Sentences with phrase «on subsequent development»

This project investigated the influence of sub-threshold depressive symptoms in combination with early onset substance use on the subsequent development of mental health problems in young people.

One of these artists was Jasper Johns, who had an enormous impact on the subsequent development of Pop, Minimalism and Conceptual art in the United States and Europe.

I do not mean to say that Soutine's painting depends for appreciation on the subsequent development of a certain phase of abstract art.

«This suggests that even in normal pregnancies, the fetal environment has major effects on subsequent development,» adds fetal physiologist and co-author Peter Gluckman of the University of Auckland.

Eleatism was the metaphysics of timeless Being in its most radical form and, although it has never reappeared in its extreme form, it exerted a lasting influence on the subsequent development of Western thought.

Not exact matches

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

Actual results, including with respect to our targets and prospects, could differ materially due to a number of factors, including the risk that we may not obtain sufficient orders to achieve our targeted revenues; price competition in key markets; the risk that we or our channel partners are not able to develop and expand customer bases and accurately anticipate demand from end customers, which can result in increased inventory and reduced orders as we experience wide fluctuations in supply and demand; the risk that our commercial Lighting Products results will continue to suffer if new issues arise regarding issues related to product quality for this business; the risk that we may experience production difficulties that preclude us from shipping sufficient quantities to meet customer orders or that result in higher production costs and lower margins; our ability to lower costs; the risk that our results will suffer if we are unable to balance fluctuations in customer demand and capacity, including bringing on additional capacity on a timely basis to meet customer demand; the risk that longer manufacturing lead times may cause customers to fulfill their orders with a competitor's products instead; the risk that the economic and political uncertainty caused by the proposed tariffs by the United States on Chinese goods, and any corresponding Chinese tariffs in response, may negatively impact demand for our products; product mix; risks associated with the ramp - up of production of our new products, and our entry into new business channels different from those in which we have historically operated; the risk that customers do not maintain their favorable perception of our brand and products, resulting in lower demand for our products; the risk that our products fail to perform or fail to meet customer requirements or expectations, resulting in significant additional costs, including costs associated with warranty returns or the potential recall of our products; ongoing uncertainty in global economic conditions, infrastructure development or customer demand that could negatively affect product demand, collectability of receivables and other related matters as consumers and businesses may defer purchases or payments, or default on payments; risks resulting from the concentration of our business among few customers, including the risk that customers may reduce or cancel orders or fail to honor purchase commitments; the risk that we are not able to enter into acceptable contractual arrangements with the significant customers of the acquired Infineon RF Power business or otherwise not fully realize anticipated benefits of the transaction; the risk that retail customers may alter promotional pricing, increase promotion of a competitor's products over our products or reduce their inventory levels, all of which could negatively affect product demand; the risk that our investments may experience periods of significant stock price volatility causing us to recognize fair value losses on our investment; the risk posed by managing an increasingly complex supply chain that has the ability to supply a sufficient quantity of raw materials, subsystems and finished products with the required specifications and quality; the risk we may be required to record a significant charge to earnings if our goodwill or amortizable assets become impaired; risks relating to confidential information theft or misuse, including through cyber-attacks or cyber intrusion; our ability to complete development and commercialization of products under development, such as our pipeline of Wolfspeed products, improved LED chips, LED components, and LED lighting products risks related to our multi-year warranty periods for LED lighting products; risks associated with acquisitions, divestitures, joint ventures or investments generally; the rapid development of new technology and competing products that may impair demand or render our products obsolete; the potential lack of customer acceptance for our products; risks associated with ongoing litigation; and other factors discussed in our filings with the Securities and Exchange Commission (SEC), including our report on Form 10 - K for the fiscal year ended June 25, 2017, and subsequent reports filed with the SEC.

Among the factors that could cause actual results to differ materially are the following: (1) worldwide economic, political, and capital markets conditions and other factors beyond the Company's control, including natural and other disasters or climate change affecting the operations of the Company or its customers and suppliers; (2) the Company's credit ratings and its cost of capital; (3) competitive conditions and customer preferences; (4) foreign currency exchange rates and fluctuations in those rates; (5) the timing and market acceptance of new product offerings; (6) the availability and cost of purchased components, compounds, raw materials and energy (including oil and natural gas and their derivatives) due to shortages, increased demand or supply interruptions (including those caused by natural and other disasters and other events); (7) the impact of acquisitions, strategic alliances, divestitures, and other unusual events resulting from portfolio management actions and other evolving business strategies, and possible organizational restructuring; (8) generating fewer productivity improvements than estimated; (9) unanticipated problems or delays with the phased implementation of a global enterprise resource planning (ERP) system, or security breaches and other disruptions to the Company's information technology infrastructure; (10) financial market risks that may affect the Company's funding obligations under defined benefit pension and postretirement plans; and (11) legal proceedings, including significant developments that could occur in the legal and regulatory proceedings described in the Company's Annual Report on Form 10 - K for the year ended Dec. 31, 2017, and any subsequent quarterly reports on Form 10 - Q (the «Reports»).

