Sentences with phrase «on the cell division in»

«Our palladium - catalyzed sequential arylation reaction has been highly useful to rapidly synthesize a variety of triarylmethanes to be used for testing their effect on the cell division in plants,» says Nambo.

Not exact matches

In the clearest possible case, the ANT - OAR cell would differ from a zygote on all of the parameters noted above: The ANT - OAR cell would have a pattern of gene expression that is clearly distinct from a zygote; it would generate a homogeneous population of cells rather than multiple cell types; it would undergo simple cleavage divisions and not produce any multicellular structures.

Skop published her work in the 2 July 2004 issue of Science, and her image of Chinese hamster cells caught in the act of division landed on the cover.

One of the team's new biosensors is made from a nanoplasmonic material that is able to accommodate a large number of cells on a single substrate and to monitor cell proliferation, a fundamental process involving cell growth and division, in real time.

The film depicts several sperm attempting to fertilize the egg, «zooms in» on one sperm's tail to show how the dynein proteins move in sync to cause the tail to bend and flex, and ends with the sperm's successful journey into the egg and the initiation of cell division that will ultimately create a new organism.

The protein puts the immune system's brakes on, keeping its T cells from recognizing and attacking cancer cells, said Dr. Antoni Ribas, the study's principal investigator and a professor of medicine in the division of hematology - oncology at the David Geffen School of Medicine at UCLA.

After gaining a degree in molecular sciences from Wageningen University in 1991, he left the Netherlands to do his PhD on the structure of membrane protein at the Cell and Molecular Biosciences division of the University of Newcastle's medical school.

«As scientists, we have focused a good deal of attention on understanding the role of stem cells in the development of cancers, but there hasn't been a focus on mature cells,» said senior investigator Jason C. Mills, MD, PhD, a professor of medicine in the Division of Gastroenterology.

The researchers observed the effect of the synthetically produced molecule, JK - 31, on the growth and proliferation of a model human breast cancer cell line and found that it effectively blocked the protein cyclin - dependent kinase 1 (CDK1), which plays a key part in the process of the division of cancer cells, and therefore inhibited the proliferation of the cells.

(A correlation of 1 means that by knowing the variable on the x-axis — in this case, the lifetime number of stem cell divisions — one can predict the y - axis value 100 % of the time.)

The whole process is reminiscent of trial - and - error learning in which each cell explores — at its own rhythm and independently of cell division — different molecular possibilities (i.e. different genes turned on or off) before reaching a stable combination of active genes and the corresponding morphology.

We are trying to find out exactly how and why the nerve cells in the Alzheimer's brain decide to turn on their cell division system.

The egg's very structure, its scaffolding of proteins that guide the chromosomes during cell division, may also play a key role in turning on the necessary genes.

Franco Folli, M.D., Ph.D., professor of medicine in the Diabetes Division of the School of Medicine at The University of Texas Health Science Center at San Antonio, is co-author on the findings presented in Cell Stem Cell.

In a bid to progress beyond the shotgun approach to fighting cancer — blasting malignant cells with toxic chemicals or radiation, which kills surrounding healthy cells in the process — researchers at the Harvard - MIT Division of Health Sciences and Technology (HST) are using nanotechnology to develop seek - and - destroy models to zero in on and dismantle tumors without damaging nearby normal tissuIn a bid to progress beyond the shotgun approach to fighting cancer — blasting malignant cells with toxic chemicals or radiation, which kills surrounding healthy cells in the process — researchers at the Harvard - MIT Division of Health Sciences and Technology (HST) are using nanotechnology to develop seek - and - destroy models to zero in on and dismantle tumors without damaging nearby normal tissuin the process — researchers at the Harvard - MIT Division of Health Sciences and Technology (HST) are using nanotechnology to develop seek - and - destroy models to zero in on and dismantle tumors without damaging nearby normal tissuin on and dismantle tumors without damaging nearby normal tissue.

Each division is a scar, and each color on the pie chart shows in which cell type it occurs.

