Sentences with phrase «on normal mice»

Next, Liao and his colleagues compared the effects of cardiac stress on normal mice and on those lacking KLF4 in their hearts.

Not exact matches

Read this post for a refresher, but the short of it is they wreck your gut with inflammation that is on the order of causing (in mice anyway) IBD if predisposed, and if with a normal immune system, say hello to chronic low - grade intestinal inflammation and metabolic syndrome.

Even in the first week after an election, the Whitehall agents of the 800 lb gorilla of executive power are hard at work on the tiny but irritating squeak of the parliamentary mouse rather than fixing the broken democracy in partnership with parliament, «back to normal working» is not the slogan that will restore the reputation and capability of our democracy.

These mice performed better than their normal counterparts on learning tests well into old age, and their brains did not exhibit the decline in neurogenesis typically seen in aged mice.

Reporting in The Journal of Neuroscience, they showed that neurons of the mouse forebrain depend heavily on NAD in normal cognitive function.

So Riqiang Yan, one of the discoverers of BACE1 and a neuroscientist at the Cleveland Clinic, and colleagues set out to learn what happens when mice who start life with normal amounts of BACE1 lose much of the enzyme later on.

When they examined mice genetically incapable of producing Helios, they found the animals beset by a T - cell and antibody attack on normal tissue.

In experiments on normal and MLL cells from mice and humans, the researchers demonstrated that beta - catenin is activated in cancer stem cells that prompt leukaemic blood cells to multiply.

If one eye is deprived of sight, they rapidly rewire their brains to compensate, then beat normal one - eyed mice on tests of visual acuity.

To investigate the longer - term effects of higher - than - normal acetylcholine levels on the brain, Hermona Soreq of the Hebrew University of Jerusalem and her colleagues first induced high levels of acetylcholine by forcing 26 mice to swim, an activity stressful to mice.

«The challenge is finding targets that exist on other types of cancer cells but not on normal cells,» says pediatric oncologist Stephan Grupp of the Children's Hospital of Philadelphia, who worked with Porter on testing the treatment in mice.

Mineral deposits and bone formation around toe joints of mouse with mutation in the ank gene (mutant foot shown on right, normal skeleton on left).

Kingsley's team had no idea what the normal gene does, but a team at the University of Tokyo had recently identified the genetic defect behind a similar mouse disease — and determined that its protein product normally generates pyrophosphate on the outside of joint cells to keep the joints scale - free.

However, when the researchers knocked out SIRT1 in endothelial cells of 10 - month - old mice, then put them on a four - week treadmill running program, they found that the exercise did not produce the same gains seen in normal 10 - month - old mice on the same training plan.

Lastly, they plan to vary the timing of exposure to the various diets in the mouse model of autism, by, for example, giving pregnant mice a high - glycemic index diet and then keeping their pups on a normal diet.

Put certain strains of mice on near - starvation but nutrient - rich diets, and they live 50 % longer than normal.

The mouse models of autism on a normal lab diet (with a medium glycemic index) are already known to generate fewer new neurons, and some of their existing cells and neuronal connections are abnormal compared with those of normal mice.

By switching Apc on, researchers turned swelling mobs of mouse cancer cells (above) back into normal intestinal tissue (below).

A new study has determined that mice that spent time running on wheels not only developed twice the normal number of new neurons, but also showed an increased ability to distinguish new objects from familiar objects.

They then injected the protein into elderly mice with normal immune systems, and found this reproduced the beneficial effects of cord plasma on both memory performance and LTP in the hippocampus whereas mice engineered to lack TIMP2 showed reduced LTP.

To determine what effect this had on fertility, Cook - Andersen's team set up an equal number of fertile male mice with 10 females lacking L2 in their eggs and 10 normal females.

Klebsiella pneumoniae is usually a normal resident in the mouth of healthy individuals, but as demonstrated in an experiment on specific pathogen - free mice treated and untreated with the antibiotic ampicillin, they can colonize in the gut and activate TH1 cells when antibiotics disturb the gut microbial balance and weaken tolerance for the colonization of oral bacteria reaching the intestine.

