Sentences with phrase «on synthetic cell»

They decided to grow the cells on the lung's extracellular architecture rather than on synthetic cell matrices — the approach most researchers have focused on until now.

Not exact matches

The ESRC Genomics Forum has a commitment to promote social research on the contemporary life sciences around issues including designer babies, synthetic blood, DNA profiling, identity politics, personalised medicine, stem cell research and synthetic biology.

Synthetic biology enables researchers to tackle a huge and diverse range of applied problems: building a cell with the smallest possible genome; synthesizing proteins with extra amino acids — more than the 20 found in nature; using bacteria to produce medicines previously too complex to synthesize; even decomposing living organisms into standard, off - the - shelf «biobricks» that can be assembled on demand.

A synthetic product outlasting the typical 42 - day shelf life of red blood cells and sidestepping even the miniscule risk of transmitting a blood - borne disease would also be high on the medical wish list.

«Growing stem cells on synthetic surfaces with different levels of compliance showed that stem cells would become a different cell type depending solely on the mechanical environment they perceive.

The new work is «solid,» says John Dueber, a synthetic biologist at the University of California, Berkeley, who is working on splicing morphine synthesis genes into yeast cells.

At its most basic, synthetic biology is about making DNA from scratch, on scales from individual molecules to cells, tissues and even entire organisms.

«CellNet will also be a powerful tool to advance synthetic biology — to engineer cells for specific medical applications,» says James Collins, PhD, Core Faculty member at the Wyss Institute and the William F. Warren Distinguished Professor at Boston University, co-senior investigator on one of the studies.

I found that culturing cardiac valve cells on synthetic hydrogels preserves their normal properties better than the traditional plastic plates do, and I discovered a signaling pathway connecting the stiffness of the supporting scaffold to the cells» cytoskeletal structure.

The study included 124 newly diagnosed patients at 25 clinical trial sites in the U.S. Two - thirds of the patients were treated with ICT - 107, an experimental vaccine based on immune system cells called dendritic cells that were exposed to six synthetic proteins, or antigens, known to be involved in GBM development.

They built a set of synthetic genes that function in cells like NOR gates, commonly used in electronics, which each take two inputs and only pass on a positive signal if both inputs are negative.

The trick was to use a new synthetic switch to confer light sensitivity on the retinal ganglion cells in these mice, which normally respond to signals from the rods and cones upstream of them.

On - demand replacement body parts inched closer to reality with the announcement from San Diego biotech company Organovo that its organ «printer» had created the first artificial blood vessel made entirely from human cells, with no synthetic scaffolding.

The aim is to make a synthetic skin substitute that is based on biodegradable polymers and peptides which can be reconstituted with the patients own cells.

«This is another great example of how using a synthetic «bottom - up» engineering approach and leveraging the power of biological design — this time at the scale of individual molecules interacting on cell membranes — can lead to breakthrough technologies for medicine that overcome limitations that hold back more conventional approaches,» said Wyss Institute Founding Director Donald Ingber, M.D., Ph.D., who is also the Judah Folkman Professor of Vascular Biology at Harvard Medical School and the Vascular Biology Program at Boston Children's Hospital and Professor of Bioengineering at Harvard's John A. Paulson School of Engineering and Applied Sciences.

Craig Venter and his teams at the J. Craig Venter Institute in Rockville, Maryland, and San Diego, California, have shown themselves to be technical wizards by synthesising a genome from code contained on a computer, and using it to start a cell line of the resulting synthetic organism (see «How the synthetic bacterium was made»).

One of those treatments might someday be based on a synthetic protein fragment that Robert P. Hammer of Louisiana State University has developed to disrupt formation of the plaques believed to provoke massive brain cell death in Alzheimer's patients.

This could let synthetic biologists generate tissues on demand, such as insulin - producing β cells, or cartilage - producing chondrocytes.

Our investigations on human cell lines in the laboratory have shown that synthetic cannabinoids, in the high concentrations found in cells in the oral cavity or in the lungs, for example, are likely to trigger damage to the DNA that may have significant consequences for the consumers of such substances.

His laboratory currently applies high throughput imaging technologies to study trafficking between the endoplasmic reticulum and Golgi complex, and the internalization pathways taken by synthetic nanoparticles on exposure to cells.

«These response behaviors, in two separate species of animals, validate that the cells containing the synthetic gene turn on in a magnetic field,» Wheeler noted.

Ruiz's lab instead used a synthetic chemical to bind to hotspots on MurJ in cells in ways that immediately stopped the protein from functioning.

