Sentences with phrase «on rodent studies»

It's fine to make educated guesses based on rodent studies of how something might work in humans.

The finding, based on rodent studies, was published recently in the Journal of the American Chemical Society.

Not exact matches

The study, just published in Science, showed that the creation of what the researchers are calling microtumors can help predict drug effectiveness in cancer patients better than the current standard method of testing the drugs on rodents.

Neuroscientists have over the past decade uncovered evidence, both in rodent and human studies, that parental caregiving, especially in moments of stress, affects children's development not only on the level of hormones and brain chemicals, but even more deeply, on the level of gene expression.

With the support of her rodent - tolerant family, she studied the effects of varying thyroid hormone levels on the physical characteristics of a small rat colony she housed in her living room.

Moreover, recent studies on rodents indicate that the internal clock also affects how the metabolism responds to the intake of carbohydrates or fats, and that certain time frames are more suitable than others for the consumption of a high - carbohydrate or a high - fat diet, seen from a health perspective.

Rattus detentus, a Rodent of Unusual Size: On Manus Island, separated from New Guinea by about 100 miles of ocean, researchers found one of the largest rats known from the Melanesian archipelago, a particularly rich region for rat diversity, according to the April study in the Journal of Mammalogy.

The study focuses on the rodent faunas that inhabited the Iberian Peninsula between 12 and 5 million years ago.

Studying the rodents more carefully, the researchers determined that Clostridia were having a surprising effect on the mouse gut: Acting through certain immune cells, the bacteria helped keep peanut proteins that can cause allergic reactions out of the bloodstream.

Furthermore, a rodent study concurrently examined the effects of mid-puberty or adult alcohol exposure on voluntary alcohol consumption in later life by 20 male Wistar rats.

Astronauts will use the device to study the effects on rodents of extended periods of time spent in microgravity.

Dr Kristensen recommends that an inter-disciplinary approach be taken to address this, «by combining epidemiological data from human studies with more experimental research on models, such as rodents, it may be possible to firmly establish this link and determine how it happens, so that pregnant women in pain can be successfully treated, without risk to their unborn children.»

In this article, Dr David Kristensen and colleagues from Copenhagen University Hospital, review the findings from three individual rodent studies that evaluated the effects of paracetamol taken during pregnancy on the development of the reproductive system in female offspring.

All three groups of mice gained weight during the study, but those in the exercising and shaken groups put on slightly less than the indolent rodents.

In previous studies on rodents, postdoctoral scholar Clemenson and others showed that exploring the environment resulted in the growth of new neurons that became entrenched in the hippocampus» memory circuit and increased neuronal signaling networks.

So I returned to school to get my doctorate and studied the effects of different wavelengths and intensities of light on rodents.

He notes a number of collaborative bird studies by Israeli, Palestinian, and Jordanian scientists and a recent project to use barn owls to catch rodents on Israeli and Palestinian farm.

Based on the new study's findings, S. melilutra's jaws would have been strong enough to crush the shells of big mollusks or the bones of birds and small mammals like rodents, though what exactly it ate is unknown.

Studies of germ - free rodents and other animals on gut - disrupting antibiotics show that changing microbial communities can impair memory and cause anxiety - like behaviours.

The cortex is the thin layer of cells on the surface of the brain that governs many functions, and in elephants it contains a greater variety of cell types (such as the extensively branched neuron pictured above) than is found in more frequently studied animals such as rodents and primates.

The basics of glycogen biology are thought to be well established, but a study in rodents published July 5th in the journal Cell Metabolism turns long - standing assumptions on their head.

But the authors of a new study on dying rats make a bold claim: After cardiac arrest, the rodents» brains enter a state similar to heightened consciousness in humans.

Determination of toxicity and side effects; first studies on animals (rodents and nonrodents) that may lead to the leading structure.

«This study entertains the possibility that probiotic treatment can be beneficial in «restoring» certain behaviours in autism and other neurodevelopmental conditions, based on experimental evidence in rodents.

PNP Therapeutics, Inc. — a company based on a gene - therapy technology developed by scientists at Southern Research Institute and the University of Alabama at Birmingham (UAB)-- has found an approach that has abolished otherwise unmanageable human cancers in preclinical rodent studies.

Last April, at a conference resort next to the Golden Gate Bridge, 52 scientists from around the world spent three days doing case studies on: 1) wildlife diseases with vectors such as mosquitoes, 2) wildlife diseases without vectors, such as chytrid fungus in amphibians, 3) destructive island invasives such as rodents and ants.

