Sentences with phrase «on small molecules»

Our study opens the door for novel modalities of treatment based on small molecules that could cross biological barriers on their own,» said co-corresponding author Joseph F. Arboleda - Velasquez, MD, PhD, assistant scientist at Schepens Eye Research Institute.

UniChem supports the integration of high - throughput screening data on small molecules with chemical libraries and chemical resources for drug discovery and optimization.

While his previous method relied almost entirely on small molecules, it still included a minute amount of genetic manipulation; that is, he often required the use of a single gene to enhance his chemical cocktails.

Herein, we focus on small molecules claimed to be CXCR4 antagonists described in the literature between 2008 and 2012.

This will give way to the development of a drug to be used in gene therapy against neurodegenerative diseases based on small molecules which enhance the expression of the gene and / or the use of fragments of the Klotho protein itself.

Not only are biotech companies loosening pharma's stronghold on small molecules, but pharma is, increasingly, forging biotech research alliances.

The researchers created a new gel, based on small molecules which self - assemble into nanofibers which could interact with a variety of anti-inflammatory, painkiller drugs, including iburofen and naproxen.

The automated synthesis technology has been licensed to REVOLUTION Medicines, Inc., a company that Burke co-founded that focuses on creating new medicines based on small molecules found in nature.

This is believed to be the first study to focus on small molecules associated with this disease.

John Belisle, a microbiologist at Colorado State University in Fort Collins, and his colleagues had previously shown that a testing method based on small molecules related to metabolism could distinguish between early Lyme disease and healthy serum samples.

In his research, Juha Piltti has focused on a small molecule, which causes Rho - kinase inhibition and regulation of specific down - stream protein pathways involved in many physiological processes.

In its inaugural collaboration that focuses on small molecule drug discovery, IACS has signed an exclusive agreement with TESARO, Inc., an oncology - focused biopharmaceutical company.

Once the Vanderbilt small molecule library has been screened for potential modulators of the Y4 receptor, I will use the results to design efficient and accurate descriptors that can be used with artificial neural networks to predict activity at the Y4 receptor based on a small molecule's structural properties.

I'm focused on small molecule screening for those reasons (and happen to think I have a new angle on it), but would like to know if there is a good counter-argument in favor of enzymes to consider.

Not exact matches

On its own, the immune system boasts different molecules that detect harmful intruders, eradicate small infections and work to contain larger outbreaks.

Quantum physics governs the universe on incredibly small scales — including at the level of molecules inside chloroplasts, the structures inside plants where photosynthesis happens.

The company's therapeutic candidates are highly selective sodium ion channel 1.7 (Naᵥ1.7) inhibitors based on naturally occurring small molecules.

• Ribometrix Inc, a Greenville, N.C. - based biotech company focused on developing small molecule modulators of RNA to treat disease, raised $ 7.5 million in seed funding.

Series A investors include 5AM Ventures, Canaan Partners, Celgene, WuXi Healthcare Ventures, Novartis Institute of Biomedical Research, and Alexandria Real Estate Small molecule programs with focus on synthetic lethality and...

BioNTech, which has around 700 employees at sites in Germany — more than any other unlisted biotech firm in Europe — is also working on other cancer - fighting technologies, including antibodies, cell therapies and small molecules.

SOUTH SAN FRANCISCO, Calif. — February 5, 2018 — FLX Bio, Inc., a biopharmaceutical company focused on the discovery and development of oral small molecule drugs to activate the immune system against cancer, today announced the appointment of senior pharmaceutical research and development executive Michael F. Giordano, M.D., to its Board of Directors.

The scientists found a small molecule that blocks a vulnerable site on many Type A influenza viruses that is required for infection.

The Company focuses on discovering and developing small molecule drugs directed against tumor and immune cell targets that control key metabolic pathways in the tumor microenvironment.

For all entities, elementary particles, atoms, molecules, and so on, are organic unities, each integrating into itself organic unities smaller in size with the differences in size being unproblematical between each level, above or below.11

Hitherto, in the eyes of a Science too much accustomed to reconstruct the world on one spatial axis extending in a line from the infinitely small to the infinitely great, the larger molecules of organic chemistry, and still more the living cellular composites, have existed without any defined position, like wandering stars, in the general scheme of cosmic elements.