Focusing exclusively on high - potential products that align with health system priorities and patient needs, EXCITE's pre-market approach identifies opportunities for improvement while products are still in development, resulting in better technologies for patients and lower system costs, while also streamlining the subsequent adoption process.

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

Newman goes on to argue that claiming that faith must always proceed works in living the Christian life is «mistaking a following in order of conception for a following in order of time...» In fact, he writes, our works are «the concomitant development and evidence, and instrumental cause, as well as the subsequent result of faith.»

Consider a partial list of developments since just World War II: a broad national decline in denominational loyalty, changes in ethnic identity as hyphenated Americans enter the third and subsequent generations after immigration, the great explosion in the number of competing secular colleges and universities, the professionalization of academic disciplines with concomitant professional formation of faculty members during graduate education, the dramatic rise in the percentage of the population who seek higher education, the sharp trend toward seeing education largely in vocational and economic terms, the rise in government regulation and financing, the great increase in the complexity and cost of higher education, the development of a more litigious society, the legal end of in loco parentis, an exponential and accelerating growth in human knowledge, and so on.

McGrath is aware of the risk of slipping into Deism - with a creator sitting back and detachedly watching his creation unfurl - hence, his emphasis on the importance of a Trinitarian approach, in which God not only intervenes in the subsequent development of His Creation, but in which the whole Christian economy of salvation is worked out.

By this we do not mean just the temporal development that historical criticism discerns in the redaction of these codes, the evolution of moral ideas that may be traced out from the first Decalogue to the Law of the Covenant, on the one hand, and from the Decalogue itself through the restatements and amplifications of the book of Deuteronomy to the new synthesis of the «Holiness Code» in the book of Leviticus and the legislation subsequent to Ezra, on the other; more important than this development of the content of the Law is the transformation in the relationship between the faithful believer and the Law.

It is my impression that, on the European continent, it is the basis for almost all subsequent philosophical developments.

The funds crunch triggered by things as well as speedy credit score development, the regulatory deposit reserve prerequisite in addition to a crackdown on very hot dough inflows is abating subsequent to the central bank signaled its readiness to appease marketplace volatility.

In 2007, researchers published the first randomized, controlled study of the effect of being raised in an orphanage; that study, and subsequent research on the same sample of Romanian orphans, found that compared with babies placed with a foster family, those who were sent to institutions had lower IQs, slower physical growth, problems with human attachment and differences in functioning in brain areas related to emotional development.

Initially low levels of parental control didn't have a significant effect on a girl's subsequent development of externalizing behavior problems.

«Although intrauterine experiences can exert influence on the infant's subsequent development, the experiences it has during the ten months or so after birth are of greater experience... a continuing symbiotic relation between mother and child designed to endure an unbroken continuum until the infant's brain weight has more than doubled.»

An infant must learn to attach and suckle properly at the breast during the first few days of life to successfully establish breastfeeding.1,, 2 Early oral experiences that require sucking mechanics different from those required for breastfeeding are believed to contribute to the development of improper latch and subsequent breastfeeding failure — a problem described as nipple confusion.2 — 4 The avoidance of pacifiers was included as 1 of 10 steps for successful breastfeeding in the 1990 Innocenti Declaration on maternity services and breastfeeding, and many experts recommend that mothers who are breastfeeding avoid exposing their infants to artificial suckling experiences including use of pacifiers.5 — 7

Given the subsequent development of Conservative euroscepticism, it's not hard to see why that decision now weighs so heavily on Major's mind.

While some complained that his attack on the Cameron - Coulson link was too partisan, subsequent developments have served to at least partially vindicate it.

Tony Crosland who set out on a mission to «destroy every fucking grammar school in England» is served particularly poorly by subsequent developments.

«Unfortunately the Governor's veto and subsequent suspension of the tax incentive program could have a significant impact on local development.

Commenting on the development and subsequent constitution of a three - member committee to probe the impasse at the GCMC, Mr Boateng said on Wednesday 9 May in an interview...

