Sentences with phrase «on normal»

Simon's strategy is to compare the effects of a drug on a normal strain of yeast and a strain with a mutation in one of the many genes that affect normal cell division - a property that is disrupted in cancerous cells.

First, they found that the mice on a high - fat diet had many more intestinal stem cells than mice on a normal diet.

Recombinant human granulocyte colony - stimulating factor: effects on normal and leukemic myeloid cells.

During this period, the mice on the high - fat diet gained 30 to 50 percent more body mass than mice fed a normal diet, and they developed more intestinal tumors than mice on a normal diet.

Successful targets for therapies are specific to tumor cells and not found on normal cells.

GD2 is also found on normal peripheral nerves.

When one simply looks at the Lauer curve data transposed on a normal linear graph, as discussed, those data indicate that having a single R01 is about the least productive NIH funding situation, far less productive than 3 — 5 R01s.

One even showed greater dopamine activity in the injured side of the brain than on the normal side, indicating, says Jaenisch, that «these IPS cells could be used also for generating function of dopaminergic neurons that could have therapeutic value.»

Subjects were recruited from the UCSF Memory and Aging Center's longitudinal observational studies and from a Stanford University study on normal aging and mild cognitive impairment.

«More importantly, a retrovirus can infect only dividing cells such as reactive glial cells, but it does not affect neurons, which makes it ideal for therapeutic use with minimal side effect on normal brain functions.»

The acrosome, a structure essential for fertilization, appears as a green, moon - shaped cap on normal sperm (left), but is missing or misshapen on sperm produced by mice treated with NB - DNJ (right).

Mobile DNA molecules that jump from one location in the genome to another may contribute to neurological diseases and could have subtle influences on normal brain function and behavior, according to a study published October 30 in Nature.

When vehicles are given a range of speeds based on a normal distribution but allowing for road speed limits and differences in top speeds, real - life situations begin to crop up on the simulation.

Knight says some of the strongest evidence for a bacterial role in circadian - linked diseases lies in the final phase of the study, when the research team analyzed fecal samples from two people on a normal schedule and two more who had recently flown from the United States to Israel.

This means that, whether it's a human or a mouse, the pressure on normal excrement is the same.

«We hypothesized that for a given pair of targets that differ by a single point mutation, a set of mismatches could be identified in the guide RNA that would eliminate Cas9's activity on the normal sequence while maintaining robust activity on the one with a deleterious point mutation.

I slept much less than on a normal night.

The antigen is found on the normal cells of just a few tissues.

«Because normal cells don't acquire super-enhancers on these master regulators, the agent had a profound impact on neuroblastoma tissue but not on normal tissue,» says the study's senior author, Rani George, MD, PhD, of Dana - Farber / Boston Children's.

They initialized SELFE by entering data on normal tidal conditions along the model's open - ocean boundary, which is drawn almost 1,500 miles offshore.

The third group of sheep was placed on a normal or control diet from four months before conception, until one week after conception.

That research showed that mice on a normal diet who were exposed to low doses of antibiotics throughout life, similar to what occurs in commercial livestock, packed on 10 to 15 percent more fat than untreated mice and had a markedly altered metabolism in their liver.

Many of our everyday cognitive functions such as learning and memory rely on normal communication between the two regions of the brain - the hippocampus and prefrontal cortex.

«The unique aspect of this approach is the ability to improve symptoms and decrease joint damage while potentially avoiding any negative effects on normal immune responses and susceptibility to infections,» adds co-author Gary S. Firestein, M.D., dean and associate vice chancellor of Translational Medicine and director of the Clinical and Translational Research Institute at UCSD.

Astronomers infer its existence from its gravitational effects on normal matter.

MCC is associated with a virus, the Merkel cell polyomavirus, which is quite common, often found on normal human skin and surfaces that are frequently touched, Dr. Nghiem says.

«Conventional biogeography said vicariance was a more scientific explanation than jump dispersal because vicariance relied on normal, predictable processes, and jump dispersal relied on extremely rare, near - miraculous events,» Matzke said.

Although this human Gut Chip recreated the villus epithelium of normal intestine and enabled new insights into how flow and cyclic peristalsis affects intestinal differentiation and function, it could not be used to study processes that relied on normal intestinal cells from individual donors, which, for example, is crucial for studying patient - specific responses for personalized medicine.

The scientists carried out a battery of face space tests on normal individuals and on seven people with prosopagnosia.

He and his team looked through the scientific literature for data on normal walking, and found a complete dataset that represented one person's gait, including the angle of their joints, the weight of each leg segment, and the ground reaction force — the force between the ground and the foot — during a single step, or gait cycle.

The offspring did not lose yield compared with durum wheat on normal soils.

The researchers found that the virus binds to the CD21 receptor on normal breast cells, leading to infection.

In the office, on a normal day, watching actual police detectives use actual technology on actual cases presents a more complicated picture.

«These frequency changes can be decoded as audio on the normal FM receivers built into cars and smartphones.»

This study uncovered non-coding RNAs» cancerous role by using high - throughput sequencing techniques to analyse reams of genetic information on normal and diseased tissue as part of the Cancer Genome Atlas project.

This time, they found that the mice grew insulin - resistant, even when on normal diets.

The toxicity of chokeberry extract on normal blood vessel lining cells was tested and found to have no effects up to the highest levels used (50 ug / ml), suggesting that the cell death effect is happening in a way other than through preventing new blood vessel formation (anti-angiogenesis), a process that is important in cancer cell growth.

Next, Liao and his colleagues compared the effects of cardiac stress on normal mice and on those lacking KLF4 in their hearts.

In this research, after just four weeks on a high - fat or a high - sugar diet, the performance of mice on various tests of mental and physical function began to drop, compared to animals on a normal diet.

Experiments with mice show that after just four weeks on a high - fat or a high - sugar diet, the performance of mice on various tests of mental and physical function began to drop, compared to animals on a normal diet.

In the first ever report of the CRISPR - Cas9 genome - editing tool being used on normal human embryos, a team of Chinese scientists had mixed results, New Scientist writes.

When the scientists mixed nanocubes coated with DNA tethers on all six sides with nanospheres of approximately the same size, which had been coated with complementary tethers, these two differently shaped particles did not segregate as would have been expected based on their normal packing behavior.

Its presence is instead inferred through the gravitational pull it exerts on any normal matter around it.

If each particle of dark matter was instead small and light, there should be a lot of them to account for the amount of dark matter indirectly detected in the universe by its gravitational pull on normal matter.

El Nino's mass of warm water puts a lid on the normal currents of cold, deep water that typically rise to the surface along the equator and off the coast of Chile and Peru, said Stephanie Uz, ocean scientist at Goddard Space Flight Center in Greenbelt, Maryland.

It was based on the idea that homosexuality originated from a fear of taking on the normal qualities of one's gender.

Unlike some 3D glasses, the device uses no electronics, and works on normal 2D images or video.

«On a normal clinical MRI scan, you typically see the structural images of the brain, and for a mild brain injury like a concussion, we aren't able to see the underlying changes we were able to see using these advanced methods.»

But the cosmic ray team is able to piggyback on normal astronomical observations in their search for air showers.

The awarded resources amount to 20 million CPU hours - a computing time equal to approximately 500 years on a normal laptop.