Typically, this involves creating a «scaffold» of natural or synthetic materials, seeding it with human stem cells that can differentiate themselves into particular tissue types, and providing the cells with nutrients and a physical environment that encourages them to take on the three - dimensional structures and functions of a particular body part.

We are seeking individuals to characterize novel synthetic inhibitors developed by our collaborators in vitro and in cell culture (the latter for effects on peptide hormone / neurotransmitter) synthesis).

Specific activities include optimizing the conduct and oversight of gene transfer research, updating and interpreting biosafety policies under the NIH Guidelines Involving Research with Recombinant and Synthetic Nucleic Acids, providing critical input on governmental policies regarding dual use research, the NIH Stem Cell Registry.

Previously, his group described synthetic Notch receptor on CAR T - cells.

On May 20th of this year, researchers at the J.C. Venter Institute announced the creation of a bacterial cell controlled by a synthesized genome, a significant milestone in the emerging field of synthetic biology.

The research team also created a synthetic version of the virus in a lab and found that toying with Tat completely outside of a host immune cell could also switch it on and off, building on a study published last year which concluded that latency was «hard - wired» into the virus.

Potential therapies targeting this synthetic lethal target will have dramatically reduced toxicity since normal cells do not rely on these genes.

The findings, published online in Cell Reports on Dec. 10, 2015, offer a glimpse into the evolutionary roots of the circadian clock and point to potential applications in synthetic biology.

The latest achievement of J. Craig Venter — rebooting a bacterial cell as a different species by giving it a man - made genetic instruction manual — is just one step on the long inevitable path into synthetic biology.

Professional Duties & Responsibilities Biomedical and biotechnology engineer with background in design of biomaterials, biosensors, drug delivery devices, microfrabrication, and tissue engineering Working knowledge of direct cell writing and rapid prototyping Experience fabricating nanocomposite hydrogel scaffolds Proficient in material analysis, mechanical, biochemical, and morphological testing of synthetic and biological materials Extensive experience in bio-imaging processes and procedures Specialized in mammalian, microbial, and viral cell culture Working knowledge of lab techniques and instruments including electrophoresis, chromatography, microscopy, spectroscopy, PCR, Flow cytometery, protein assay, DNA isolation techniques, polymer synthesis and characterization, and synthetic fiber production Developed strong knowledge of FDA, GLP, GMP, GCP, and GDP regulatory requirements Created biocompatible photocurable hydrogels for cell immobilization Formulated cell friendly prepolymer formulation Performed surface modification of nano - particle fillers to enhance their biocompatibility Evaluated cell and biomaterial interaction, cell growth, and proliferation Designed bench - top experiments and protocols to simulate in vivo situations Designed hydrogel based microfluidic prototypes for cell entrapment and cell culture utilizing computer - aided robotic dispenser Determined various mechanical, morphological, and transport properties of photocured hydrogels using Instron, FTIR, EDX, X-ray diffraction, DSC, TGA, and DMA Assessed biocompatibility of hydrogels and physiology of entrapped cells Evaluated intracellular and extracellular reactions of entrapped cells on spatial and temporal scales using optical, confocal, fluorescence, atomic force, and scanning electron microscopies Designed various biochemical assays Developed thermosensitive PET membranes for transdermal drug delivery application using Gamma radiation induced graft co-polymerization of N - isopropyl acylamide and Acrylic acid Characterized grafted co-polymer using various polymer characterization techniques Manipulated lower critical solution temperature of grafted thermosensitive co-polymer Loaded antibiotic on grafted co-polymer and determined drug release profile with temperature Determined biomechanical and biochemical properties of biological gels isolated from marine organisms Analyzed morphological and mechanical properties of metal coated yarns using SEM and Instron Performed analytical work on pharmaceutical formulations using gas and high performance liquid chromatography Performed market research and analysis for medical textile company Developed and implement comprehensive marketing and sales campaign

United States Air Force (Al Dhafra Air Base, United Arab Emirates) 2008 — 2009 Operations Manager / Resource Advisor • Serve as Programs Flight Chief of the 380th Equipment Maintenance Group responsible for $ 3M budget • Plan, direct, and oversee three operation cells dealing with emergency management • Categorize, prioritize, and communicate all incidents including base attacks, and disasters to the Emergency Operations Cell • Dispatch quick reaction forces and Emergency Response teams to breaches in security and to treat wounded personnel • Negotiate and execute $ 3,000,000 paint contract with three one year renewal options • Perform contract surveillance on paint / mezzanine contract for back shop operations • Establish Indefinite Quantity purchase of aircraft synthetic oil and sole sourced supplies to ensure fleet health • Target high use supply items, forecast consumption rates, and prevent loss of production do to non-availability