Sentences with phrase «on surrogate markers»
However, pathophysiological mechanisms behind disrupting actions are mostly based on surrogate markers and not well understood at the moment.
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Cardiovascular phenotyping between the ages of 60 and 64 years with carotid intima media thickness (cIMT; a surrogate marker for cardiovascular events) was used to assess the effect of lifetime exposure to adiposity on cardiovascular risk factors.
These recommendations are based largely on a body of research that links higher sodium intakes to certain «surrogate markers» such as high blood pressure, an established risk factor for heart disease.
«The lack of association between response rates and hard clinical outcomes raises concerns about fast track approval of new drugs, based on results from trials utilizing solely these surrogate markers,» the researchers wrote.