Sentences with phrase «on results of the current study»

Based on results of the current study described in a report online June 18 in the journal Cancer Cell, Johns Hopkins researchers say they are planning a phase I clinical trial to test the paclitaxel - fostamatinib combination therapy in patients with recurrent advanced ovarian cancer.

Not exact matches

Leadership development consultants Jack Zenger and Joseph Folkman published the results of a study they conducted on the skills that leaders need to succeed in their current positions.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Modern Trends in World Religions, edited by Joseph M. Kitagawa, is not a systematic introduction to world religions but is useful as a general introduction for it is a collection of essays on current trends and problems in the study of world religions as seen by competent scholars who have been reflecting on the results of their research.

As representatives of the minimalists I will consider Edward Schillebeeckx's Jesus: An Experiment in Christology (Crossroad Publishing Co., 1979), a long and weighty study of current New Testament scholarship, and Thomas Sheehan's The First Coming: How the Kingdom of God Became Christianity (Random House, 1986), a more accessible argument based on the results of Schillebeeckx and a number of others.

Previous studies of the effect of breastfeeding on morbidity among full - term infants have not always accounted for selection bias that may result if infants who are breastfed are inherently healthier than bottle - fed infants.22 In the current study, the VLBW infants» ability to breastfeed did not reflect better health status as both human milk and infant formula were provided via gavage feeding especially during early enteral feedings.

Although professional lactation support can improve the duration of overall breast feeding, its effect in improving exclusive breast feeding is unclear.11 18 22 Thus far, studies that report improvement of rates of exclusive breastfeeding have involved mainly community based peer counselling strategies.23 24 25 Even then, a randomised trial in the UK recently cast doubt on the efficacy of this approach.26 There are current recommendations from NICE for the UK - wide implementation of the baby friendly initiative.4 5 6 The 2006 NICE costing report on routine postnatal care of women and their babies estimates that efforts to improve rates of breast feeding will result in substantial cost savings for the NHS.6

With the results of the current study in hand, Snyder has brokered a deal between that company and the National Institute on Drug Abuse (NIDA) for NIDA to test CGP3466B as a treatment for cocaine addiction.

While many previous studies predicted a future increase in humus levels as a result of climate change, based on their current findings, the TUM scientists are critical of this assumption: If the input of organic matter stagnates, soil will lose some of its humus in the long term.

High content of long - chain omega - 3 polyunsaturated fatty acids in blood is a marker for high intake of fatty fish, so the results from the current study support the beneficial effects of fish consumption on brain health.

Based on the results of a pilot study at MGH that evaluated doses as high as 40 grams, participants in the current study received doses of up to 30 grams daily.

«Our study, which is the largest study to date examining the topic of single sports specialization, provides a foundation for understanding current trends in specialization in youth sports,» said researcher, Patrick S. Buckley, MD of the Rothman Institute at Thomas Jefferson University Hospital in Philadelphia, PA. «Our results noted that current high school athletes specialized, on average, two years earlier than current collegiate and professional athletes.

Based on the results of this study, the MHGfC developed new formal guidelines for resident / supervisor communications that were put in place for the current academic year.

Commenting on the results, Professor Johan Vansteenkiste, Professor of Medicine, Catholic University Leuven, and Chief Oncology Physician, Unit of Respiratory Oncology, University Hospital KU Leuven, Belgium, said: «This study may change current practice for the treatment of patients with advanced NSCLC.

Based on the current study results, the team believes a particular enzyme, «dual specificity tyrosine - regulated kinase - 1a (DYRK1A),» is the likely target of harmine.

«Results from this study are based on current climate projections, and it doesn't necessarily mean that lesser prairie - chickens will experience a population decline,» said Blake Grisham, Texas Tech University scientist and lead author of the study.

«The results of our current study support the report on emerging roles of tRFs to viral infections,» the researchers say.

The bill also puts a roadblock in NIH's controversial plan to revamp how pregnant women will be recruited for the study: NIH can make «no changes to the current design or Vanguard pilot structure until at least 90 days after the IOM [Institute of Medicine] conducts a review of the proposed changes and impact on the results.»