«We challenged a current dogma in the field that emphasized PLK1's role in mitosis (cell division) as a primary mechanism for cancer growth,» says Zheng Fu, Ph.D., lead investigator on the study, member of the Cancer Molecular Genetics research program at VCU Massey Cancer Center and assistant professor in the Department of Human and Molecular Genetics at the VCU School of Medicine.

They also found that this new compound does not have an effect on the cell division of animal cells, and that cell division restarts in plant cells upon removal of the compound.

Greider, a young new investigator at Cold Spring Harbor Laboratory (CSHL) on Long Island, New York, and her collaborator, molecular biologist Calvin Harley of McMaster University in Hamilton, Ontario, had shown 2 years earlier that telomeres shorten with each cell division.

Dr. Minako Ueda, Dr. Masakazu Nambo of the Institute of Transformative Bio-Molecules (ITbM) of Nagoya University and their colleagues have reported in the journal Plant and Cell Physiology, on the development of a series of triarylmethane compounds, which were tested on plant cells to see their effect on cell divisCell Physiology, on the development of a series of triarylmethane compounds, which were tested on plant cells to see their effect on cell diviscell division.

«We saw that chem7 had hardly any effect on the shapes of the cells and tissues, thus, suggesting that chem7 stops cell division in plant cells, but does not cause any severe damage to the shapes,» describes Ueda.

«As a result of screening about 200 compounds, we found that (3 - furyl) diphenylmethane (chem7), which is a triarylmethane that contains 2 phenyl groups and a furyl (a 5 - membered aromatic ring containing 4 carbons and an oxygen atom in the ring) group, had strong inhibitory activity on plant cell division,» says Ueda.

Firstly, salt stress causes a delay in cell division, leading to synchronization of cell cycles; secondly, survival probability depends on the individual bacterial cell's position in the cell cycle at the time of the second exposure.

In the final step in bacterial cell division, constriction of the so - called Z - ring, an annular structure that forms on the plasma membrane near the midpoint of the cell, gives rise to the two daughter cells: A research team led by Erwin Frey, who holds the Chair of Statistical and Biological Physics at LMU, has now used mathematical modelling to understand the mechanism that drives formation of the Z - ring, and in so doing have uncovered a novel class of pattern - forming mechanism in biological systemIn the final step in bacterial cell division, constriction of the so - called Z - ring, an annular structure that forms on the plasma membrane near the midpoint of the cell, gives rise to the two daughter cells: A research team led by Erwin Frey, who holds the Chair of Statistical and Biological Physics at LMU, has now used mathematical modelling to understand the mechanism that drives formation of the Z - ring, and in so doing have uncovered a novel class of pattern - forming mechanism in biological systemin bacterial cell division, constriction of the so - called Z - ring, an annular structure that forms on the plasma membrane near the midpoint of the cell, gives rise to the two daughter cells: A research team led by Erwin Frey, who holds the Chair of Statistical and Biological Physics at LMU, has now used mathematical modelling to understand the mechanism that drives formation of the Z - ring, and in so doing have uncovered a novel class of pattern - forming mechanism in biological systemin so doing have uncovered a novel class of pattern - forming mechanism in biological systemin biological systems.

The findings suggest that the information on the X and Y chromosomes that makes this division possible is primed during gametogenesis — the process of creating ovum or sperm cells — in the parents.

Aurora kinase has many subtypes, but is generally known for its role in cell division — an additional link between regeneration and division that helped to confirm Lin was on to something.

The IBMC researchers (Porto University, Portugal) reveal that the existence of specific signals on microtubules — which work as intracellular highways — give directions to chromosomes of which route to take in the course of cell division.

The more it's expressed only on cancer cells, the more targeted the therapy becomes,» says Colin Weekes, MD, PhD, CU Cancer Center investigator and assistant professor in the Division of Oncology at the CU School of Medicine.

The researchers found that timing — specifically, the phase of the cell division cycle that bacteria were in when exposed to the antibiotic — had a significant effect on susceptibility.