When you listen to the tapes on how the DNA molecule is stripped apart and how a small ensemble of enzymes goes pirouetting down the spiral staircase in a perfectly orchestrated ballet of replicating agents, it is hard not to think that a cosmic choreographer is responsible for the entire performance.

An argument formally similar to Eigen's quasi-species concept has recently been shown11d to provide a satisfactory account of the occurrence of major structural changes on binding of a small molecule to a specific antibody.

They focused on the p75NTR receptor, a protein which is found on the tips of peripheral neurons and known to bind a small molecule called NGF (for nerve growth factor).

The technology is allowing basic scientists and small companies to generate impressive libraries of molecules, on a scale once reserved for big pharma, and select from them the most useful compounds.

He worked on the organic synthesis of molecules able to recognize and bind with other, smaller molecules, a phenomenon called molecular recognition, which had won Donald J. Cram, Jean - Marie Lehn, and Charles J. Pedersen the Nobel Prize in chemistry in 1987.

Other collaborations that are currently being discussed focus on the development of small molecules that could disrupt «kidney» (Malphigian tubule) function in mosquitoes, on the differences in the ability to transmit disease among various populations of Aedes aegypti and other mosquitoes, and on advances in the surveillance of adult mosquitoes.

In a study involving researchers from the Queensland Brain Institute, scientists have shed light on the role that small molecules called microRNAs play in early brain development.

«We have discovered a small molecule compound that shows a profound and prolonged effect on autism - like social deficits without obvious side effects, while many currently used compounds for treating a variety of psychiatric diseases have failed to exhibit the therapeutic efficacy for this core symptom of autism,» said Zhen Yan, PhD, professor in the Department of Physiology and Biophysics in the Jacobs School of Medicine and Biomedical Sciences at UB, and senior author on the paper.

Quantum physics is usually thought to act on light and particles smaller than molecules.

A prototype metal - free flow battery developed by engineer Michael Aziz and colleagues at Harvard University relies on the electrochemistry of naturally abundant, small organic molecules to store electricity generated from renewable, intermittent energy sources.

And ApoE is bound to fat, so it tends to stick to other molecules in biochemical assays, says Menelas Pangalos, who leads research on small - molecule discovery at AstraZeneca in Macclesfield, UK, and has long had an interest in ApoE.

«Eventually you have to replace those genes with small molecules, with proteins, with whatever,» says Ding, who is working on cellular reprogramming methods that use small molecules, rather than viruses.

«Two big advantages to the small - molecule catalysts we've developed are that they are very general — they can work on many different amino acid and peptide structures — and they are very easy to use.

One way cells turn genes on and off is via small RNA molecules.

The research centres on miRNAs, small molecules that have an important role in turning genes on and off in different parts of the body.

Unlike other techniques that depend on the ability to calculate the nuclear structure from the original data, which works best for small molecules, we only need to know the properties of our electron beam and experimental setup.»

It is thereby possible to see the extent to which the small molecules have to bind together for the clumping effect on the protein to be set off.

Just because a molecule appears to heighten attention in a small study on a couple dozen people doesn't mean it will have any effect if it's mixed into a drink and given to someone at random at an unknown dose.

The researchers then developed a «fingerprint» based on 261 small molecules to differentiate between the two illnesses.

Focusing on antibiotics that have been used to counter infectious disease of humans, Walsh provides an up - to - date analysis of how these small molecules interfere with crucial processes in bacteria.

As one water molecule evaporates through a pore in a leaf, it exerts a small pull on adjacent water molecules, reducing the pressure in the water - conducting cells of the leaf and drawing water from adjacent cells.

Building upon their earlier research on the biology of fat metabolism, Joslin scientists discovered that microRNAs - small RNA molecules that play important roles in regulation in many types of tissue — play a major role in the distribution and determination of fat cells and whole body metabolism.

Micro-RNAs are small molecules that help turn genes on and off.

The researchers succeeded in changing the DNA of the E coli bacteria in such a way that the substance CB [8](a small molecule of two nanometres in size with a namederived from the resemblance of this molecule with a pumpkin of the family of Cucurbitaceae) attaches to a protein on the cell membrane.

A machine in University of Illinois chemistry professor Martin Burke's lab assembles complex small molecules out of simple chemical building blocks, like a 3 - D printer on the molecular level.