Sentences with phrase «on protein design»

Daniels» skill set attracted the notice of Novartis, and in 2008 he joined a group in the Cardiovascular and Metabolic Disease department working on protein design for protein therapeutics.

Not exact matches

In December, Tehrani signed a deal with GlaxoSmithKline that will allow the pharmaceutical giant to test at least four of its drug candidates on a Zymeworks - designed platform, which combines a computer simulation with a way of engineering protein molecules and allows products to be refined before they move to expensive clinical trials.

«While a handful of groups worldwide are developing artificial enzymes, they use rational design to construct the proteins on computers.

The ready - to - cook sausage - made with pea protein isolate, fava bean protein, rice protein, potato starch, coconut oil and beet juice - is designed to «deliver on the juicy, satisfying taste and texture of pork sausage, but with more protein, 43 % less total fat, 38 % less saturated fat, 27 % less calories and 26 % less sodium than traditional pork sausage.»

Heat, acid and mechanical action can all be placed on a protein during any number of manufacturing procedures designed to create protein powders and protein - rich foods.

The new packaging design, which features a green top, will debut on the company's Rockin» Protein fortified milk line (renamed from Rockin» Refuel) and its Cold Brew Coffee and Milk products.

With Gerber stages, the baby food's nutrient contents are designed accordingly with the focus on the following nutrients: protein, fat, carbohydrates, vitamins, minerals, phytonutrients and antioxidants.

RHPs are composed of four types of monomer subunits, each with chemical properties designed to interact with chemical patches on the surface of proteins of interest.

The key technological innovation that enabled this achievement was the use of monobodies - small, synthetic proteins that can be custom - designed to bind to highly specific locations on target proteins.

The first, called bio-bar-code assays, relies on nanoparticles designed to attach themselves to specific disease - causing proteins; these will vastly improve a doctor's ability to detect diseases like cancer and Alzheimer's in their early stages and to identify pathogens like anthrax.

To improve on this result, the researchers used recombinant DNA techniques to generate purified recombinant proteins from the designed multiepitope DNA strings, and gave the mice a series of protein booster shots to increase their immune response.

These insights are intriguing on their own, but when the scientists examined the structure of the nanosheets» backbone, they were surprised to see a design rule not found in the field of protein structural biology.

At the start, researchers pinned their hopes on vaccines designed to trigger production of antibodies against HIV's surface protein.

The researchers targeted mTOR with an experimental drug based on a prototype first designed by Shokat, a chemist and an expert in designing molecules to target this type of protein, called a kinase.

Jacobs and colleagues took pictures of these proteins using x-ray crystallography and NMR, and found that the proteins contained all the unique structural varieties they had designed on the computer.

In further tests, he and his colleagues designed a mutated version of the botulism compound, based on the novel crystal structure, in which HA would not bind with the epithelial cell protein E-cadherin.

Her research centers on engineering the network of proteins that interact with DNA to control the expression of inherited traits (epigenetics) with the aim of rationally designing new biological systems with predictable, reliable behavior, and replacing «magic bullet medicine» with «smart medicine.»

Designed by researchers at Sangamo Biosciences, the drug uses a natural protein that turns on the patient's own gene for helping nerve growth.

For the study, Dr. Dadachova's team paired the monoclonal antibody (mAb2556) designed to target a protein expressed on the surface of HIV - infected cells with the radionuclide Bismuth - 213.

Currently, seasonal flu vaccines are designed to induce high levels of protective antibodies against hemagglutinin (HA), a protein found on the surface of the influenza virus that enables the virus to enter a human cell and initiate infection.

Proteins can be designed that bind to specific patches on target proteins to alter their subsequent interProteins can be designed that bind to specific patches on target proteins to alter their subsequent interproteins to alter their subsequent interactions.

Designed «staple proteins» based on TAL effectors are the key to the method.

This research on these protein clusters, or aggregates as scientists call them, could help guide design of new anticancer drugs.

The researchers then developed a molecule referred to as RK - 33 that was designed to disrupt DDX3's function by locking on to a portion of the protein.

In this case, both teams designed their antibodies to clasp an HIV protein and CD3, a receptor found on the surface of white blood cells.

Traditional methods for sorting cells rely on fluorescent molecular tags, designed to stick to the surface proteins present on certain types of cells but not on others.

The engineered cells contain an antibody - like protein known as a chimeric antigen receptor (CAR), which is designed to bind to a protein called CD19 found on the surface of B cells, including the cancerous B cells that characterize several types of leukemia.

