That bill, based on one from Rep. Diana DeGette, D - Colo., would have allowed federal dollars to flow toward research
on stem cell lines using embryos left over from in vitro fertilization, slated for disposal and donated by the parents.
After that year, the researchers may continue to work
on any stem cell lines (the isolated populations of stem cells) that they have established.
For while the new NIH guidelines explicitly permit funding for research
on stem cell lines in which human embryos have already been destroyed, they also explicitly forbid funding for research
on stem cell lines that have been produced by SCNT (see section V. part B).
The group urged the creation of two central databases: One
on stem cell lines in use worldwide and one on intellectual property rights so scientists can readily access information.
Not exact matches
In all likelihood, soon after he is sworn in, federal dollars will start flowing toward research
on new embryonic
stem -
cell lines, bringing with it new battles to fight.
Not surprisingly, President Obama received high marks from the journal, largely because his response to the question of whether he would lift Bush's ban
on the federal funding of new embryonic
stem -
cell lines is in
line with the view of most in the scientific community.
In August of last year, President Bush approved the use of federal funds to support research
on a limited number of existing human embryonic
stem cell lines.
He was referring to Intelligent Nutrients, his
line of health and beauty products that meets strict NOP organic standards and focuses
on sourcing ingredients in a way that supports the earth, while pushing the envelope with
stem -
cell science to produce maximum - efficacy products.
He ruled that work
on existing embryonic
stem cell lines derived outside federally funded labs did not violate a ban
on the destruction of embryos.
The year's most prominent science issue, federal support of embryonic
stem cell research, is so controversial that the sons of Ronald Reagan gave dueling speeches at the opposing party conventions; Michael Reagan backs President George W. Bush's policies, including the ban
on funding for research
on new
stem cell lines, while Ron supports Senator John Kerry's promise to lift restrictions.
Congressional supporters of
stem cell research have re-introduced legislation to codify President Barack Obama's 2009 executive order lifting restrictions
on the number of human embryonic
stem cell lines available to federally funded researchers.
Another problem is that in its July 2009 Guidelines
on Human
Stem Cell Research, NIH spelled out specific requirements about embryo donation for newly derived
lines, says Pilar Ossorio, a legal scholar who studies research ethics at the University of Wisconsin Law School.
In yesterday's order, Lamberth wrote that they did not: «The prior [Bush Administration] guidelines, of course, allowed research only
on existing
stem cell lines, foreclosing additional destruction of embryos.»
Studying mice with injuries to the
lining of the stomach, the researchers blocked the animals» ability to call
on stem cells for help in the stomach.
Hamilton announced the newest organ -
on - chip innovation, which recreates an intestinal
lining using patient - derived
stem cells, created through a partnership between Emulate and Cedars - Sinai Board of Governors Regenerative Medicine Institute.
But just how close adult and reprogrammed
stem cells can come to matching the capabilities of embryonic
stem cells has become a contentious question in the debate over whether the federal government should continue funding research
on embryonic
lines.
To see whether cancer
stem cell renewal involves a chain of events similar to that used by embryonic
stem cells, and whether the process was affected by oxygen levels, Semenza and graduate student Chuanzhao Zhang focused their studies
on two human breast cancer
cell lines that responded to low oxygen by ramping up production of the protein ALKBH5, which removes methyl groups from mRNAs.
IGFBP3 binds to a receptor protein
on colonic
stem cells causing their death and, in turn, damaging the intestinal
lining.»
In its comment
on the draft policy, the the International Society for
Stem Cell Research asks NIH to define some «core principles» covering what is ethically acceptable rather than set explicit rules that might exclude «
lines that have been in routine use for the past ten years.»
The researchers have isolated the sesquiterpene lactone damsin from the plant and studied its effect
on cancer
stem cells in three different breast cancer
cell lines.
Part of the trouble is the ingredients: Subtle variations in tissue - culture chemicals and Matrigel, or in different
stem cell lines and how they are grown first in 2 - D culture, can have a big impact
on how the organoids turn out, Novitch says.
On the other hand, the problem is, you know, with embryonic
stem cells, they haven't been able to get
stem cell lines from livestock animals that can proliferate in that way, without just sort of veering up in their own direction and turning into, instead of muscle, turning into brain tissue or bone tissue or something else.
The team used five types of antibiotics — including one used to treat acne (doxycycline)--
on cell lines of eight different types of tumour and found that four of them eradicated the cancer
stem cells in every test.
UPDATE: NIH posted a notice today saying that ongoing research
on previously approved
stem cell lines can continue.
