Sentences with phrase «on synaptic changes»
Since 2011, as an associate professor at Stanford University, I have led a team focused on synaptic changes occurring during normal and pathological behaviors (sleep, fragile X syndrome, ASD) as well as eye / brain neuronal regeneration.
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Unexpectedly, these behavioral changes were accompanied by an increase in inhibitory synaptic transmission with no apparent effect on excitatory synapses.
We are particularly interested in an emotional stress - induced change in endocannabinoid signaling and synaptic transmission and the effects of stress on the activity of a neuronal circuitthat is associated with learning / memory (see J. Neurosci.31: 501, 2011, 29:381, 2009; Nature Neurosci.
He is one of the world's leading researchers on synaptic plasticity in the brain and has pioneered new optical methods of observing the structural changes in the living brain as it adapts to its environment.
Synaptic pruning and other changes that occur in the adolescent brain give teenagers the tools to start making decisions on their own — even if they're bad decisions, says Luna.
These changes were region - specific, depended on timing of the separations during the first weeks of the pups» life, and they also found a possible link between synaptic changes and endocrine function.
One final example is the prefrontal cortex, which is thought to play an important role in regulating behavior by suppressing impulses and emotions arising from the amygdala and other parts of the limbic system.50 — 52 In animal studies, exposure to chronic stress or glucocorticoids alters the synaptic connectivity within the prefrontal cortex, 52,53 and this may limit the ability of the prefrontal cortex to (1) suppress the impulsivity and aggression of the limbic system, and (2) execute adaptive responses (rather than maladaptive responses) to stress.54 — 56 Stress - induced changes in brain structure parallel the well - described impact of significant childhood adversity on a variety of brain functions, including the modulation of physiologic responses (hyper - responsive or chronically active stress response), learning (impaired memory), and the regulation of behavior (the ability to execute adaptive vs maladaptive responses to stress).3, 39,57