Sentences with phrase «on ribosomes»

Walter isolated the six building blocks of the apparatus and dubbed it the signal recognition particle; by the early 1980s, he had demonstrated that the apparatus recruits ribosomes to the ER, latches onto address tags on proteins minted on ribosomes, and transfers proteins to the interior of the ER.

For mRNAs landing on ribosomes, the ribosome displaces the mRNAs» green fluorescent protein.

This leads to degradation of «viral» RNA, preventing its translation on ribosomes into a protein encoded by it, thereby reducing the viral gene expression,» says one of the main co-authors of the research Alexander Timin, a JRF of the Novel Dosage Laboratory at Tomsk RASA Center.

To do that, the spectinamides bind to a particular site on ribosomes that is not shared by other TB drugs.

This makes me happy: Research on ribosomes by Noller and others has led to the development of novel antibiotics that hold promise for use against drug - resistant bacteria.

Expression of the Escherichia coli tryptophanase operon depends on ribosome stalling during translation of the upstream TnaC leader peptide, a process for which interactions between the TnaC nascent chain and the ribosomal exit tunnel are critical.

Based on the ribosome profiling data, the researchers looked for genes that were being expressed differently in the trained mice, identifying 104 genes in total.

«The bactericidal mechanism of ODLs and the fact that they bind to a site on the ribosome not exploited by any known antibiotic are very strong indicators that ODLs have the potential to treat infections that are unresponsive to other antibiotics,» said Mankin, who is also professor of medicinal chemistry and pharmacognosy.

Not exact matches

This additional dose of ribosomes was passed on in the cells of pollen and ovules to subsequent generations through the non-nuclear part of the cell.

So for a postdoc to want to take this on at that stage was remarkable,» Venki Ramakrishnan, a ribosome researcher at the MRC Laboratory of Molecular Biology in Cambridge, U.K., writes in an e-mail.

«All subsequent structures of the whole ribosome or other [large] subunits have depended on this structure» that Ban produced, «and it was a tour de force,» writes Ramakrishnan, who has never collaborated with Ban.

Ban chose to work on one of the most difficult problems in structural biology: imaging the active site of the ribosome, a site within the large subunit of the ribosome where the bonding of individual amino acids into a protein chain is catalyzed.

Thus RNA self - splicing can occur at a rate sufficient to support gene expression in a prokaryote, despite the likely presence of ribosomes on the nascent RNA.

That was surprising, he explains, because «fibrillarin resides deep within the nucleolus of the host cell... [where it] methylates ribosomal RNA molecules, which then go on to form ribosomes,» but its full function may not be completely understood.

Most studies on the details of this process have focused on the role of the ribosome.

It's fitting that this year's chemistry prize has been awarded to Venkatraman Ramakrishnan, who used the institute's # 95 million Swiss Light Source for his prize - winning studies on the structure of the ribosome.

The protein assembly line consists of microtubules that serve as train tracks on which the raw materials — including messenger RNA (mRNA)-- are carried to the protein - making machinery, called ribosomes.

Sofar, studies have focused on how the RQC recognizes and clears blocked ribosomes in the cytosol.

«Among other things, the ribosome is an expensive machine that the cell has invested a lot of energy in making, and now it's stuck on an mRNA.

If the yeast's ribosomes jammed on the oxidized mRNA but were rescued by no - go decay, very little damaged mRNA would accumulate in the cell.

They then separated the cells into two groups — those containing mRNAs associated with ribosomes on the endoplasmic reticulum, and those containing mRNAs associated with free - floating ribosomes in the neighboring fluid - filled space known as the cytosol.

The image highlighted on the cover of Science on 17 June is a typographic illustration, showing ribosome «trains» that travel down a track filled with signals.

No prior life on earth — either evolved in the wild or made by scientists in the laboratory — is known to have ever had or lived with such a tied - up ribosome.

This typical, casual canteen chat only partly reveals the facility's successful lab culture, which encouraged Ramakrishnan to focus on understanding the ribosome, the cellular machinery that turns RNA into protein.

A better understanding of the molecular mechanism of protein biosynthesis depends on the availability of a reliable model for the ribosome particle.

In an era of free love and violent protests, about 100 people danced on the grass, enacting one of the greatest discoveries of the century: how the ribosome translates genes from DNA into proteins.

Preliminary safety testing on cells grown in the laboratory showed the drugs were not toxic to mammalian cells because they only inhibit the bacterial ribosomes and not mammalian ribosomes.

However if the ribosome skipped the hairpin and recognized the sequence on the other side of the hairpin independently and translated it, that's an indication that the sequence is functioning as an internal ribosomal initiation site.»

Bacterial ribosomes stalled on defective messenger RNAs (mRNAs) are rescued by tmRNA, an ∼ 300 - nucleotide - long molecule that functions as both transfer RNA (tRNA) and mRNA.

Evgeny Sogorin of the Institute of Protein Research in Moscow and his dancing ribosomes won in the chemistry category and the People's Choice Award went to Emmanuelle Alaluf at the Free University of Brussels for a video on the use of an enzyme to improve anti-tumor immune response.

Getting at a mechanism for how DNA sequence could influence protein function, the researchers found that ribosomes density on β - actin RNA is more than a thousand times higher than on γ - actin RNA, and indeed all six actin genes had differences in ribosome density.

That's where translation, the second step in protein synthesis, occurs: the mRNAs attached to ribosomes function as templates on which proteins are constructed.

Using an elaborate ballroom dance, he focused on the mystery of what prevents ribosomes from «jamming up» as they move along RNA strands expressing genes.

While on viable mRNAs UPF1 is removed by the protein factories, the ribosomes, it remains bound to defective mRNAs and recruits additional enzymes that cause the degradation of the mRNA «The protein UPF1 bound to the mRNA acts as an armed trap that only has to be triggered when needed to degrade the defective mRNA,» says Zünd.

The cellular protein factories, the ribosomes, read these information carriers — the mRNAs — based on the genetic code and produce the corresponding proteins.

A targeting vector was designed to insert an internal ribosome entry site (IRES), a Cre recombinase sequence, a polyA sequence, and an frt - flanked neo cassette into the 3» untranslated region (after the translational termination site) of the glutamic acid decarboxylase 2 locus (Gad2) on chromosome 2.

A ribosome looks at the first codon in a messenger RNA strand, finds the right amino acid for that codon, holds it, then looks at the next codon, finds its correct amino acid, stitches it to the first amino acid, then finds the third codon, and so on.

«The limit adopted by biologists is 200 to 250 nanometers on the basis that [the structures] must be large enough to contain a DNA or RNA strand, and have the ribosomes, etc., necessary to carry on metabolism,» says Folk.

The helper complex lets the ribosome translate genetic messages into protein more quickly than the ribosome could on its own.

Andrei Korostelev of the University of Massachusetts Medical School focuses on capturing minute structural changes in ribosomes as they translate RNA into proteins.

To figure out how many species might be living in Lake Whillans, the researchers zeroed in on a gene that codes for a ribosome protein, one of the oldest and most conserved biological structures on Earth.

Based on the degree of variation in this ribosome gene sequence, they estimate that the water contains 3,931 species or groups of species, the team reports today in the journal Nature.

The ribosome has two parts, which bind on either side of the mRNA.

His basic research is focused on understanding how eukaryotic mRNAs recruit ribosomes, how ribosomes subsequently locate initiation codons, and how ribosomes regulate the translation of specific subsets of mRNAs.

Chloramphenicol acts on the protein manufacturing system of bacteria (the cell's ribosomes) yet does not affect mammalian, reptilian, or avian ribosomes.