The final guidelines
on research with human embryonic
stem cells issued
on Monday by the National Institutes of Health set out criteria for determining which ES
cell lines can be used in federally funded experiments and give NIH discretion to approve old
lines that don't meet stringent modern ethical requirements.
The bill was put forth to loosen the restrictions Bush placed
on human embryonic
stem cell research
on August 9, 2001, when he banned federal funding for work with any
stem cell line created after that date.
While conservatives in Congress took turns echoing George W. Bush's opposition to destroying human embryos for research, Lensch's colleague Paul Lerou stepped into a small room behind a heavy black curtain to check up
on a
line of nonpresidential embryonic
stem cells.
If the president's philosophy — to restrict federal funding to research
on cell lines created prior to August 9, 2001 — lacks a principled moral basis that amplifies the view that the governmental obstacles imposed
on stem cell research, and the delays they have caused, themselves represent an ethical problem.
In the face of these setbacks, many scientists have focused
on new methods of creating
stem cell lines without destroying embryos.
Alternative
cell lines, such as induced pluripotent
stem cells generated from patient skin
cells, offer a more accurate window
on human biology, he says.
In a statement put
on the Web this morning, NIH reported that all 64
lines «show characteristics of
stem cell morphology» and have undergone several population doublings, and most of them have demonstrated all the protein markers «known to be associated with human embryonic
stem cells.»
Tensions have escalated since August 2001, when President George W. Bush limited publicly funded research
on embryonic
stem cells to already existing
lines.
Hajishengallis, Chavakis and their colleagues identified the protein
on hematopoetic
stem cells with which Del - 1 interacts, the ß3 integrin, perhaps pointing to a target for therapeutic interventions down the
line.
They then went
on to demonstrate that the
stem cell lines originated from the skin
cell donors.
On 9 August, President George W. Bush announced that federal funding of stem cell research is permitted, but only for that on cell lines already established from embryos discarded by fertility clinics by the time of his statemen
On 9 August, President George W. Bush announced that federal funding of
stem cell research is permitted, but only for that
on cell lines already established from embryos discarded by fertility clinics by the time of his statemen
on cell lines already established from embryos discarded by fertility clinics by the time of his statement.
The long - awaited registry of human embryonic
stem cell lines approved by the National Institutes of Health (NIH) went up
on the Web this week.
Paper
on creation of
stem cell line from human blastocyst contains fabricated data, university committee concludes
With so much work needed in studying the nature of
stem cells and using them to study disease processes, therapies based
on ES
cells seem very far down the
line, noted Lorenz Studer of Memorial Sloan - Kettering Cancer Center in New York, who pointed out that so far there have only been two published papers
on therapeutic cloning, both of them in mice.
«I am excited to embark
on this
line of research and look forward to the day when patient - specific
stem cells are utilized to treat people suffering from debilitating injuries and health conditions.»
His executive order allowed funding
on embryonic
stem -
cell lines derived from embryos that had already been destroyed, but excluded funding of research using
stem cells from embryos destroyed after August 9, 2001 (the date of his announced policy).
June 21, 2007: Bush vetoes another DeGette - sponsored bill that would allow research
on all
stem -
cell lines using
cells created for in - vitro fertilization and scheduled to be discarded.
To do so, they started with a human embryonic
stem cell line, which they chemically nudged to become
cells that form what's known as the primitive streak
on the hollow ball of
cells of the early embryo.
NeuroStemcell is focused
on the identification and systematic comparison of progenitor
cell lines with the most favourable characteristics for mesDA and striatal GABAergic neuronal differentiation, generated either directly from human embryonic
stem (ES) cells, from Neural Stem (NS) cells derived from ES cells or fetal brain, from induced Pluripotent Stem (iPS) cells or from in vitro short - term expanded neural progenitors from ventral midbrain grown as neurospheres (VMN, Ventral Midbrain Neurospheres) 4, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animals mod
stem (ES)
cells, from Neural
Stem (NS) cells derived from ES cells or fetal brain, from induced Pluripotent Stem (iPS) cells or from in vitro short - term expanded neural progenitors from ventral midbrain grown as neurospheres (VMN, Ventral Midbrain Neurospheres) 4, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animals mod
Stem (NS)
cells derived from ES
cells or fetal brain, from induced Pluripotent
Stem (iPS) cells or from in vitro short - term expanded neural progenitors from ventral midbrain grown as neurospheres (VMN, Ventral Midbrain Neurospheres) 4, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animals mod
Stem (iPS)
cells or from in vitro short - term expanded neural progenitors from ventral midbrain grown as neurospheres (VMN, Ventral Midbrain Neurospheres) 4, and perform rigorous and systematic testing of the most prominent candidate
cells in appropriate animals models.
