Sentences with phrase «on synaptic transmission»

We have previously shown ex-vivo its beneficial effect on synaptic transmission and plasticity in a mouse model of the OPHN1 loss of function.Here, we report that chronic treatment in adult mouse with Fasudil, is able to counteract vertical and horizontal hyperactivities, restores recognition memory and limits the brain ventricular dilatation observed in Ophn1 - / y However, deficits in working and spatial memories are partially or not rescued by the treatment.

These results contrast with traditional knockout mice, where compensatory mechanisms mean that knockout of either PDS95 or PDS93 have no effect on synaptic transmission (Elias 2006).

Her research seeks to clarify the protein machinery involved in memory formation and consolidation under normal and pathological conditions, focusing on synaptic transmission and brain plasticity.

Not exact matches

Slow - acting neurotransmitters control the efficacy of fast synaptic transmission by regulating the efficiency of neurotransmitter release from presynaptic terminals and by regulating the efficiency with which fast - acting neurotransmitters produce their effects on postsynaptic receptors.

Nguyen plans on applying IM - LARIAT technology to a living brain, where she would be able to control synaptic vesicle transmission and communication between neurons.

Unexpectedly, these behavioral changes were accompanied by an increase in inhibitory synaptic transmission with no apparent effect on excitatory synapses.

We are particularly interested in an emotional stress - induced change in endocannabinoid signaling and synaptic transmission and the effects of stress on the activity of a neuronal circuitthat is associated with learning / memory (see J. Neurosci.31: 501, 2011, 29:381, 2009; Nature Neurosci.

It really is an uncannily good transmission, with shifts that snap home rapidly but also effortlessly at modest speeds and throttle openings, yet crack home with synaptic immediacy when you're absolutely on it.