Sentences with phrase «on specific cell types»

The co-incidence of these 2 pathologies occurs also in humans suggesting a common pathological mechanism moving across the gut - joint axis, with TNF signals acting on specific cell types directing pathogenesis at two different locations.

The two - part approach netted a set of mutations seen only at relapse that enabled the team to sift and sort leukemic and normal stem cells using tools developed in the Dick lab a few years ago to zero in on specific cell types fated to relapse.

Not exact matches

So research teams began souping up various types of immune cells and even targeting them to specific protein markers on tumors.

The treatment is a type of so - called CAR T - cell therapy — taking a patient's own immune cells, called T cells, genetically manipulating them to attack specific proteins on cancer, and infusing them back into the patient.

According to the American Pregnancy Association, the Rh factor is a specific type of protein on the surface of red blood cells.

The study, published in Nature Communications, builds on previous observations from the same team who found that a specific type of cells regulate antibody production.

«This is exactly the technology you could use to look for epigenomic changes in specific cell types,» says Martienssen, who is also on the International Human Epigenome Consortium's steering committee.

To do so they focused on keratinocytes, a specific type of skin cells with a key role in psoriasis because of their abnormal growth and ability to produce large amounts of inflammation promoting factors.

Most cancer vaccines developed to date have been designed to recognize and attack a specific known molecule — such as a cell - surface receptor — that is likely to be found on cancerous cells in any patient with that type of tumor.

Luster's team hopes to further investigate the characteristics of joints that underlie the critical role of C5a in initiating type III hypersensitivity and whether specific molecules expressed on endothelial cells lining joints play a role in transporting C5a and chemokines from the joint space into adjacent blood vessels.

In a previous related study published in the Journal of Materials Science: Materials in Medicine, the same team of NTU scientists found that fish scale - derived collagen would induce human umbilical vein endothelial cells to express 2.5 times more of a specific type of collagen responsible for blood vessel formation, as compared to endothelial cells cultured on bovine collagen.

This seemingly impossible task led most previous studies to examine randomly selected neurons or focus on a specific type of cell.

Rutgers University scientists have discovered the three - dimensional structure of a gene - specific transcription activation complex, providing the first structural and mechanistic description of the process cells use to turn on, or activate, specific genes in response to changes in cell type, developmental state and environment.

Different GPCRs showed up on different neurons, allowing the scientists to parse specific cell types that might direct particular vagus nerve functions.

This could be done by attaching molecules to the surface of the bots that bind to specific receptors on the outside of certain types of cell.

Each well holds a specific antibody that will bind selectively to one type of cancer cell type, based on genetic markers on its surface.

A defining property of all stem cells is that when they divide into two new cells, they can form both stem cells and differentiated cells (cells on their way to becoming a specific type of tissue).

Most notably, the studies are based on transient transfection of wild - type and mutant gene constructs into cultured cells or into zebrafish embryos and are unlikely to reproduce the specific mutant gene dose that is present in heterozygous mutant cells in FOP patients.

An alternative possibility is that successful propagation of TMAdV may depend on infection of a specific host cell type, such as A549 lung, and not BSC - 1 or PMK kidney cells.

The MIT team is now testing this approach to treat tumors in mice and is also working on ways to deliver the antibodies to specific types of cells.

Now, Professor Martin and colleagues have discovered that in response to specific types of cell damage, Parkin can trigger the self - destruction of «injured» nerve cells by switching on a controlled process of «cellular suicide» called apoptosis.

Researchers from immune biology professor Annette Oxenius's group have now discovered what keeps NK cells from killing off their «colleagues from the other department» of the immune system: healthy CD8 + cells are able to detect the immune messenger substance type 1 interferon, which binds to specific receptors on the surface of these immune cells and thereby conceals their stress.

\ n \ n Unfortunately, the general public seems to be unaware of certain basic facts regarding stem cell research and the media contributes to this by frequently reporting on «stem cell» research and not being more specific as to the type of stem cell research that is producing results.

On the heels of identifying the specific type of cell that gives rise to retinoblastoma, RPB - funded researchers at St. Jude Children's Research Hospital are solving a long - standing mystery about how the eyes of vertebrates develop and how a rare pediatric eye cancer progresses.

