Sentences with phrase «on necessary developments»

Based on these promising results, work has begun on the necessary developments to propose to patients suffering from Friedreich's ataxia and presenting a progressive cardiomyopathy a treatment by gene therapy.

They have come to important conclusions, both on the conduct of Monsanto and on necessary developments in... more

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

Entrepreneurs who possess this valuable knowledge can prioritize better, make more efficient architecture decisions, and intelligently push back on development projects that aren't necessary.

Brent Taylor, Beyond Meat's VP of Corporate Development believes the firm's ability to focus on its core competencies has enabled it to grow rapidly without getting bogged down in such necessary time sucks as payroll, benefits and vacation time.

As Metzger points out, the most easily and thoroughly automated industries on Earth today are also those most necessary for space development — the manufacturing of electronics, transportation equipment, and machinery.

Depending on the element in question, the need for new development is needed to keep prices under control, or even necessary to prevent shortages.

The Parity client's development team seems to be adding the necessary code changes this week on Github.

With the growing amount of crypto - currencies and the diminishing domination of Bitcoin in the market, an index became necessary to track its development on the exchanges like the S&P 500 does the same for the US stock market.

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

To affirm that in this way a necessary, unavoidable, historical process of development on a large scale in the doctrines which are not defined dogma is legitimate and a matter of course, is not to say that this history does not also contain mistakes, over-hasty (though only provisional and revocable) decisions, cases of short - sightedness and lack of understanding.

Thus did Newman's view of development pose one final, necessary challenge: the need to take seriously the institutional Church, a notion alien to my evangelical world, where a «high» view of the Church typically meant little more than attending morning and evening services on a Sunday.

It is also necessary to insist that any pattern of development for the tribals and others who still have cultures and communities predominantly based on the primal vision of undifferentiated unity, world - as - nature and cosmic spirituality, should introduce differentiation and individuality, historical dynamism and secularism gradually and without violently tearing down but grafting on to the stabilities of traditional spirit and patterns of life and living followed by them In fact from my experience, I have found that modernized educated tribal leaders are the worst offenders in this respect.

i) «It is necessary to break down the barriers of monopolies which leave so many countries on the margin of development, and to provide all individuals and nations with the basic conditions which will enable them to share in development.

Hence, on this issue, I see no objection to viewing DNA as a type of machine.1 Furthermore some machines can self - replicate if given the right instructions and materials, they are counterentropic, and they can determine necessary conditions for the development of other machines.

Still, plans are under way for creating the necessary vehicles and artificial environments for space travel and residence, vast resources of intelligence and materials are being expended on research and development in the field of space technology, and increasing numbers of able young people are being educated for future work in this field.

The first part of the theory states that religious pluralism and societal complexity are inversely related, the reasoning being that while religious pluralism is itself a kind of complexity, it has an inhibiting influence on those «secular» interactions necessary for the kind of development I have called societal complexity.

Remember if you aren't at the head of the class when it comes to the development of young talent, which means eyes on the ground everywhere, a vast array of connections with soccer associations throughout Europe and beyond and a manager willing to properly train and play said blue chippers, (like the 90s Arsenal or clubs like the modern day Monaco and Dortmund) you need to spend to win... anything in between is highly problematic... failure to make the necessary changes leaves you in the proverbial «no man's land» and that is currently where we reside... it's difficult to get out of this rut... just ask either of the Milan teams... next step after that is being known as a «seller», which could be us already if and when Sanchez leaves... there are only two teams that have worn this moniker in recent times and had some decent success and that is Athletico Madrid and Dortmond, which only occurred when they both brought in new, charismatic leaders in Simmone & Klopp... the odds that Wenger could conjure up the magic to repeat the performances of a bygone era are incredibly low, so why prolong the agony... he's not willing to create the hierarchy necessary to go the youth route and he's unwilling to put his team's potential success ahead of his job security by laying it on the line with Moustache, so it's time to place all your chips in the middle or go gently into that good night

Being overly focused on content often excludes the necessary development of socio - emotional skills.

The development of computerized neurocognitive tests such as ImPACT have been a big advance in terms of making sure an athlete has recovered their cognitive function necessary to return to play or work, but the usual and primary treatment remains rest, with follow - up testing using the ImPACT paradigm, and return to play or work following the algorithm of the ImPACT program based on test results.

I gave a talk at the Summit which laid out ten reasons, based on adolescent development, for why a revolution is necessary to bring a greater and more sophisticated investment in teens themselves, and in the environments they move in.

His or her sense of entitlement is actually a normal and necessary stage of development on their journey toward adulthood.

To arrive at a universal truth regarding human development and behavior, Bowlby felt it was necessary to utilize several fields of scientific inquiry rather than rely on existing theories of psychoanalysis alone.

The plan contains information on the child's individual strengths and needs, family goals, strategies and services necessary to facilitate the infant's or toddler's development and learning, with the participation of the family.

Born out of a series of parents» workshops that combined Siegel's cutting - edge research on how communication impacts brain development with Hartzell's decades of experience as a child - development specialist and parent educator, this book guides parents through creating the necessary foundations for loving and secure relationships with their children.