He spent his basic research career studying the mechanisms of steroid hormone action on the brain, behavior, and mental health, and the influences of the environment and stressors on those actions in laboratory rodents.

During this time, I have been actively engaged in clinical studies of participants that have been diagnosed with glaucoma or high - risk ocular hypertension, as well as in laboratory - based studies on experimental glaucoma models in rodents and non-human primates.

Laboratory Animals publish this month a paper summarising the findings of an NC3Rs expert working group who have been investigating the impact of rodent age on study outcomes.

In a 2005 study, published by the journal Neuron, she and her advisor John Marshall at UC Irvine showed that when given a choice between two separate rat - sized rooms, the rodents preferred the one where they remembered getting cocaine on previous days.

I encourage you to read the full CRUK Science Update Blog post «High - impact science: Hedgehogs, flies and skin cancer — the story of vismodegib», it's an excellent example of how research on flies, rodents and a range of other organisms combined with studies of cancer genetics in humans to enabled the development of an innovative therapy.

However, a new study published in the journal PNAS on Jan. 15 suggests that the maligned rodents were not the culprits.

The current findings are «another piece of evidence that what we see in laboratory rodents on caloric restriction translates to humans,» said Richard Weindruch, PhD, of the University of Wisconsin — Madison, who has studied caloric restriction since 1975 but did not participate in Floel's study.

Eating onions to increase testosterone levels may seem like a joke, but in a study that was conducted on rodents by Iranian scientists it was shown that onions can increase testosterone levels in rodents as high as 300 percent.

Studies done on rodents have shown that when you are binging on sugary foods dopamine levels increase instead of experiencing a gradual decrease.

After three weeks of IER however, a separate study noted a reduction in fat - mass, which suggests that unlike in the rodent studies mentioned previously, humans may be unable to fully compensate for energy deficits incurred on fast days with increasing durations.

Studies in rodents have additionally described post-treatment elevations in the rate of fatty acid oxidation within both the liver and skeletal muscle of mice maintained on IER (100 % ER / alternate days).13 In a comparison of CER (40 % ER / day) and IER (100 % ER / alternate days), the authors of this 20 - week study noted a doubling in the Î ² - hydroxybutyrate levels (a marker of mitochondrial fatty acid oxidation) in IER - fed mice which was not present in the CER group.15 Both IER and CER interventions led to comparable reductions in fasting levels of glucose and insulin.

Current evidence from studies in rodents and humans demonstrates that IER (50 - 100 % ER on restricted days) is capable of promoting weight - loss and / or favourably influencing an array of cardiometabolic health indices, with equal or greater efficacy than CER.

Several trials have demonstrated that the cardiomyocytes of rodents maintained on IER become more resilient to ischaemic injury induced by occlusion of the left coronary artery 18, 21, 29, which translated into improved long - term survival following such injury in one study.21 In addition, within these studies, associations have been found between the cardiovascular improvements and markers of oxidative stress 24, 30, inflammatory responses 18, 24, 29, 30 and increases in circulating levels of adiponectin.29 Collectively, these reported changes in biochemical and physiological cardiovascular risk factors would be expected to suppress atherosclerotic development and preserve cardiovascular health.

I find that troubling when you consider the vast majority of scientific studies examing health effects is undertaken on rodents due to their similarity to humans.

Studies using female rodents, on the other hand, have shown that the subjects stop ovulating and menstruating when put on intermittent fasting.

What do you think of these studies, where rats on 45 % to 67 % sucrose + nutritious diets are reported as fine (in contrast to modern rodents which are fed deficient / purified diets)?

Some of the confusion stems from the fact that the vast majority of studies that initially hinted at potentially harmful effects were conducted on rodents, using dosages well beyond what the average person consumes in a life time.

Four rodent studies that examined the effect of alternate - day fasting on cardiovascular disease were included.

To date many research studies are done after three weeks on the ketogenic diet, based loosely on published anticonvulsant effects in rodents.

To further explore the relevance of these findings in rodents on primate health, a study was initiated at the Wisconsin National Primate Research Center (WNPRC) in 1989, studying a 30 % calorie restriction in rhesus monkeys (8).

While the recent research dealt with rodents, an earlier study examining the effect of turmeric on Alzheimer's patients produced equally promising results.

For instance, marijuana has been shown to suppress the hypothalamic - pituitary axis (HPA) in rodents, but human studies suggest variable effects on the HPA axis.

The concept that plant protein was inferior to animal protein arose from studies performed on rodents more than a century ago.

Three animal studies from Allen Taylor and his colleagues at Tufts University compared the effects of resistant starch versus highly digestible starch on eye health in rodent models.