Sentences with phrase «on the biomarkers of»

Advances in the understanding of the biological bases of aging enable better assessment of acute effects of salutary interventions on biomarkers of aging.

Lauren A. M. Lebois, PhD, is a cognitive neuroscientist focusing on the biomarkers of trauma - spectrum disorders as an assistant neuroscientist in the laboratory of Kerry J. Ressler, MD, PhD.

Additionally, gluten had no effect on the biomarkers of intestinal inflammation or an immune response, suggesting that gluten may not be the real culprit of intestinal inflammation after all.

This research has centered on biomarkers of inflammation including interleukin - 6 (IL - 6), vascular cell adhesion molecule - 1 (VCAM - 1), and lymphocyte function - associated antigen - 1 (LFA - 1).

This is the first prospective pilot study assessing the epidemiological effects of a yoga intervention on biomarkers of inflammation (CRP, IL6, and TNF) and DNA methylation patterns of the CRP, IL6 and TNF genes, and comparing changes in these biomarkers with self - reported stress, distress and mood in middle - aged women.

Dietary supplementation with trans - 11 - and trans -12-18:1 increases cis - 9, trans -11-conjugated linoleic acid in human immune cells, but without effects on biomarkers of immune function and inflammation

Effect of 6 - month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial.

A few studies have shown that the bioactive components of cruciferous vegetables can have beneficial effects on biomarkers of cancer - related processes in people.

The researchers found that each group rapidly took on the biomarkers of the other, including bacterial activity, fibre fermentation and intestinal inflammation.

Not exact matches

The first is to increase the sensitivity of the sensors they've developed to pick up on the subtle biomarkers.

BiomarkerBase ™ equips busy professionals in research, business development, and marketing roles to easily stay on top of developments in the clinical / commercial use of molecular biomarkers.

In the spring, the U.S. Food and Drug Administration approved an antibody that is the first cancer therapy based on a tumor genetic biomarker instead of a location in the body.

Larger biomarker signatures can be detected with technology from CDI Laboratories, which offers microarrays of functional human proteins (over 20,000 on a single array) to test the antibodies present in human liquid biopsy samples, such as blood, serum, plasma, CSF, or tissue lysates.

The researchers also found that using physiological biomarkers, such as hormones from droppings, is an effective way of evaluating the impact of ecological and demographic factors on animal populations.

For the study, the Johns Hopkins team set out to lower the rate at which doctors order cardiac biomarker testing for the diagnosis of acute coronary syndrome by basing the desired rate on scientific evidence.

This new study of non-military, civilian trauma patients visiting the emergency department builds on recent research conducted by Dr. Samadani, supported through the Cohen Veterans Center, which found that the use of this novel eye - tracking technology could reveal edema, or swelling, in the brain as a potential biomarker for assessing brain function and monitoring recovery in people with head injuries.

Killary said the team is working to use the biomarkers in MD Anderson's high - risk clinic, established through MD Anderson's Pancreatic Cancer Moon Shot ™, part of the institution's Moon Shots Program ™ to accelerate the development of life - saving advances based on scientific discovery.

While the study included a large number of vascular risk factors, no information was available on individual biomarkers, or migraine specifics such as the presence or absence of migraine aura.

But because the new DNA objects are on the same size scale of devices that can be patterned using computer chip lithography, it might be possible to integrate the two technologies and design DNA origami to detect cancer biomarkers and other biological targets that could then be read out by electronic devices, Castro says.

This wide assortment of symptoms has Frankovich on a quest to identify subgroups in the hopes of tailoring treatments, but she longs for the day she can find and use a full array of biomarkers signaling disease and genetic risk.

When Lipkin was interviewed this past November about a 2 - year, $ 766,000 project on CFS / ME funded by NIH, on which he and Hornig are co — principal investigators, Lipkin credited several external collaborators but did not mention Hornig's contribution to the work, which aims to identify biomarkers of CFS / ME.

The biomarker panel, enabled by discovery work of first author Jungsun Kim, PhD, a postdoctoral fellow in Zaret's lab, builds on a first - of - its - kind human - cell model of pancreatic cancer progression the lab described in 2013.

Measurement of four biomarkers associated with a water - only diet suggested that the diet has the same physiological effects on the body as more extreme fasting.

Dubbed the «lab - on - a-chip,» the device promises faster result times, reduced costs, minimal sample demands and better sensitivity of analysis when compared with the conventional bench - top instruments now used to examine the tiny biomarkers.

Many cancer researchers focus on biomarkers that could provide diagnostics for the early detection of cancer.

The members of the initiative hope to improve early detection of cancer by making an impact in a variety of areas, including doing epidemiologic studies on risk factors, developing new and improved methods of diagnostic imaging, discovering and verifying new biomarkers as indicators of cancer, and developing new technologies to aid early detection.

These in turn depend on development of brain imaging tests or biomarkers that could be measured in the blood or other body fluids to allow a diagnosis of the disease in living people.

The report, which drew heavily on two Environmental Protection Agency (EPA) workshops held in 1995, also recommends more research on such topics as DNA biomarkers that can gauge an organism's exposure to endocrine disruptors; models for predicting how endocrine disruptors are metabolized; mechanisms of how endocrine disruptors act at a cellular level; and the effects of mixtures.