On the other hand, I read somewhere that chewing is a necessary exercise for the jaw and for speech development so they also eat fried meat but not cooked too strong.

Replicating and Scaling Up Evidence - Based Home Visiting Programs: The Role of Implementation Research (PDF - 337 KB) Paulsell (2012) Encyclopedia on Early Childhood Development Discusses implementation research in the home visiting field, how research can be used to strengthen programs and improve targeted outcomes, and the conditions and supports necessary for effective implementation.

On the other hand, the development of all necessary systems and organs outside the womb is accelerated.

The north - west perspective is that we need such a development, but my arguments aren't emotional; they're based on economic outcomes that are just as necessary for the country as they are for the north - west.

The First Lady of the Republic, Mrs. Rebecca Akufo - Addo has stated that taking the necessary steps, to vigorously fight Malaria will have positive implications for human development and business and economic growth on the African continent.

This means that the key to building a weapon, and consequently controlling weapons development is controlling the refinement of U-235 (which is necessary for the creation on Plutonium - 239).

While the tenets of Blair's AGI are fairly clear — focusing on strengthening African leadership and good governance and boosting economic growth through sustainable development of infrastructure — a visit to the AGI website is less than clear on how the initiative will (or can) ensure the necessary good governance.

The resulting conclusions will increase our understanding of the impact of electoral competition on the all - too - scarce resources necessary for development.

c. Urgent action to step up lending to SMEs through the imposition of net lending targets on semi state owned banks as in the Coalition Agreement, including consideration of whether it is necessary to split them in to good and bad banks, and further development of the Business Bank and Green Investment Bank.

«These updates to the county's Farmland Development Rights program will ensure that current and future generations of Suffolk County farmers will have the economic tools necessary to succeed on Long Island,» Mr. Bellone (D - Babylon) wrote in a statement.

Reporting for the Excelsior Jobs Program is a good model to follow because it includes most of the metrics necessary to have a complete picture of recipients» commitments, actual performance, and incentives issued.3 Another good example is the downloadable data on Industrial Development Agency (IDA) projects provided on the Office of the State Comptroller (OSC) website, although quality metrics should include annual numbers, and not just totals.4 See Appendix A for a recommended list of metrics.

Following the bid - rigging scandal involving several upstate economic development projects last fall, it is clear stronger protections on the procurement process are necessary.9 All state agencies, public authorities, and affiliates should be required to have competitive and transparent contracting processes.

Development, Mr Abubakari observed, is a progressive venture and cumulative as time goes on, adding that no government has been able to provide all the necessary things for workers to deliver service to their populace.

The Hudson Valley Food and Beverage Alliance at the Marriott Pavilion on the CIA campus will operate the Training and Workforce Development Center, and provide farms and agri - businesses in the Hudson Valley with the resources, training, services, and support necessary to recover from the natural disasters, sustain their current farming operations, as well as expand and create economic opportunities.

«These updates to the County's Farmland Development Rights program will ensure that current and future generations of Suffolk County farmers will have the economic tools necessary to succeed on Long Island,» Mr. Bellone said.

He attempted to strike a middle ground on the controversial issue of development in The Bronx, stressing that both affordable housing and mixed - income housing are necessary to make the borough a better place to live.

«The key was old - fashioned canvassing, knocking on doors every day... and being able to deliver the resources and the necessary dollars for development,» Ayala said.

Renovator Training Supports Local Employment «Joint Initiative Partners MVCC, LPP and Workforce Development» Oneida County Executive Anthony J. Picente, Jr. today announced a free training program designed to provide as many as ten persons with construction experience who are currently unemployed the necessary skills to work on pre-1978 built houses that may have lead - based paints.

Clinton County and town of Plattsburgh officials have also been working on an infrastructure evaluation for the former Clinton County Airport, identifying what's necessary to achieve future development.

Further investigation, says Resar, showed that these unusual properties arise from the ability of HMGA1 to turn on several genes involved in the Wnt pathway, a network of proteins necessary for embryonic development and stem cell activity.

With the development of on - board electronic systems3 and wireless technologies, the miniaturization of energy storage devices has become necessary.

Picking up on recent discoveries that the Notch - modifying enzyme known as Rumi is necessary for animal development and that various mutants of Rumi are linked with a form of skin hyperpigmentation known as Dowling - Degos disease (made by scientists at the Baylor College of Medicine and the University of Bonn, Germany), Li's group became focused on this particular enzyme.

Pardón proposed several necessary potential innovations, including new water testing methods available to anyone at any time, the development of ways to reduce viruses and protozoan parasite pathogens in water, and improved on - site sanitation methods.

The development of ShakeAlert has shown that a dense network of seismic stations, swift transfer of seismic data to a central processing and alert station, speedy paths for distributing alert information to users, and education and training on how to use the alerts are all necessary for a robust early warning system, said Monica Kohler, a Caltech research faculty member in the Department of Mechanical and Civil Engineering.

Cancers would be caught at their earliest stage and other stages of development, and doctors would have the necessary protein or genetic information from these captured cells to customize your treatment based on the specific markers for your cancer.