Sentences with phrase «on other cell types»

This is basically tweaking the molecules: making small chemical changes to the compound in hopes of finding something that could block the growth of blood vessel cells initially in the culture dish without having toxic effects on other cell types.

Although 4 - 1BB was originally thought to be only expressed after activation of conventional CD4 and CD8 T cells, it is constitutive (NK cells) or induced (NKT cells, dendritic cells) on other cell types.

Not exact matches

Some of these risks include the presence of cytomegalovirus (CMV), hepatitis, human immunodeficiency virus (HIV), human T - cell leukemia virus type 1 (HTLV - 1) or other viruses on the pump parts that were exposed to the previous mother's breastmilk.

Breastfeeding is contraindicated in infants with classic galactosemia (galactose 1 - phosphate uridyltransferase deficiency) 103; mothers who have active untreated tuberculosis disease or are human T - cell lymphotropic virus type I — or II — positive104, 105; mothers who are receiving diagnostic or therapeutic radioactive isotopes or have had exposure to radioactive materials (for as long as there is radioactivity in the milk) 106 — 108; mothers who are receiving antimetabolites or chemotherapeutic agents or a small number of other medications until they clear the milk109, 110; mothers who are using drugs of abuse («street drugs»); and mothers who have herpes simplex lesions on a breast (infant may feed from other breast if clear of lesions).

«By observing entorhinal - hippocampal neurons based on their birthdate, we realized that these cells were somehow special and very different from the other surrounding cell types, which was instrumental to find out how and to what extent they influenced the assembly of the network.»

«The challenge is finding targets that exist on other types of cancer cells but not on normal cells,» says pediatric oncologist Stephan Grupp of the Children's Hospital of Philadelphia, who worked with Porter on testing the treatment in mice.

LPA receptors are all over neural progenitor cells, which go on to form neurons and other types of cells in a young brain.

These cells were not affected in patients with SLE, dermatomyositis, or other type I interferonopathies, however, suggesting that the source of interferon - can vary depending on the autoimmune disease.

Panoskaltsis - Mortari, an author on one of the other recent lung - engineering studies using a similar matrix, and her group presented data at a conference last month showing that iPS cells can differentiate into a key type of lung cell when grown on decellularized matrices.

«Although right now we are focusing on developing a cancer vaccine, in the future we could be able to manipulate which type of dendritic cells or other types of immune cells are recruited to the 3D scaffold by using different kinds of cytokines released from the MSRs,» said co-lead author Aileen Li, a graduate student pursuing her Ph.D. in bioengineering at Harvard SEAS.

She found that the brain depends on a type of immune cell known as the T cell, which normally kills infected cells or leads other immune cells in a campaign against foreign invaders.

Further examinations of the inactive X in lymphocytes found that it lacked the heterochromatic marks found on the inactive X in other cell types.

Traditional methods for sorting cells rely on fluorescent molecular tags, designed to stick to the surface proteins present on certain types of cells but not on others.

«This technique could be applied to other cell types of the immune system — anywhere the receptors on the membrane are renewed often,» says Griessinger.

The potential influence of founder cells is profound for regenerative medicine and other medical applications, since they suggest that the cell line should be selected based on the desired cell type.

In others, the researchers altered a gene that regulates phospholipids, the primary type of fat in cell membranes, which spurred the cells into producing more cholesterol on their own.

hESC researchers George Daley of Children's Hospital Boston and Sean Morrison of the University of Michigan told the panel why research on other types of stem cells, such as adult stem cells and so - called induced pluripotent stem cells (iPSCs), can't substitute for work on embryonic cells.

Also on the horizon for the Penn scientists are applications of CAAR T cell technology for other types of autoimmunity.

Solid oxide fuel cells (SOFCs), based on an oxide ion conducting electrolyte, have several advantages over other types of fuel cells, including relatively inexpensive material costs, low sensitivity to impurities in the fuel, and high overall efficiency.

The two cell types formed structures reminiscent of bone growth plates — cartilage on one side, bone and marrow on the other, they report online 6 September in the Proceedings of the National Academy of Sciences.

The new approach relies on a photoelectrochemical (PEC) device, a type of solar cell that can potentially split water molecules more efficiently than other methods.

For the first 5 years, Spalding worked on finding an effective way of separating the roughly 20 million neurons in the dentate gyrus from other types of hippocampal cells and then extracting their DNA.

So to be able to make the most efficient use of the sunlight, one of the possibilities is to build tandem - type structures, in other words, to fit the cells manufactured with different polymers one on top of the other,» explained Etxebarria.

Cancer cells resemble stem cells not because they can turn into other cell types, but because in developmental terms, they seem to go in the opposite direction: they begin to run through multiple layers of stop signs and barricades and just keep on multiplying.

«We were interested in the origins of lamprey gut neurons because in other vertebrates they arise from a particular embryonic cell type, called neural crest cells,» says Stephen Green, postdoctoral scholar in biology and biological engineering and co-first author on the paper.

Our long - term goal, therefore, is to explore the potential to genetically disrupt both ccr5 and cxcr4 for cell replacement therapies in HIV infected individuals, and in the case of cxcr4 do so in a way that specifically targets CXCR4 on T cells and not the many other cell types on which it is expressed.