The current study is analyzing the results of a Centers for Medicare and Medicaid Services (CMS) Innovation Challenge grant to determine the effects of the intervention on nearly 1,000 early, moderate and late preterm infants, with a goal of improving care, improving outcomes, and decreasing costs.

The study concludes that the growth of the Mauna Kea glacier caused by the AMOC current changes was a result of both colder conditions and a huge increase of precipitation on Mauna Kea — triple that of the present — that scientists believe may have been caused by more frequent cyclonic storm events hitting the Hawaiian Islands from the north.

Table 1: Selection, Design & Construction of HSV - based Oncolytic Viruses Table 2: Selection, Design & Construction of Adenovirus - based Oncolytic Viruses Table 3: Selection, Design & Construction of Vaccinia Virus - based Oncolytic Viruses Table 4: Selection, Design & Construction of Vesicular Stomatitis Virus - based Oncolytic Viruses Table 5: Selection, Design & Construction of Newcastle Disease Virus - based Oncolytic Viruses Table 6: Selection, Design & Construction of Various Virus - based Oncolytic Viruses Table 7: Current Company - Sponsored Clinical Trials of T - Vec Table 8: Clinical Trials of ColoAd1 Table 9: Clinical Trials with JX - 594 Table 10: Clinical Trials with GL - ONC1 Table 11: Clinical Trials of CAVATAK (CVA21) Table 12: Clinical Trials with MV - NIS Table 13: Overview of Oncolytic Viruses by Development Phase & Virus Family Table 14: Profile of Approved and Marketed Oncolytic Viruses Table 15: Pivotal Study Design of Oncolytic Viruses in Late Stage Development Based on Previous Clinical Results Table 16: Approved Indications of Immune Checkpoint Inhibitors Table 17: Active Clinical Studies of Oncolytic Viruses in Combination with Immune Checkpoint Inhibitors (ICI) Table 18: Planned Clinical Studies of Oncolytic Viruses in Combination with Immune Checkpoint Inhibitors (ICI) Table 19: Active or Planned Clinical Studies of Oncolytic Viruses in Combination with Other Anti-Cancer Therapeutics Table 20: Pattern of Transgenes in Oncolytic Viruses in Relation to Development Phase Tables 21a and 21b: Indications and Frquency and Way of Administration of Oncolytic Viruses in Active and / or Positive Completed Clinical Studies Table 22: Small and Medium Pharma & Biotech as Partner for Regional Co-Development of Oncolytic Viruses Table 23: Immuno - Oncology Portfolio of Major Pharma & Biotech with Interest in Oncolytic Viruses Table 24: Interests of Major Pharma & Biotech in Oncolytic Viruses Table 25: First Generation Oncology Virus Companies and their Sources of Technology Table 26: Second Generation Oncology Virus Companies and their Sources of Technology Table 27: Third Generation Oncology Virus Companies and their Sources of Technology Table 28: Fourth Generation Oncology Virus Companies and their Sources of Technology Table 29: Grants, Credits & Donations Table 30: Financing by Venture Capital, Private Equity and Other Private Placements Table 31: Collaboration & Licensing Agreements Table 32: Companies Listed on Stock Exchange & Offerings Table 33: Mergers & Acquisitions

The results of our study on the conservation of the number of digits provides an important argument in the current controversy on the descent of birds from dinosaurs between developmental biologists and paleontologists.

«The amperometric method [29] is based on measurement of electric current resulting from oxidation of the substance (or the mixture) being studied»

These effects occur independently of muscle oxidative capacity and are associated with increases in fatty acid metabolism in liver... The results from the current study indicate that modest increases in type 2b skeletal muscle mass can have a profound systemic effect on whole - body metabolism and adipose mass.

This most recent study discovered that many psoriasis and psoriatic arthritis patients living in America in particular, are unhappy with their current treatments, and dissatisfaction with the results and unwanted side effects being the two biggest reasons why a large number of psoriasis and psoriatic arthritis patients go untreated or abandon conventional treatment, according to this 2013 study that spanned research based on patients interviewed between 2003 and 2011.