This week, another team of scientists led by Ben Feringa of the University of Groningen in the Netherlands presents a light - activated nanovalve design based on a larger, 3 - nanometer - wide Escherichia coli protein channel.

The modified T cells contain a protein known as a chimeric antigen receptor (CAR), which is designed to target the CD19 protein found on the surface of B cells, including the cancerous B cells that characterize several types of leukemia and lymphoma.

The findings suggest that reductions in the number of cartilage - producing cells, and greater risk for osteoarthritis, may be driven not just by lower adenosine levels but also by lower levels of the protein on the surface of chondrocytes designed to receive and pass on adenosine's signal.

Their findings, reported in the May 19 issue of the journal PLOS ONE, shed light on how the global caterpillar pest called pink bollworm overcomes biotech cotton, which was designed to make an insect - killing bacterial protein called Bt toxin.

«The fact that the field has successfully bioengineered antibodies to oversee the removal of TNF - a suggests that we can design other antibodies to remove spleen - derived immune cell subsets, or the proteins issuing from failing hearts that turn them on,» Prabhu added.

Using a novel method — design - based stereology — which enabled researchers to estimate the volume of the liver and the total numbers and sizes of its cells in 3D, it was found that the liver of mice on a low protein diet had decreased by 65 %.

These proteins can be designed to latch on to the DNA in faulty mitochondria and target them for destruction.

Vaquer designed experiments to test the behavior of drugs in microgravity during his spare time, while he was working in the lab of pharmacologist Rafael de la Torre at IMIM, focusing on a family of membrane proteins called ABC transporters.

Professor Laura Cipolla, from the Department of Biotechnology and Biosciences at the University of Milano - Bicocca, added: «Based on our background on the chemical modification of bio - and nanostructured materials, proteins, and carbohydrates, we designed a new chemical approach in order to force the organic component polycaprolactone to stay together in a stable way with the inorganic component silica.»

The researchers designed a modification in the chemistry of the ProCA32 MRI contrast agent so detectable metals form a bond with calcium molecules on proteins specific to liver tumor tissue.

A dietitian designed a diet that met each study participant's daily energy need and 750 calories in fats and carbohydrates were trimmed per day while maintaining the protein amount based on whether they were in the higher - or normal - protein group.

Particular emphasis is placed on virtual screening, de novo design, evaluation of drug - likeness, and advanced methods for determining protein - ligand binding.

The antibody mimics are based on protein scaffolds that are smaller than antibodies but still maintain structural diversity and can be designed to target different proteins inside a cell.

The work should be significant for pharmaceutical companies that design drugs through painstaking processes and at great cost by eliminating some of the trial and error in identifying new sites on proteins that could be more easily manipulated to treat disease, said Rice biological physicist José Onuchic.

Using this technique, the scientists have designed proteins that latch on to a flu protein and weaken the virus when it infects mice and ferrets.

An exciting development in rational anticancer drug design is Gleevac, a drug that acts on a protein unique to the defective white blood cells in chronic myelogenous leukemia and on a related protein in a rare form of gastrointestinal cancer.

Typically, evidence that disease activity is truly «on - target» with respect to the proposed mechanism can only be examined once appropriate, highly selective chemical tools have been designed, synthesized and iteratively modified by teams of Medicinal Chemists and biologists working with the studied protein.

Near - atomic cryo - EM imaging of a small protein displayed on a designed scaffolding system, Proceedings of the National Academy of Sciences (2018).

Oligonucleotide probes (60 - mers) were designed based on approximately 12,000 genes predicted to encode proteins retrieved from a recent de novo assembly of 454 - sequenced EST libraries of S. pistillata (Karako - Lampert et al., 2014).

Our current research focuses on the discovery and functional characterization of novel proteins, the rational engineering of proteins with improved functional properties, and de novo design of molecular scaffolds for a variety of biotechnological and biomedical applications.

His research focuses on the long - term goal of designing small molecule therapeutics for prion diseases — fatal neurodegenerative diseases caused by the spread of misfolded proteins across the brain.

To gain information about the designed protein dynamics, Kathryn Burnett and Greg Hura of MBIB performed SAXS on the SIBYLS beamline.

He went on to a postdoctoral position with Dr. Iwao Ojima evaluating anti-tubercular compound series that inhibit the cell division protein FtsZ and screening computationally designed small molecule inhibitors of Botulinum neurotoxin.