Sentences with phrase «on small molecule drug»

In its inaugural collaboration that focuses on small molecule drug discovery, IACS has signed an exclusive agreement with TESARO, Inc., an oncology - focused biopharmaceutical company.

Not exact matches

SOUTH SAN FRANCISCO, Calif. — February 5, 2018 — FLX Bio, Inc., a biopharmaceutical company focused on the discovery and development of oral small molecule drugs to activate the immune system against cancer, today announced the appointment of senior pharmaceutical research and development executive Michael F. Giordano, M.D., to its Board of Directors.

The Company focuses on discovering and developing small molecule drugs directed against tumor and immune cell targets that control key metabolic pathways in the tumor microenvironment.

The researchers created a new gel, based on small molecules which self - assemble into nanofibers which could interact with a variety of anti-inflammatory, painkiller drugs, including iburofen and naproxen.

In the early 2000s, Danishefsky — who is best known for synthesizing Taxol (paclitaxel), a small - molecule cancer drug derived from the Pacific yew tree — set his sights on synthesizing EPO that would be identical to that in the body.

Basic research on cancer mechanisms has led to over 40 targeted cancer therapies currently on the market, which take the form of monoclonal antibodies, small molecule drugs, and immunotherapies.

Most drugs on the market today are small molecules, active organic compounds with a structure and weight so minute that they can be ingested and pass more easily through cell membranes.

This will give way to the development of a drug to be used in gene therapy against neurodegenerative diseases based on small molecules which enhance the expression of the gene and / or the use of fragments of the Klotho protein itself.

Anderson and Valerie Grum - Tokars, a junior structural biologist on the team, developed a three - dimensional structure of human p38 MAPK, enabling the chemists to design and synthesize novel drug - like small molecules that would disable it.

«There has been a lot of work on Wnt signaling pathways, for example, so there are a lot of small - molecule drugs that could be tested to trigger a stem cell to mature into a neuron.»

The process of drug discovery has been dominated in recent years by the screening of large libraries of structurally diverse small molecules for effects on target proteins associated with disease.

It is worth noting that «academic drugs» need not be blockbusters and that most life sciences rely heavily on small - molecule effectors (e.g., A23187, phalloidin, or phorbol ester).

In another experiment, a more direct test of druggability, the researchers used a library of small molecules — broadly representing potential drug molecules — to see which could compete with the probe in binding covalently to reactive lysines on human proteins.

SOUTH PLAINFIELD, NJ — December 6, 2007 — PTC Therapeutics, Inc. (PTC), a biopharmaceutical company focused on the discovery, development, and commercialization of small - molecule drugs targeting post-transcriptional control mechanisms, today announced an expanded research collaboration with the Spinal Muscular Atrophy (SMA) Foundation.

The giant firms are counting on this class of drugs to bolster profits that will be hurt by the imminent expiration of patents on many small - molecule blockbusters.

TLC's first project, which is also a pilot project of the TRND program, focuses on repurposing an existing small molecule drug, auranofin, initially approved to treat rheumatoid arthritis in the mid-1980s.

UniChem supports the integration of high - throughput screening data on small molecules with chemical libraries and chemical resources for drug discovery and optimization.

Using the new method, published on July 31, 2017 in Nature Chemistry, the TSRI scientists identified more than 100 human proteins that are likely to be targetable with small molecule, pill - based drugs.

I wish them well on developing (1) an antibody to detect and image glucosepane in animals (2) a small molecule drug or enzyme (catabody) to remove the glucosepane (3) luck in finding a development partner for this hypothetical glucosepane breaker.

He served as Laboratory Director at biotech company, Prosetta Corporation, leading several small molecule drug discovery programs focused on viruses of interest to the United States Department of Defense.

PTC is a biopharmaceutical company focused on the discovery, development and commercialization of orally administered, proprietary, small - molecule drugs that target post-transcriptional control processes.

A feature article in the same issue of Science provides a perspective on this research «The Synthesis Machine: An automatic device that makes small organic molecules could revolutionize drug discovery» (full text courtesy of Burke Lab).)

Because LINGO1 has be shown to have a negative impact on neuronal development and survival, inibiting it with a small molecule drug may provide an effective approach for developing a treatment for the severe forms of essential tremor.

These alternate strategies include using small - molecule drugs that affect RNA metabolism or protein stability, as well as administering modified viruses for therapeutic gene delivery (see «Getting a fix on SMA»).

PTC is a biopharmaceutical company focused on the discovery and development of orally administered, proprietary small - molecule drugs that target post-transcriptional control processes.

It also raises the possibility to interfere with these systems by any means (small molecules, FDA approved marketed drugs) and evaluate the consequences on both neurogenesis and neuroplasticity.

About PTC Therapeutics PTC is a biopharmaceutical company focused on the discovery and development of orally administered, proprietary small molecule drugs that target post-transcriptional control processes.

As reported online in PLoS One on October 3, Hopkins colorectal cancer specialists John Abraham, Ph.D., and Stephen Meltzer, M.D. - working with the notion that small molecules generally make better treatment packages - designed small bits of protein only 10 amino acids long as the foundation for their drugs.

ORIC Pharmaceuticals, Inc. is a small molecule oncology company focused on combating the growing resistance problem to current molecularly targeted drugs.

ORIC is a small molecule oncology company focused on combating the growing resistance problem to current molecularly targeted drugs.

Discovering novel small molecule drug leads depends on the ability to efficiently search chemical diversity.

Its small molecule drug conjugates are actively target receptors that are over-expressed on diseased cells.

It focuses on the development and commercialization of small molecule drugs for the treatment of central nervous system disorders.

ACADIA Pharmaceuticals Inc. is focused on the development and commercialization of small molecule drugs for the treatment of central nervous system disorders.

PTC Therapeutics Inc., is a biopharmaceutical company focused on the discovery and development of orally administered, proprietary small - molecule drugs that target post-transcriptional control processes.

Accomplishments: * Actively consulting on, discovery and development of Antibody Drug Conjugates (ADCs) * Actively consulting on, small molecules process optimization, scale - up and regulatory aspects * Sepsis diagnostic kits (mAb based) business to Asia for development, manuf.