Sentences with phrase «on pyramidal neurons»

At hippocampal excitatory synapses on pyramidal neurons the cannabinoid - induced synaptic suppression was reversed by a CB1 - specific antagonist, N -(piperidin -1-yl)-5 -(4 - iodophenyl)-1 -(2,4 - dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (AM251), and was absent in CB1 knock - out mice.

To see what was happening in the brains of these ankyrin - G mutant mice, the researchers analyzed the cell components in inhibitory synapses connecting with pyramidal neurons, finding that two proteins known as GAT1 and GAD67 — responsible for making the neurochemical GABA that dials back nerve impulses — were at much lower levels in the synapses on pyramidal neurons in ankyrin - G mutant mice than in normal mice.

Not exact matches

The team, led by CSHL Professor Z. Josh Huang and including researcher Joshua Gordon, M.D., Ph.D., director of the National Institute of Mental Health, focused on dense crowds of excitatory cells called pyramidal neurons — several hundred of which can connect with a single chandelier cell.

A recent generation of studies of postmortem brain tissue from people with schizophrenia, particularly from the laboratory of Professor David Lewis and his colleagues at the University of Pittsburgh, have shed light on schizophrenia - related abnormalities in the interplay of the main excitatory neurons, pyramidal neurons, and a specific class of inhibitory nerve cells, called chandelier cells, in the prefrontal cortex.

It is a complex, highly organised, structure, whose function relies on vast networks containing two main groups of nerve cells, or neurons: pyramidal neurons and interneurons.

Neurons communicate with each other through chemical and electrical signals that can be excitatory (activating) or inhibitory (deactivating), depending on their class: Pyramidal cells are excitatory neurons whilst interneurons are inhiNeurons communicate with each other through chemical and electrical signals that can be excitatory (activating) or inhibitory (deactivating), depending on their class: Pyramidal cells are excitatory neurons whilst interneurons are inhineurons whilst interneurons are inhibitory.

Similar compelling evidence supporting the existence of bonafide intraneuronal Aβ peptides has been provided by ELISA analysis on laser microdissected pyramidal neurons from sporadic AD cases [63].

Effects of sub-threshold activated ion channels on signal integration in hippocampal pyramidal neurons