«This is a new idea — to create an excreted biomarker instead of relying on what the body gives you,» she says.

Precision cancer care focuses on identifying the specific biomarkers of a patient's cancer, which can help doctors make decisions about the best treatment options.

According to lead author Mr James Oliver of the Arthritis Research UK, Centre for Genetics and Genomics, Centre for Musculoskeletal Research, University of Manchester, UK, «in current clinical practice, RA drugs are administered on a trial and error basis; there are no clinical biomarkers of response to guide treatment decisions.

The technology, developed by MIT professor and Howard Hughes Medical Institute investigator Sangeeta Bhatia, relies on nanoparticles that interact with tumor proteins called proteases, each of which can trigger release of hundreds of biomarkers that are then easily detectable in a patient's urine.

«We extended this biomarker research to the domain of professional sports to test its merit as an objective and rapid way to determine players» severity of brain injury,» says lead author, Robert Siman, PhD, Research Professor of Neurosurgery at Penn. «This blood test may aid neurobiologically - informed decisions on suitability for return to play following a sports - related concussion.»

In an article titled, «Allergen Induced Pulmonary Inflammation Enhances Mammary Tumor Growth and Metastasis: Role of CH13L1,» featured on the cover of the current issue of the Journal of Leukocyte Biology, this new research suggests inflammation raises the level of a known biomarker of cancer, called «chitinase -3-like-1» or «CHI3L1,» in the inflamed tissue, which leads to increased metastasis and faster cancer growth in that tissue.

Effect of exercise on weight, body fat, and serum inflammatory biomarkers in breast cancer survivors with aromatase inhibitor arthralgias (joint pain): The hormones and physical exercise (HOPE) study.

«The findings of both studies support a growing body of research that suggests lifestyle interventions lower biomarkers associated with breast cancer recurrence and mortality, and improve quality of life,» said Melinda Irwin, PhD, co-program leader of the Cancer Prevention and Control Research Program at Yale Cancer Center, associate professor of Epidemiology at Yale School of Public Health, and principal investigator on both studies.

The HOPE study looked at the effect of exercise on body weight, body fat, and inflammatory biomarkers in 121 women with joint pain from taking aromatase inhibitors (AI) as adjuvant therapy.

They are investigating indoor emissions in other areas of Tibet and plan to link these measurements to a biomarker study based on blood samples of people living in the households.

To evaluate whether the experimental treatment is safe and whether it might be able to reduce frailty, Maharaj plans to run a battery of baseline testing on each clinical trial participant before they get their first infusion of young plasma and then monitor their changes for two years: That means cognitive exams, questionnaires about their quality of life and their indicators of frailty, and tests to measure biomarkers he believes are linked with aging, such as telomere lengths and DNA methylation.

In addition to presenting new treatment options for current and future tolerant patients who experience transplant rejection, shedding light on the mechanisms involved in tolerance recovery could lead to the discovery of biomarkers or bioassays that predict whether recipients can be safely taken off immunosuppression.

«Specifically, we are looking at the effects of these early factors on later levels of C - reactive protein (CRP), a biomarker associated with risk for cardiovascular and metabolic disease,» Metzger said.

Having discovered these important biomarkers of kidney function, the authors turned to kidney physiology experts on their team to explore the structural changes that occur in MMA disease.

When a smartphone is brought into proximity with the device, the wireless electronics trigger an app that captures a photo of the device and analyzes the image to yield data on the biomarker concentrations.

The device measures sweat and sweat biomarkers accurately and in real time, allowing athletes, military personnel, fitness pros and others to monitor sweat rate and electrolyte loss, so they can keep hydrated, replenish their electrolytes and stay on top of their game.

Designed for one - time use of a few hours, the device, placed directly on the skin of the forearm or back, even detects the presence of a biomarker for cystic fibrosis.

Lipkin is also a principal investigator, with Columbia psychiatrist Mady Hornig, on a $ 766,000 grant from NIH's infectious diseases institute to collect samples from hundreds of patients and controls, looking for biomarkers that could be used to diagnose the disease and searching for clues to its causes.

The team's next avenue of research will be focused on identifying a «biomarker» that can identify this distinct suppressive cell elsewhere in the body — for example, in blood or other samples — as a potential predictive clinical tool to determine when these cells are present in patients, which currently can not be done.

It also calls for «new funding for the National Institutes of Health (NIH) through a temporary «innovation fund,» which would give the agency an extra $ 8.75 billion over 5 years; $ 500 million per year would fund specific projects within NIH's 27 institutes, including research on biomarkers and precision medicine.

«Our work and that of our colleagues on stress and CRF have been mechanistically implicated in Alzheimer's disease, but agents that impact CRF signaling have not been carefully tested for therapeutic efficacy or long - term safety in animal models,» said the study's principal investigator and corresponding author Robert Rissman, PhD, assistant professor in the Department of Neurosciences and Biomarker Core Director for the Alzheimer's Disease Cooperative Study (ADCS).

The results of this study were published in the journal Cancer Epidemiology, Biomarkers, and Prevention on Sept. 21, 2016.