To develop protocols for production of transplantable mesDA and striatal GABAergic progenitors from human ES and NS
cell lines, building
on recent developments in
stem cell biology;
$ 1.8 M Supports Cancer Drug Discovery
on Commonly Mutated Gene New Brunswick Patch — April 5, 2016 Behavioral Scientist Shares Insights about FDA's Proposed Rule
on Banning Tanning Bed Use among Minors News-Medical.net - March 19, 2016 Intervention Program Reduces Caregiver Distress during Hospitalization of Pediatric
Stem Cell Transplant Patients News-Medical.net - March 9, 2016 Exploring Genomic Pathways in the Development of Ovarian Cancer GMNews.com - March 2, 2016 Differences in Type of Small Protein may further Elucidate Lung Cancer Risk in African Americans ScienceDaily.com - March 2, 2016 Study Looks at Post-Treatment Resources for Prostate Cancer Patients Transitioning to Survivorship News-Medical.net - February 11, 2016 Drawing the
Line on Tanning Bed Use by Teens ScienceDaily.com - December 21, 2015 What Rutgers Study Uncovered about E-Cigarette Use NJBiz.com - December 9, 2015 Identification of Barrier that Prevents Progression of Benign Kidney Tumors to Malignant Disease MedicalNewsToday.com - November, 24, 2015 What is the Color of the Lung Cancer Ribbon?
My post-doctoral work
on the identification of genes required for normal germ
line development and fertility led to the discovery that the germ
line is exquisitely sensitive to mutations in components of the mitotic spindle that have the potential to lead to aneuploidy — this sensitivity may also extend to embryonic and adult
stem cells.
All the hES and human induced pluripotent
stem cell lines were confirmed to be genetically stable and pluripotent in in vivo and in vitro assays after extensive culturing
on the new substrata.
For more
on human embryonic
stem cells, see Teisha Rowland's «All Things Stem Cell post on «Induced Pluripotent Stem Cells: A New Stem Cell Line with a Long History,» The National Institute of Health's Stem Cell FAQs, or, for a visual explanation of terms used, see All Things Stem Cell's Visual Stem Cell Gloss
stem cells, see Teisha Rowland's «All Things Stem Cell post on «Induced Pluripotent Stem Cells: A New Stem Cell Line with a Long History,» The National Institute of Health's Stem Cell FAQs, or, for a visual explanation of terms used, see All Things Stem Cell's Visual Stem Cell Glos
cells, see Teisha Rowland's «All Things
Stem Cell post on «Induced Pluripotent Stem Cells: A New Stem Cell Line with a Long History,» The National Institute of Health's Stem Cell FAQs, or, for a visual explanation of terms used, see All Things Stem Cell's Visual Stem Cell Gloss
Stem Cell post
on «Induced Pluripotent
Stem Cells: A New Stem Cell Line with a Long History,» The National Institute of Health's Stem Cell FAQs, or, for a visual explanation of terms used, see All Things Stem Cell's Visual Stem Cell Gloss
Stem Cells: A New Stem Cell Line with a Long History,» The National Institute of Health's Stem Cell FAQs, or, for a visual explanation of terms used, see All Things Stem Cell's Visual Stem Cell Glos
Cells: A New
Stem Cell Line with a Long History,» The National Institute of Health's Stem Cell FAQs, or, for a visual explanation of terms used, see All Things Stem Cell's Visual Stem Cell Gloss
Stem Cell Line with a Long History,» The National Institute of Health's
Stem Cell FAQs, or, for a visual explanation of terms used, see All Things Stem Cell's Visual Stem Cell Gloss
Stem Cell FAQs, or, for a visual explanation of terms used, see All Things
Stem Cell's Visual Stem Cell Gloss
Stem Cell's Visual
Stem Cell Gloss
Stem Cell Glossary.
The institutional acronym is followed by information
on the
cell type, indicated by either an i for induced or an e for embryonic pluripotent
stem cell lines, respectively.
STEM CELL HOUSE — A bill lifting restrictions on a certain type of embryonic stem cell research cleared a House committee Monday on a party - line v
STEM CELL HOUSE — A bill lifting restrictions on a certain type of embryonic stem cell research cleared a House committee Monday on a party - line v
CELL HOUSE — A bill lifting restrictions
on a certain type of embryonic
stem cell research cleared a House committee Monday on a party - line v
stem cell research cleared a House committee Monday on a party - line v
cell research cleared a House committee Monday
on a party -
line vote.