Sentences with phrase «on signaling cascades»

Her research focuses on the signaling cascades underlying neural circuit connections during brain development, to understand how sensory experiences affect neural circuit wiring, and to identify novel factors required to maintain the health of neural circuits during aging.

It is not unlikely that the combined action of all those phytochemicals at different points on the signaling cascade excert a synergistic inhibitory effect.

Not exact matches

When they react to external stimuli, by binding molecules, for example, a structural transformation takes place on the inside that triggers a signalling cascade (see 2012 Nobel Prize in Chemistry).

Bohn noted isoquinolinone 2.1 is one example of a new class of «biased» kappa agonists that avoid many central nervous system side effects by preferentially activating a G protein - mediated signaling cascade without involving another system based on β - arrestin protein interactions.

The anti-apoptotic effect of BES was dependent on the activation of the PI3K / Akt signaling cascade and an increase in brain - derived neurotrophic factor (BDNF) production.

Within this cascade Shp2 turns on different signaling molecules, but turns off the tumor suppressor genes p27 und p53.

La Jolla, CA — The cellular cascade of molecular signals that instructs cells with fatally damaged DNA to self - destruct pivots on the p53 tumor suppressor gene.

Rho family GTPase inhibition reveals opposing effects of mitogen - activated protein kinase kinase / extracellular signal - regulated kinase and Janus kinase / signal transducer and activator of transcription signaling cascades on neuronal survival.

In the past decade we have identified diverse signaling cascades that converge on gephyrin scaffold to regulate its scaffolding property, and in turn GABAergic neurotransmission.

So, as you can see, this insulin signaling cascade, at least on this arm, regulates a number of aspects of metabolism; both carbohydrate and synthesis carbohydrate metabolism, as well as protein synthesis and metabolism.

Based on these sources, we identify 497 genes with possible immune function in Nasonia (Table S1), including 75 encoding effectors (AMPs, proteins in the prophenoloxidase cascade, transferrins, and peroxidases), 96 encoding recognition proteins (including PGRPs, TEPs, Nimrod - like proteins, and numerous lectins), 101 encoding signaling proteins, and 225 encoding proteases or protease inhibitors.

«FKBP51 influences a signaling cascade in muscle tissue, which with excessive calorie intake leads to the development of glucose intolerance, i.e., the key indicator of diabetes type 2,» says Mathias Schmidt, lead researcher on the project.

The notion that a Nanog positive, ICM - like population of high probability self - renewing cells is a developmental ground state is supported by the expansion of this state in the presence of a blockade on the major signalling pathways known to promote ES cell differentiation, the MAP kinase / ERK cascade and GSK3β [42], [50].

Like in the Wnt signaling pathway, ligands bind to the EGFR on the cell surface and initiate a cascade of events in the cell that in this case lead to regulation of genes that control cell cycle progression.

External cues act on tyrosine kinase proteins embedded in the cell membrane to induce a cascade of signals with a vital role in regulating cell proliferation.

The insulin receptor signaling cascade is inhibited by several phosphatases, including protein tyrosine phosphatase 1B (PTB 1B), phosphatase and tensin homolog on chromosome 10 (PTEN) and SH2 - domain - containing inositol phosphatase (SHIP2), all of which are inactivated by ROS.

In the fasted state these undesirable growth factors that act in a cascading domino fashion on reactant signalling pathways are metabolically inhibited or «dulled» for want of a better expression (at least I tried eh?

Any sweet taste will signal your body that calories are on the way and trigger a cascade of hormonal and metabolic responses to get ready for those calories.