Knocking out a particular gene in muscle lets mice run twice as far as normal; knocking out the same gene in fat cells allows the animals to put on weight without developing type - 2 diabetes.

Mice with obesity - related diabetes, on the other hand, had normal levels of Tregs within the tissue, despite having more fat tissue.

Notably, they also achieved the same effects on p300 and Tregs in mice by using a drug that inhibits p300 in normal mice.

The control mice with normal C. mast on the other hand were able to fend off the fungus.

To solve this mystery, the scientists generated mice with normal or reduced levels of A2A receptors in astrocytes and compared them on tests of learning and memory.

Zeroing in on this kinase was encouraging, Goga said, because other researchers have shown that genetic - knockout mice that lack the entire family of PIM kinases are slightly smaller than normal mice, but «basically fine,» indicating that a drug targeting just PIM1 may have manageable levels of toxicity in breast cancer patients.

The blood sugar of the diabetic mice were made normal by the gene - therapy - treated human islets on the right.

Experiments with mice show that after just four weeks on a high - fat or a high - sugar diet, the performance of mice on various tests of mental and physical function began to drop, compared to animals on a normal diet.

In this research, after just four weeks on a high - fat or a high - sugar diet, the performance of mice on various tests of mental and physical function began to drop, compared to animals on a normal diet.

On the flip side, said Tran, PGC1 alpha transgenic mice, which had increased expression of these genes, were particularly resistant to various stressors and recovered from injury much more than quickly than animals with normal regenerative abilities.

Photoswitches inserted into retinal ganglion cells (RGC) of blind mice produce much less variety of response (all evenly red means the cells fire at the same time), while blind mice with photoswitches inserted into bipolar cells (ON - BC driven) exhibit much more variety in their retinal response to light, closer to that of normal mice.

This time, they found that the mice grew insulin - resistant, even when on normal diets.

The scientists soon determined that mice that lack IL - 17A activity healed wounds on their skin much more slowly than normal — very much like mice that lack DETCs.

The researchers will use pieces of normal mouse PrP as bait, hoping to fish out protein X when it latches on.

DNA sequencing of sperm from the grandfather mice and their pups also revealed epigenetic marks on the gene encoding M71 that weren't seen in normal mice.

Despite higher glycogen levels, glycogenin - deficient mice underperformed normal mice, reaching exhaustion earlier and covering a shorter distance while running on a treadmill.

On the other hand, as they aged, these «knockout mice» grew fatter than the normal mice, especially when fed a high - fat diet.

To overcome this hurdle, researchers genetically engineered human T cells to produce a CAR protein that recognizes a glycopeptide found on various cancer cells but not normal cells, and then demonstrated its effectiveness in mice with leukemia and pancreatic cancer.

Researchers found that prior to treatment, mice with tumors performed worse on learning and memory tests compared to their normal counterparts.

For comparison, bacteria grown in a laboratory on Earth in normal gravity infected another group of mice.

Experiments on mice and on heart cells obtained from infants born with congenital heart disease suggest that neuregulin 1, a human growth factor, can put infant heart cells on a path that mimics normal growth rather than stalling out.

The Mecp2 mutant mice were more sensitive to light touch; a small puff of air on their backs startled the rodents more than normal mice.

The one on top is from a normal mouse.

On one flank, the mice received healthy, normal cartilage; on the other, they received cartilage abundant with human RASFOn one flank, the mice received healthy, normal cartilage; on the other, they received cartilage abundant with human RASFon the other, they received cartilage abundant with human RASFs.

Sinclair's lab is now working on developing what he calls a possible «supermouse» with elevated levels of NAMPT to see if it lives longer and is more disease - resistant than normal mice.

That research showed that mice on a normal diet who were exposed to low doses of antibiotics throughout life, similar to what occurs in commercial livestock, packed on 10 to 15 percent more fat than untreated mice and had a markedly altered metabolism in their liver.

The news wasn't all bad: When Fischbach's team put obese mice on a diet, their mammary fat tissue had fewer myofibroblasts, suggesting losing weight could make a woman's fat tissue structure more normal and lower her breast cancer risk.

The researchers looked for genes that were turned on by dHAND in normal mice, but nonfunctioning when dHAND was shut down.