The author discusses the production of Salk vaccine at Cutter Laboratories, the tragic effects of the inadvertent injection of 200,000 people with live virulent polio virus, the subsequent legal proceedings, and the shadow those have cast on the development of new vaccines.

A subsequent project involved the development, dissemination and analysis of a preliminary global questionnaire to elicit the views of scientists, engineers and health professionals as to the meaning of the right; and organization of a briefing for the United Nations Committee on Economic, Social and Cultural Rights to inform its development of a General Comment on the right.

Chemical pollutants, dietary components, temperature changes and other external stressors can indeed have long - lasting effects on development, metabolism and health, and maybe even in subsequent generations.

The results of the Immune Tolerance Network's (ITN) «Learning Early About Peanut» (LEAP), discussed on February 23, 2015 at the American Academy of Allergy, Asthma & Immunology Annual Meeting and published in the New England Journal of Medicine, demonstrate that consumption of a peanut - containing snack by infants who are at high - risk for developing peanut allergy prevents the subsequent development of allergy.

«The findings suggest an effect of birth weight differences on development of subsequent conduct problems,» researchers led by Dr. David Mankuta of Hadassah Hebrew University Hospital in Jerusalem, said in a news release.

Given the importance of early childhood development on subsequent health, there may be knockon effects across the life course.

The program covers the very long path Batman took back to the big screen and related issues, the project's tone and various proposals, Burton's arrival on the flick and its subsequent development.

Two projects based on Wiseman's subsequent books, about mothers and teenage boys, are in development.

Needless to say, this development has a negative effect on their subsequent screen performance which in turn frustrates Sam when he can no longer coax the same chemistry out of his leading man and woman.

Prior to and subsequent to implementing the hybrid - block, there was significant discussion and teacher - driven professional development relating to how the additional time would be used by the teachers and students in order to optimize its positive impact on assessment tests, added Hagen.

The Alabama Best Practices Center (ABPC) ~ a professional development arm of A + Education Partnership ~ was created because its leaders believed there was great potential in forming substantial partnerships with educators at all levels in public education to help inform policy - making on the state level and address disconnects between the intent of policy and subsequent implementation.

Subsequent years and developments The second year project had a focus on poetry, whilst this year the project involves literacy and mathematics.

Much of the research examining how professional development influences teacher practices and subsequent student outcomes has focused on the content and process of effective professional learning.

Any subsequent modification in the professional development team's recommendation to the board of education or BOCES shall be presented to the board of education or BOCES on or before June 1st, and the board of education or BOCES shall act on the plan by June 30th.

Based on theory and the existent research literature, however, there is a growing consensus in the educational community concerning what constitutes high quality professional development that supports educators and subsequent student learning.

The virtual experience focused on the history of Magna Carta and its effect on human rights development in the subsequent centuries.

Since the 2008 Melbourne Declaration on Educational Goals for Young Australians and its subsequent reforms, public and private school teachers have been required to engage with the Australian Professional Standards for Teachers and the Australian Professional Standard for Principals, two documents that articulate a continuum of teacher development from graduate to principal.

Subsequent developments on the vehicle's suspension system have ensured high performance on the road.

However, going from past developments, my money is on Amazon, not only to do well with the Fire but to improve it and give the iPad a run for its money in subsequent generations.

[Mr. Scott] intends to review his investment in [ASYS] on a continuing basis and, depending upon the price and availability of shares of the Common Stock, subsequent developments affecting [ASYS], [ASYS]'s business and prospects, other investment and business opportunities available to [Mr. Scott], general stock market and economic conditions, tax considerations and other factors considered relevant, may decide at any time to increase or to decrease the size of his investment in [ASYS].

Second — The incremental rise in book value subsequent to 2001 include windows when Burwood was considered «under development» and both soft and hard costs plus capitalized interest expenses were incurred and added to Reading's cost basis as Reading first up - zoned (move to «Major Activity Center» status in 2004), then improved (filling in most of the rock quarry) and then environmentally remediating the soil on the site for several million $.

This position saw her come full circle after a volunteer position on the Central Alberta Humane Society Board of Directors in 2001 led to a subsequent career in Fund Development.

In this article, I touch only briefly on the potential link between vaccines and the subsequent development of other serious diseases.

I bring up getting sued as something that went wrong because of the impact the between - publishers transition and subsequent lawsuit had on the development of Brutal Legend.

The controversy surrounding Team Bondi's treatment of their staff and subsequent liquidation can't have helped, but in a chat with IGN, Rockstar Jeronimo Barrera, VP of Product Development, revealed the delay boiled down to the studio wanting to finish all the console DLC first before beginning work on the PC port, which they didn't want to rush.