Sentences with phrase «on particular proteins»

He said the next step is to study how we can prevent these aberrant SNO reactions on particular proteins like PINK1.

In research published this week in the Journal of Neuroscience, University at Buffalo scientists and colleagues focused on a particular protein, called a transcription factor, that regulates gene activity necessary for the development of one type of retinal neuron, the horizontal cells.

Not exact matches

[breakfast] the usual veggie packed scramble with whole wheat toast and a Laughing Cow on the side, this particular scramble had spinach, mushrooms, and orange bell pepper [lunch] a less picturesque version of this salad, let's blame that on the extra Feta [snack] protein shake with strawberry, frozen banana, and vanilla protein powder [dinner] layered nachos (see recipe below) * unpictured snacks * half whole wheat bagel with PB, baked sweet potatoes

Restaurants — in particular, Mexican restaurants — are adding tofu as another protein option on their menus, such as tacos and enchiladas available with chicken, beef, pork or tofu.

This particular stew is based on a recipe for sambar — a mung dal (yellow split mung beans that are protein - rich and affordable) stew that comes in hundreds of variations.

Before we get into the details of what makes a particular product «the best protein powder for children,» we need to be clear on a few things.

Lysine is of particular interest, as this is the first limiting amino acid in people whose diets are mainly based on cereals and vegetable protein sources.

Better yet, this particular take on the protein bar is vegetarian.

On this particular day I tried activated cashew nuts as the main protein and the resulting soup was so delicious it was worthy of it's own blog post!

«Over the course of 2018 and beyond, we expect to see a significant increase in launches of whey protein ready - to - drink beverages, with a particular focus on clear protein waters,» said Anne Louise Friis, business development manager at Arla, adding that it has traditionally been challenging to use whey in clear drinks without compromising taste, texture and appearance.

But today, I want to shine the light on one particular brand of collagen that's caught my attention (and one that you've told me is your favorite, too), Vital Proteins.

In particular, he has focused on targeting the gene coding for flagellin protein b, or flaB, which has proved to be quite distinct from one genospecies to the next.

Walter Fiers discovered that targeting a particular protein segment on the influenza virus might just do the trick

The amino acid backbones snap together like beads on a string, the side chains arranged in a particular order for each protein.

Up until now, there has been a heavy focus on the role of animal protein and cooking in the development of the human brain over the last 2 million years, and the importance of carbohydrate, particular in form of starch - rich plant foods, has been largely overlooked.

In recent years, scientists have been working on developing these proteins for experimental use, but until now it was more of a trial - and - error process to create proteins that would bind to a particular RNA sequence.

Tuncay Baubec, professor at the Department of Molecular Mechanisms of Disease at the University of Zurich, and his team have shown that one particular protein plays an important part in this process: The DNA methyltransferase 3A (DNMT3A) enzyme is responsible for positioning the methylation to the right place on the DNA.

As autumn arrives in the northern hemisphere, experts are on tenterhooks: a particular worry is that swine flu will hybridise with bird flu to create a readily contagious human flu armed with a lethal H5 surface protein.

As a grad student, I once spent 2 months demonstrating that three particular amino acids on a protein in the arabinose operon (the group of genes that allows bacteria to metabolize a certain sugar) do not play a role in causing that protein to bind to other copies of itself.

In actual fact, the gene varies depending on the tissue where it is located (cerebral cortex, cerebellum, olfactory epithelium, etc.); in particular, what varies is the point in the «string» of code at which protein synthesis starts.

siRNAs are very small molecules that carry genetic information to cells, but unlike DNA that can turn genes on, siRNA interferes with the production of particular proteins and can turn cancer genes off.

For the study, the researchers used an unusually large dataset made up of the sequences of 128 proteins from 55 species, including representatives of all the major animal groups, focusing in particular on those that diverged very early.

In recent years, our group alone has published 30 to 40 research papers annually not only on genomewide patterns, but also on in - depth analysis of particular protein families.

Steve: The on - off switch system is surprisingly — I don't want to say, simple — but straightforward, in that we have these methyl groups or acetyl groups, and depending on which one you have in a particular area of the protein surrounding the DNA, you're either going to activate the gene or turn it off.

