Sentences with phrase «on preclinical studies»

Not exact matches

Some retrospective studies and preclinical work have indicated that it might also lower a person's risk of cancer, though at least one clinical trial wasn't able to show that it had any protective effect on esophageal cancer.

The study chronicles the use of Vasalgel ™ in groups of rhesus macaques — confirming previous preclinical findings in rabbits on the efficacy of the new device and offering a new tool to colony managers.

Independent of these preclinical studies, Clementia Pharmaceuticals is currently conducting phase 2 clinical trials in individuals with FOP, based on the 2011 preclinical results published by Pacifici and Iwamoto.

Elizabeth Pollitzer comments on the under - representation of women in preclinical, clinical and epidemiological studies (8 February, p 30).

The preclinical study looked at the effect of DHA on lupus lesions in the lungs and kidneys of female mice that were already genetically predisposed to the disease.

The study can be seen in Cell Reports and provides an explanation for why the clinical trials for Alzheimer's disease drugs have failed and gives new light on the discord between preclinical and clinical findings.

The issue of sex is particularly acute in preclinical studies of Rett syndrome, a disorder caused by mutations in a gene located on the X chromosome.

In the preclinical study, WRAIR and the Beth Israel Deaconess Medical Center tested two Zika virus vaccine candidates: a DNA vaccine developed at Harvard based on a Zika virus strain isolated in Brazil, and a purified inactivated virus vaccine developed at WRAIR based on a Zika virus strain isolated in Puerto Rico.

The current study is built on more than 20 years of preclinical research on memory codes led by Sam Deadwyler, Ph.D., professor of physiology and pharmacology at Wake Forest Baptist, along with Hampson, Berger and Song.

According to the authors of the study, in future researches it will be necessary to know about the action mechanism of the new products - highly selective and with low cell toxicity on in vitro tests - and broaden preclinical studies with laboratory animal models.

After preclinical studies, a gene therapy trial for SCID - X1 was initiated, based on the use of complementary DNA containing a defective γc Moloney retrovirus — derived vector and ex vivo infection of CD34 + cells.

An experimental drug has shown promise in treating influenza, preventing lung injury and death from the virus in preclinical studies, according to University of Maryland School of Medicine researchers publishing in the journal Nature on May 1.

Because of a lack of standardised and harmonised preclinical studies, there is limited information we can so far obtain from literature on the relative predictive value of different animal models and alternative methods for vaccine evaluation.

PNP Therapeutics, Inc. — a company based on a gene - therapy technology developed by scientists at Southern Research Institute and the University of Alabama at Birmingham (UAB)-- has found an approach that has abolished otherwise unmanageable human cancers in preclinical rodent studies.

«Lithium, long used in mental health as a highly effective mood stabiliser, has been on the radar as a potential disease modifying treatment for Alzheimer's disease with positive evidence from preclinical studies and a number of small clinical trials.

Together our data support the notion that targeting DGKζ, a negative regulator of T cell activation, or other regulators of Erk activation, could be useful in the treatment of human malignancy and that additional preclinical studies of intracellular «brakes» on T cell activation are warranted.

Together, this translational program is developed within the National Cancer and Cognition Platform (CNO / Ligue Nationale contre le cancer), with the aim to collaborate in a structured way with French oncology groups, research teams as well as pharmaceutical industry, by providing preclinical models and guidance on standard operating procedures for ancillary or future studies in identified population at risk.

M1: Passive transfer studies in preclinical model performed; Report on protection by passive therapy with human immune IgG

Recent approval from the U.S. Food and Drug Administration to begin clinical studies was based on compelling activity upon IACS - 10759 treatment in multiple preclinical models of AML.

Preclinical studies of the effects on this drug on neurodegeneration have been done but do not appear to have been published so I do not know which disease models were used.

Trials such as the Anti-Amyloid in Asymptomatic Alzheimer's Study, or A4 Study, are now focusing on enrolling cognitively normal participants who have biomarkers suggestive of «preclinical AD,» in order to delay the onset of cognitive impairments.

The Walter Reed Army Institute of Research (WRAIR), in collaboration with the Beth Israel Deaconess Medical Center (BIDMC), has completed a second round of preclinical studies on a promising Zika... Read More

«We are encouraged by the preclinical data emerging on SRK - 015, including the effects upon fast - twitch muscle fibers that are particularly relevant for SMA as well as its selectivity profile, which may be very important when considering chronic therapy in children,» said Karen S. Chen, PhD, Chief Scientific Officer of the SMA Foundation and a co-author of the study being presented at the Cure SMA Annual Conference.

Studies conducted on these preclinical disease models, however often have limited ability to predict effects in patients.

The social venture company within the foundation is moving fast on getting the first steps done; however, it won't have enough money to finish the project, and has conducted fundraising campaigns which have helped to support the preclinical studies that are paving the way for the first human trial.

The study investigated the effect of dietary fat (classified as total, saturated, monounsaturated, polyunsaturated, omega 6, omega 3 and trans) on a range of preclinical and clinical outcomes in women having IVF.

A preclinical study conducted in mice showed no effect on fertility in the progeny of treated dams.

Pain and the Reward Pathway: Preclinical Studies on the Impact of Pain on Opioid - Seeking Behavior Learn about the functional relationship between pain, opioid receptor dysregulation, and motivated and affective behavior, providing new insights into the critical neurochemical and neuroanatomical mechanisms that underlie pain - induced changes in opioid reward and comorbid affective disorders.