Partly based on his MIT Ph.D. thesis research performed in yeast, Sheltzer suspects aneuploidy causes errors in DNA replication, as well as problems with chromosome segregation during cell division.

But most of our 23,000 genes are involved in fundamental processes such as cell division, and do not have any known effects on our character.

The complexity of the 3 - D multicellular environment can be overwhelming, Betzig says, but the clarity of his team's imaging permits them to computationally «explode» apart the individual cells in tissue to focus on the dynamics within any particular one, such as the remodeling of internal organelles during cell division.

By means of their mouse model, the hormone researchers from Ulm could prove that dexamethasone — mediated through the dimer function of GR — leads to the release of sphingosine -1-phosphate in the macrophages, a tissue hormone that fosters growth, migration and division of cells and has a stabilization effect on inner vessel walls.

This results in an unequal (asymmetric) cell division, generating a relatively small cell on top and a large cell at the bottom.

He is now a postdoctoral scholar in the Division of Biology and Biological Engineering at Caltech, working with Lior Pachter on statistics for omics based cell biology.

For example, a gene called p53, which normally acts as a brake on cell division, turns out to be mutated or lost in about half of all tumours.

In the new study, Sunney Xie of Peking University and Harvard University teamed up with Qiao and Fuchou Tang of Peking University to develop a method for sequencing the entire genomes of polar bodies — cells that arise as a byproduct of egg cell division and often die later on.

In order to investigate their specific roles, they used inhibitors of each protein to see their effect on zygote polarization and asymmetric cell division.

The activity of tyrosine kinases is typically regulated in an auto - inhibitory fashion, but the BCR - Abl fusion gene codes for a protein that is «always on» or continuously activated leading to unregulated cell division (i.e. cancer).

Thus, neural derivatives of disease - specific human pluripotent stem cells constitute a relevant biological resource for exploring the impact of adult - onset HD mutations of the HTT gene on the division of neural progenitors, with potential applications in HD drug discovery targeting HTT - dynein - p150Glued complex interactions.

Simon's strategy is to compare the effects of a drug on a normal strain of yeast and a strain with a mutation in one of the many genes that affect normal cell division - a property that is disrupted in cancerous cells.

While retroviruses generally only infect dividing cells (because their access to the host genome is thought to rely on the breakdown of the nuclear envelope that occurs in mitosis [Roe et al., 1993]-RRB-, lentiviruses are a genus of the retroviral family that can infect non-dividing cells (possibly through the use of nuclear localization signals by the viral components [Bukrinsky et al., 1992]-RRB-, and thus, offer an advantage when transducing certain cell types that exhibit limited cell division (e.g., neurons).

The key point is that this work demonstrates that MSC exert veto effects on T cells and it is significant in demonstrating that the mechanisms inducing MSC tolerance are not confined to patterns of cytokine secretion but extend to direct modulation of T cell division.

She also investigates how asymmetric cell division impacts on the cellular potential to give rise to multiple lineages in vivo.

«This research, and the results it has produced, illustrate the great value of this time series reflected in the cell samples,» said Lisa Ballance, director of the Science Center's Marine Mammal and Turtle Division, and coauthor on this paper.

Thus the search is on is to discover additional cancer - causing genes «downstream» of TET mutations that drive uncontrolled cell division in either context.

The Kops group studies the processes involved in chromosome segregation during cell division, with a focus on molecular mechanisms, evolution and chromosomal instability.

Defeated by an initial project on in vitro fertilization in mice, he had switched to studying how yeast cells duplicate their genome during cell division.

In their Nature paper, Singh's team also showed for the first time that this transcriptional repression was dependent on breakdown and reformation of the nuclear membrane during cell division.

The outcome of a given division is unpredictable, but in homeostasis the probabilities of producing two progenitor and two differentiating daughters are the same, so that on average, equal numbers of progenitors and differentiating cells are produced across whole population of progenitors.