iPS cells).

Numerous mouse models have been generated to examine the pathogenesis of the disease and to evaluate therapeutic approaches, but the most precise genetic reproductions of the human condition are the knock - in (KI) mouse models which express the huntingtin mutation in the proper genetic and protein context on the murine gene.

The work in humans is complemented by laboratory work involving cell death in Parkinson's disease, effects of stimulation on hippocampal neurogenesis and animal models of deep brain stimulation.

«Given the long and established history of curcumin as a spice and herbal medicine, its demonstrated chemopreventive and therapeutic potential, and its pharmacological safety in model system, curcumin, the bioactive extract of curcumin, promises a great future in human clinical studies designed to prevent and / or delay age - related diseases,» explained the authors of a review on these and other animal studies involving curcumin.

The Effect of Acetyl - L - carnitine and R - alpha - lipoic acid Treatment in ApoE4 Mouse as a Model of Human Alzheimer's Disease J Neurol Sci 2009 (Mar 31)[Epub ahead of print] We measured age - dependent effects of human ApoE4 on cerebral blood flow (CBF) using ApoE4 transgenic mice compared to age - matched wild - type (WT) mice by use of -LSB-(14) C] iodoantipyrene autoradiogrHuman Alzheimer's Disease J Neurol Sci 2009 (Mar 31)[Epub ahead of print] We measured age - dependent effects of human ApoE4 on cerebral blood flow (CBF) using ApoE4 transgenic mice compared to age - matched wild - type (WT) mice by use of -LSB-(14) C] iodoantipyrene autoradiogrhuman ApoE4 on cerebral blood flow (CBF) using ApoE4 transgenic mice compared to age - matched wild - type (WT) mice by use of -LSB-(14) C] iodoantipyrene autoradiography.

Her address, «A New Medical Research Model: Advancing Human and Animal Health Humanely,» will detail the concept of a new research model predicated on a meaningful commitment by both medical and veterinary researchers to work cooperatively together to address disease and disorders in humans and animals — evaluating genetic and environmental risk factors, sensitive diagnostic indicators and novel theraModel: Advancing Human and Animal Health Humanely,» will detail the concept of a new research model predicated on a meaningful commitment by both medical and veterinary researchers to work cooperatively together to address disease and disorders in humans and animals — evaluating genetic and environmental risk factors, sensitive diagnostic indicators and novel theramodel predicated on a meaningful commitment by both medical and veterinary researchers to work cooperatively together to address disease and disorders in humans and animals — evaluating genetic and environmental risk factors, sensitive diagnostic indicators and novel therapies.

Oral administration of Lactobacillus microbes has been demonstrated to have beneficial therapeutic effect in experimental models of neurological disease, as well as in recent clinical trials on depression and anxiety disorders in humans.

The emphasis is on developing intellectual abilities and research skills through investigations of infectious diseases of food - producing, companion, and aquatic animals, as well as animal models for human disease.

Dr. Dodds has been a member of many national and international committees on hematology, animal models of human disease, veterinary medicine and laboratory animal research.

Dr. Dodds has been a member of many committees on hematology, animal models of human disease and veterinary medicine.

Current models of climate change include sea level rise, land degradation, regional changes in temperature and precipitation patterns, and some consequences for agriculture, but without modeling the feedbacks that these significant impacts would have on the Human System, such as geographic and economic displacement, forced migration, destruction of infrastructure, increased economic inequality, nutritional sustenance, fertility, mortality, conflicts, and spread of diseases or other human health consequences [135,Human System, such as geographic and economic displacement, forced migration, destruction of infrastructure, increased economic inequality, nutritional sustenance, fertility, mortality, conflicts, and spread of diseases or other human health consequences [135,human health consequences [135,136].

It concentrates on repairing damage within a disease model of human functioning.