Harald Junge, Ph.D., CU - Boulder: Determine the effects of trisomy 21
on optic nerve development and function
The disease puts pressure
on the optic nerve through fluid build - up, and can irreversibly damage vision if not properly treated.
Then, the next spring, there was a sudden increase in pressure
on my optic nerve and my vision suddenly dropped off.
I also had two surgeries to relieve the pressure
on the optic nerve.
A day later, I had an MRI scan of my brain, and two days after that I was informed that I had several lesions
on an optic nerve behind my right eye which required IV steroid treatment.
A trip to the doctor reveals that the inoperable pituitary tumor that had been pressing
on his optic nerves since he was a teenager has miraculously shrunk.
In 20th Century Women, a far easier session
on the optic nerves, Fanning plays a lustrous, restless, teenage sunflower in Santa Barbara who moves like a pop tune through air, teaches a young lad the proper dude way to smoke and swagger, and mimics the whimpering moans of male lust with fond disdain.
Not exact matches
The
optic nerve is working, and your baby will often turn her / his head to look in the direction of a light shining
on your belly.
The first symptom of a similar problem appeared
on my right
optic nerve when I was 16 years old.
It has fallen
on the blind spot of your left eye, a small patch of retina called the
optic disk that is devoid of receptors (an imperfection caused by the
optic nerve piercing the retina as it exits the eyeball).
«Our data clearly showed that one of the protein receptors
on white blood cells called CXCR3 brings white blood cells to the
optic nerve in response to production of its binding partner CXCL10 by damaged
nerve tissue,» said Zhang.
The oldest known drawing of the nervous system shows a large nose at the bottom, eyes
on either side, and a hollow
optic nerve that flows out of each one towards the back of the brain.
In 2010, they decided to collaborate to learn about zinc's impact
on retinal ganglion cells, which receive visual signals and form the
optic nerve that delivers information to the brain.3
In fact, so much of the progress that we're making in laboratories, including mine, is
on developing neuroprotective therapies that can protect the retina from degeneration, regenerate
optic nerve fibers all the way back to their targets in the brain, and even replace damaged retinal ganglion cells with self - therapies that completely rebuild the
optic nerve.
(E) Retinal ganglion cell axons exit the eye as the
optic nerve (white arrow), pass under the brain and out of view then reappear
on the contralateral side (arrowhead).
First based
on our completed genetic study we will test if pharmacological inhibition of an identified protein via direct eye injection can promote long distance
optic nerve regeneration or whether, based
on strong preliminary data, manipulation of another novel gene can induce such regeneration.
We seek to determine whether a particular type of imaging, known as «polarization - sensitive» imaging, is capable of reporting
on the integrity of sub-microscopic structures within
optic nerve fibers at an early stage of damage from glaucoma, preceding their complete degeneration and loss from the eye.
We seek in this proposal to determine whether a particular type of imaging is capable of assessing and reporting
on the integrity of sub-microscopic structures within
optic nerve fibers at an early stage of damage preceding their complete degeneration and loss from the eye.
I have been working in the field of glaucoma research,
on pathophysiology and diagnostics, for the past 18 years, and have become increasingly interested in the use of advanced imaging techniques for characterization of glaucomatous changes within the retina and
optic nerve head.
The pattern of RGC loss in patients as well as information obtained from laboratory research all point to the fact that an important site of pathology occurs at the
optic nerve head, a region where the axonal cell processes of RGCs exit the eye
on their way to the visual centers of the brain.
We're focused
on glaucoma and it has to do with a set of very surprising findings in a region that we know is critical for axon loss in glaucoma, which is the
optic nerve head.
Dr. Otteson studied how retinal ganglion cells turn
on and off the genes that regulate the normal patterns of connections during
optic nerve development.
Identifying factors that regulate directional growth of regenerating RGC axons to their targets will provide invaluable information
on developing future therapies to repair degenerated
optic nerve following glaucoma.
Towards this goal, we first discovered that
optic nerves regenerate physically
on the surface of astrocytes which are the support cells in the
optic nerve.
On the surface, the disease appears relatively simple, with high pressure (intra-ocular pressure, or IOP) within the eye associated with the death of cells in the retina and
optic nerve dysfunction.
Another example, this is something that's going
on in my laboratory, is that we're starting to look at protein and fat deposits in the retina and the
optic nerve that we hopefully can measure in blood serum that tell us that the disease is progressing early
on.
The Nobel Prize - winning physiologist Haldan Hartline discovered that the
optic nerve of Limulus polyphemus could be frayed into thin bundles, and then further split apart until he had a single fiber
on which to run his experiments.
Glaucoma is actually a series of diseases that damage the
optic nerve (the
nerve that connects the retina of the eye to the brain), often when too much pressure is put
on the eye due to fluid buildup.
Sneezing generates a lot of pressure in your head, which can in turn put pressure
on the retina — the light - sensitive layer of tissue inside your eyeball — or
optic nerve.
While the mechanism of glaucoma vision loss isn't completely understood, the majority of research has cantered
on eye pressure increase slowly but surely injuring the
optic nerve.
Nutritional
optic neuropathy, a damage of the
optic nerve with reduction of color vision and visual field defects may be caused by lack of certain vitamins or other nutrients in a chronic alcoholic
on a poor diet [19].
If you find that your cat is circling for no apparent reason — meaning she's not trying to make a nest
on your bed — this may be a sign that she could be suffering from a tumor that's affecting her
optic nerves and, therefore, her vision.
As of right now, my dog has no aura before the event and acts fine both during and after the episode, so I can only assume that it's something going
on specifically in the occipital lobe of the brain or the
optic nerve.