Researchers knew that a particular protein on the microbes» membranes was somehow responsible for making ice form.

In particular, Nguyen and Ehrenstein discovered that adalimumab increases the expression of TNF on the surface of patient monocytes and promotes the association of these TNF molecules with receptor proteins on the surface of regulatory T cells.

New work led by Carnegie's David Ehrhardt hones in on how one particular organizational protein influences cytoskeletal and cellular structure in plants, findings that may also have implications for cytoskeletal organization in animals.

Photoactivated localization microscopy incorporates into a sample special fluorescent proteins that can be toggled between on and off states when hit with a particular wavelength of light.

Bioinformatics covers huge areas of expertise these days, so I'll focus on my own particular area: using protein structural predictions to link DNA and protein sequences to their functions.

In a new study, scientists from the Florida campus of The Scripps Research Institute (TSRI) have shed new light on these complex processes, showing that a particular protein plays a far more sophisticated role in neuron development than previously thought.

At that point, a particular type of protein called a transcription activator can kick - start the molecular process by which a gene gets turned on.

The investigators then used mass spectrometry to home in on the particular regions in each protein to which the anesthetics were bound and these turned out to be domains that are critical for the proteins» contractile function.

So, eventually they homed in on a particular kind of protein called zonulin, which is involved somehow in managing or manipulating the lining of, you know, the permeability of that intestinal wall.

«Protein associated with Parkinson's travels from brain to gut: New laboratory study provides clues on a particular pathway of «alpha - synuclein» diffusion.»

Fourches and Jeremy Ash, a graduate student in bioinformatics, decided to incorporate the results of molecular dynamics calculations — all - atom simulations of how a particular compound moves in the binding pocket of a protein — into prediction models based on machine learning.

Focusing on a particular group of enzyme - blocking compounds called protein kinase inhibitors, they identified 31 compounds that inhibit malaria growth without harming the host.

Tissues are often divided into sub-structures, based on visual appearance, or by expression of particular proteins indicating a specific function of that sub structure.

In order to produce a protein, the corresponding body plan encoded on a particular section of the DNA has to be copied in so - called messengerRNA (mRNA) and thus multiplied.

But a study on lab rats who got hooked on alcohol and were then put through detox, showed that one particular protein was responsible for the retention and revival of these memories.

For example, turning one particular subtype of receptor on or off using light could influence whether the cell fires or not and provide valuable information about the protein's role.

Other theories and lines of research have begun to prosper due to the lack of tangible human results for anti-amyloid immunotherapies, in particular that neurofibrillary tangles of misfolded tau protein are just as much a target for clearance as is amyloid - β, and that perhaps it is time to focus on the decline of known clearance mechanisms rather than the amyloid itself.

The laboratory has a particular focus on neuronal polarity — the structural and functional differences between axons and dendrites — and the mechanisms that underlie polarized targeting of membrane proteins.

From previous research on genetic instability, conducted by the Pearson lab and others, the researchers suspected that the dramatic difference between the mice might boil down to variances in one particular biological process, called mismatch repair, and more specifically one of its major players, the MSH3 protein.

Western Blotting relies on the specific binding between the protein - of - interest and an antibody raised against this particular protein.

While he insists much remains to be learned about ERAD in particular, Rapoport recently added a fourth project, the mechanism of protein import into peroxisomes, to attract students and postdoctoral fellows who want to make an impact on a less - studied biological problem.

This webcast features: Jamie Freeman, PhD, Product Manager, Horizon Discovery While great strides have been made in increasing the yield of biotherapeutic proteins, these have been achieved mainly through process improvement with a particular focus on media and feed strategies.

Each colored dot represents the abundance of that protein family (measured on a logarithmic scale) for a particular fecal sample taken from a healthy person (green dots) or a person with IBD (red, blue, purple dots).

Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters

Penn State College of Medicine researchers homed in on the role of a particular cytokine — a cell - signaling protein — called interferon gamma, that is involved in the immune system.

He introduced a number of important techniques in chemical modification of proteins, in particular based on reversible amidination and trifluoroacetylation of lysine residues.