On the heels of identifying the specific type of cell that gives rise to retinoblastoma, RPB - funded researchers at St. Jude Children's Research Hospital are solving a long - standing mystery about how the eyes...

They determined that altering the expression level of LIGHT (a specific type of molecule that binds to a receptor site of another cell) and also lymphotoxin (LT) on T cells significantly impacted the cholesterol and triglyceride levels.

Depending on the composition of the viral envelope, viruses exhibit particular patterns of cell tropism, and thus are suited for infecting specific cell types.

With the recent development of transgenic mouse models, which allow labelling and manipulation of specific cell types, more and more emphasis has been placed on the tissue scale: How does the collective behavior of many cells gives rise to the architecture that is characteristic for given kind of tissue?

These elusive, as yet undiscovered genes tend to be expressed at low levels or only in certain cell types, or turned on only during specific developmental stages or growth conditions.

Multiple cell types acquire distinctive «senescent» phenotypes on a cell - type - specific basis, and will require ablation to achieve comprehensive rejuvenation.

Luckily, different cell types tend to have different things on their surfaces, which play particular parts in their specialized roles in the tissue, so it is a matter of identifying and targeting cell - surface markers that are specific to these abnormal cell types.

Following up on findings from a an earlier genome - wide association study (GWAS) of type 2 diabetes (T2D) in Latinos, researchers from the Broad Institute of MIT and Harvard and Massachusetts General Hospital (MGH) traced an association detected in that study to variants in a specific gene, SLC16A11, and uncovered two distinct mechanisms by which those variants disrupt the gene's function in liver cells, possibly contributing to the pathogenesis of T2D.

However, it has been difficult to pinpoint which genetic changes are truly relevant to disease, or in what specific cell types the genetic variation has the largest effect on one's health.

To study the effect of ageing on the ability of CMV - specific CD8 (+) T cells to produce type 1 - and type 2 - cytokines, interferon - gamma - and IL -10-producing, CD8 (+) T cell responses in the presence of CMV peptide antigen were measured in CMV - seropositive old and young donors.

Petrelli A, Tresoldi E, Mfarrej BG, Paganelli A, Spotti D, Caldara R, Secchi A, Battaglia M. Generation of donor - specific T regulatory type 1 (Tr1) cells from patients on dialysis for cell therapy after kidney transplantation.

Moreover, emerging literature indicates that the type I IFN system mediates antiviral immunity in a highly context - specific manner depending on the virus, cell type, and host species.

Likely the choice of specific 2A peptide will ultimately depend on a number of factors such as cell type or experimental conditions.

«One can imagine that the cells are molecularly previewing their developmental options by turning on at low levels cell - type - specific genes, and thereby revealing the developmental potential that they have,» said Singh.

The resulting DNA copy number variation and patterns of chromosome loss and gain are tumor - type specific, suggesting differential selective pressures on the two tumor cell types.

In the different cell types of the body, different protein producing genes are active or inactive, and many medical conditions also depend on altered activity of specific genes.

During development, genes within specific cell types are turned on and off to trigger the necessary expression patterns that create a whole animal.

This is a fundamental process which allows the body to heal and develop specific tissues based on cell type.

Neurotoxins are a specific type of toxin that acts specifically on nerve cells, Aflatoxins are definitely bad things, but they are not neurotoxins.

I admit that I'm not well versed on the function of these specific glycoproteins on your red blood cells, but that's what your type is: it refers to specific glycoproteins found attached to the surface of the red blood cells in your body.

On occasion a specific type of white blood cell, called an eosinophil, is elevated in allergic conditions.

On Houston's Clear Thinkers, Tom Kirkendall ponders the view of cancer as tenaciously persistent and able to regenerate after apparently disappearing — driven by a specific cell type lurking within the cancer that is capable of dormancy, growth and infinite regeneration — a cancer «stem cell» in The Cancer Sleeper cell type lurking within the cancer that is capable of dormancy, growth and infinite regeneration — a cancer «stem cell» in The Cancer Sleeper cell» in The Cancer Sleeper CellCell