Instead a review of studies headed by Ian C. Monro comes to the following conclusion: «Whereas results in some studies are limited or conflicting, when viewed in its entirety, the current literature supports the safety of isoflavones as typically consumed in diets based on soy or containing soy products [emphasis ours].»

However, the atrogene results of the current study indicate alcohol ingestion does not exert any additional effects on ubiquitin ligase expression after exercise in human skeletal muscle.

The results of that study delivered a searing assessment of the effect that many of the current PD programs have on teacher quality, classroom instruction and student achievement.

The day after the WKCE results were released, current results from an on - going University of Arkansas longitudinal study of the Milwaukee program were released.

The New York Times recently reported on the results of the quarterly Federal Reserve bank study that takes a look at current lending practices.

The results of this study have implications on interpreting future changes to the hydroclimate of Peninsular Florida, such as the influence of climate change and low frequency changes to the Atlantic meridional overturning circulation that comprises of the Loop and the Florida Currents as part of its upper branch.

just means that these investigators have been mislead on the actual skill of the NARCCAP results if they are being used in lieu of reanalyses for current climate, and for impact and policy studies of future climate.

According to estimations based on current studies, well over 1» 000 people die every year as a result of mistakes in Swiss hospitals.

Future studies should follow guidance on the development and evaluation of complex interventions (such as the Medical Research Council's guidance).76 The results of all phases of intervention development also need to be published alongside trial results, as current studies alone do not allow us to fully understand why interventions have not produced expected effects.

The results of this current study suggested that nurses were able to maintain themselves carrying on with their nursing practice by dealing with difficulties as part of the nursing profession.

Home Study Methods for Evaluating Prospective Resource Families: History, Current Challenges, and Promising Approaches Crea, Barth, & Chintapalli Child Welfare, 86 (1), 2007 View Abstract Introduces the SAFE home study process, presents results from expert interviews on the changing processes and purposes of home studies, and explores current challenges for the fStudy Methods for Evaluating Prospective Resource Families: History, Current Challenges, and Promising Approaches Crea, Barth, & Chintapalli Child Welfare, 86 (1), 2007 View Abstract Introduces the SAFE home study process, presents results from expert interviews on the changing processes and purposes of home studies, and explores current challenges for theCurrent Challenges, and Promising Approaches Crea, Barth, & Chintapalli Child Welfare, 86 (1), 2007 View Abstract Introduces the SAFE home study process, presents results from expert interviews on the changing processes and purposes of home studies, and explores current challenges for the fstudy process, presents results from expert interviews on the changing processes and purposes of home studies, and explores current challenges for thecurrent challenges for the field.

The size of the CfC impacts on most outcomes was small, but can be considered positive relative to what was observed in the early phase of the UK Sure Start evaluation.3 The current results are also comparable in size to those found in the later impact evaluation of the Sure Start programme, in which 3 - year - old children were exposed to mature SSLP throughout their entire lives.4 Reviews of the effectiveness of early childhood interventions have found that most studies reported effect sizes on parenting and child outcomes that were small to moderate.14 15 When comparing CfC and SSLP with other interventions, it is important to remember that the evaluations of these interventions measured effects on an entire population, rather than on programme participants, as is the case in the evaluation of many other interventions.

This paper: presents current research on the types of interventions used with parents whose children are receiving treatment, with a particular focus on group therapy for parents; reviews the current literature on group work with parents whose children are receiving treatment; and presents the results of an exploratory study of the incidence of concurrent group therapy for parents whose children are receiving treatment.

The results of this study reinforce the need for solutions that both reduce education debt levels for future students, and enable current borrowers to make that debt manageable, so they don't have to put the rest of their financial goals on hold.»

Based on the results of its consumer testing and outreach, described in part III above and in the Kleimann Testing Report as well as the results of the Kleimann Quantitative Study Report, the Bureau believes the Loan Estimate is easier for consumers to use and understand than current Federal disclosures.