They're also interested in exploring the effect of other types of infertility - associated mutations on germ cell production.

In a quickly executed study that reflects the global public health threat posed by Zika, the researchers compared Zika's effect on cells known as cortical neural progenitor cells to two other cell types: induced pluripotent stem cells and immature neurons.

Researchers from immune biology professor Annette Oxenius's group have now discovered what keeps NK cells from killing off their «colleagues from the other department» of the immune system: healthy CD8 + cells are able to detect the immune messenger substance type 1 interferon, which binds to specific receptors on the surface of these immune cells and thereby conceals their stress.

Other forms of cell - cell interaction, on the other hand, are only effective in mixed population structures; these include, for example, cross-feeding mutualisms in which different cell types depend on close proximity to benefit each other [17 —Other forms of cell - cell interaction, on the other hand, are only effective in mixed population structures; these include, for example, cross-feeding mutualisms in which different cell types depend on close proximity to benefit each other [17 —other hand, are only effective in mixed population structures; these include, for example, cross-feeding mutualisms in which different cell types depend on close proximity to benefit each other [17 —other [17 — 19].

Professor Chien's research on how blood flow regulates interaction between the blood stream, blood cells and artery walls also leads to new information relevant to other types of cells, e.g., stem cells and cancer cells.

Depending on characteristics such as how many tumor cells, blood vessel cells, and immune cells are touching each other, the tumor microenvironment can nearly triple the chance that a common type of breast cancer (estrogen - receptor positive / HER2 negative) that has reached the lymph nodes will also metastasize, Condeelis and colleagues showed in a 2014 study of 3,760 patients.

«When one cell type produced Wnt1, which we know the tumor depends on, the other type sensed it.»

To avoid such perturbations, researchers have developed a computer program that can distinguish between cell types and identify subcellular structures, among other features — all without the fluorescent probes our human eyes rely on.

We invite original innovative research on the rational engineering of plant systems at all levels, including proteins, protein complexes, sensors, metabolic and signalling pathways, microcompartments such as carboxysomes, subcellular compartments, cell types or tissues, as well as the engineering of novel plant hybrid species and the interactions of plants with viruses, bacteria, and other organisms.

Moreover, there are yet other cell types — such as visceral adipose tissue macrophages and cytotoxic CD8 + T - cells — in which the age - related supernumerary accumulation of dysfunctional and apoptosis - resistant cells appears to play a highly deleterious role on tissue function, but where the cells are not «senescent» cells in the classical sense of p16Ink4a expression and the senescence - associated secretory profile observed in senescent fibroblasts.

Activated ERK1 / 2 modulates the functions of several transcription factors, protein kinases, protein phosphatases, cytoskeletal proteins, signaling molecules, apoptosis - related proteins, as well as other types of proteins [32], while activated AKT modulates the function of numerous substrates involved in the regulation of cell survival, cell cycle progression and cellular growth [33, 34], whereas JNK acts as pro-apoptotic as well as anti-apoptotic depending on the conditions [35].

(Adult stem cells, on the other hand, are much more limited in their potential; they can usually only become a few different cell types, and consequently are not applicable for treating as wide a variety of diseases as hESCs are.)

«We showed that there are markers on these stomach tumour cells that indicate they would be responsive to a type of immunotherapy called immune checkpoint inhibitors, in particular anti-PDL1 immunotherapy, which is already used with great success in the treatment of melanoma and certain other cancers.

The functional effect of genetic variants is not a binary or a constant phenomenon, but depends on the context of the variant — including the cell type, external environment, and the genomic environment of other variants in the genome and the haplotype.

The research published in the journal Nature Biotechnology shed more light on which genetic factors are critical in the reprogramming of adult skin cells to become other types of cell.

Dula Parkinson, a research scientist at Berkeley Lab who works on the NASA - related projects, said the same sample cell can stretch or compress a range of different materials in other types of experiments, too: «It can work for anything you want to crush or pull on,» he said.

Biomedical engineers at Case Western Reserve University in Cleveland, Ohio, and Worcester Polytechnic Institute in Worcester, Mass. are growing tracheas by coaxing cells to form three distinct tissue types after assembling them into a tube structure - without relying on scaffolding strategies currently being investigated by other groups.

In addition to CAR - T cell therapy, we focus on other types of immunotherapy research, such as vaccine therapy and checkpoint inhibitors.

On the other hand, a Brs3 agonist promoted insulin secretion in both rodent insulinoma cell lines and in islets isolated from wild - type but not Brs3 mutants [53].

The female sifaka, though, show how some animals can chance on trichromacy even if most of the other members are dichromats, meaning they have only two types of cone cells.

The current ethical, political, and scientific debates on stem cells pitch the benefits and limitations of 2 cell types against each other, adult vs embryonic stem cells.

We found that it is very selective and potent at stopping the growth of blood vessel cells without having negative effects on the growth of other cell types from the eye and elsewhere in the body.

On the other hand, the SCP1 expression is detected in germ cells of SCP3 KO mice, though the structure of the synaptonemal complex and localization of SCP1 in the complex are abnormal in comparison to the wild - type germ cells [50].

Like transcription factors, these genes turn on other stem cell genes and turn off those associated with different cell types.