Sentences with phrase «on normal cells»

The goal is to slow the growth of cancer cells, while producing minimal negative effects on normal cells.

Successful targets for therapies are specific to tumor cells and not found on normal cells.

These effects of radiation on normal cells cause treatment side effects.

«The challenge is finding targets that exist on other types of cancer cells but not on normal cells,» says pediatric oncologist Stephan Grupp of the Children's Hospital of Philadelphia, who worked with Porter on testing the treatment in mice.

Since PSMA's limited on normal cells, the therapy should hammer away at tumors while letting healthy tissues do their job.

In collaboration with investigators from the University of Copenhagen and University of Chicago, the researchers developed novel CAR T cells that express a monoclonal antibody called 5E5, which specifically recognizes a sugar modification — the Tn glycan on the mucin 1 (MUC1) protein — that is absent on normal cells but abundant specifically on cancer cells.

The study authors say that is because these vaccines have generally been made with tumor antigens that are too similar to antigens on normal cells: as a result, the body generates a weaker immune response to avoid harming normal cells, a process called immune tolerance.

Since then, other checkpoint inhibitors have been developed and commercialised to block a T - cell receptor called PD - 1 or its ligand PD - L1, present on some normal cells as well as cancer cells.

The SQZ approach minimizes effects on normal cell function and viability, thus dramatically expanding our ability to engineer cells.

However, the ECGC does not bind as strongly as the methotrexate which means it isn't quite as powerful but it also does not have a negative effect on the normal cells like methotrexate does (6).

The antigen is found on the normal cells of just a few tissues.

Peter's group has evidence this form of cell death preferentially affects cancer cells with little effect on normal cells.

The group revealed that AIM accumulates on the surface of mice HCC cells, but not on normal cells and showed that AIM interferes with proteins that normally suppress the complement cascade, triggering a process that leads to necrosis and elimination of the cancerous cells.

ONA has the potential to enhance existing anti-cancer drugs while also having little to no cytotoxic effects on normal cells.

The researchers demonstrated that blocking the PGD enzyme genetically or with a pharmacologic inhibitor reversed the epigenetic reprogramming and malignant gene expression changes detected in distant metastases, and also strongly inhibited their tumor - forming capacity, with no effect on normal cells or peritoneal pancreatic cancer controls.

In the lab, the antibiotics had no harmful effect on normal cells, and since they are already approved for use in humans, trials of new treatments should be simpler than with new drugs — saving time and money.

And very importantly, targeting Malat1 should not have a deleterious effect on any normal cells.»

If the transporters that are specifically induced in tumour cells compared with normal cells are identified, blocking the function of the induced transporters would offer a logical and effective strategy for cancer therapy with little effect on normal cells.

A new class of inhibitors offers a novel way to treat lung cancer with minimal toxic side effects on normal cells, according to a laboratory study funded through philanthropic contributions to the Lung Cancer Moon Shot.

Fasting is harder on cancer cells than on normal cells, he says.

Other research confirmed tocotrienol's protective effects on normal cells, with researchers reporting that the vitamin reversed cell cycle arrest and reduced DNA damage.