Sentences with phrase «on the cell division of»

They also found that this new compound does not have an effect on the cell division of animal cells, and that cell division restarts in plant cells upon removal of the compound.

Not exact matches

In the clearest possible case, the ANT - OAR cell would differ from a zygote on all of the parameters noted above: The ANT - OAR cell would have a pattern of gene expression that is clearly distinct from a zygote; it would generate a homogeneous population of cells rather than multiple cell types; it would undergo simple cleavage divisions and not produce any multicellular structures.

Skop published her work in the 2 July 2004 issue of Science, and her image of Chinese hamster cells caught in the act of division landed on the cover.

Y. Ning et al., Genetic analysis of indefinite division of human cells: Evidence for a cell senescence - related gene (s) on human chromosome 4.

One of the team's new biosensors is made from a nanoplasmonic material that is able to accommodate a large number of cells on a single substrate and to monitor cell proliferation, a fundamental process involving cell growth and division, in real time.

By measuring how the light has changed once it emerges through the other side of the slide, the researchers can detect and monitor processes occurring on the sensor surface, such as cell division.

The film depicts several sperm attempting to fertilize the egg, «zooms in» on one sperm's tail to show how the dynein proteins move in sync to cause the tail to bend and flex, and ends with the sperm's successful journey into the egg and the initiation of cell division that will ultimately create a new organism.

After demonstrating the existence of several genes that control indefinite cell division, she, a grad student named Yi Ning, and their colleagues found a candidate for one of those genes on chromosome 4.

The protein puts the immune system's brakes on, keeping its T cells from recognizing and attacking cancer cells, said Dr. Antoni Ribas, the study's principal investigator and a professor of medicine in the division of hematology - oncology at the David Geffen School of Medicine at UCLA.

After gaining a degree in molecular sciences from Wageningen University in 1991, he left the Netherlands to do his PhD on the structure of membrane protein at the Cell and Molecular Biosciences division of the University of Newcastle's medical school.

«As scientists, we have focused a good deal of attention on understanding the role of stem cells in the development of cancers, but there hasn't been a focus on mature cells,» said senior investigator Jason C. Mills, MD, PhD, a professor of medicine in the Division of Gastroenterology.

The researchers observed the effect of the synthetically produced molecule, JK - 31, on the growth and proliferation of a model human breast cancer cell line and found that it effectively blocked the protein cyclin - dependent kinase 1 (CDK1), which plays a key part in the process of the division of cancer cells, and therefore inhibited the proliferation of the cells.

(A correlation of 1 means that by knowing the variable on the x-axis — in this case, the lifetime number of stem cell divisions — one can predict the y - axis value 100 % of the time.)

«There has been ongoing debate about whether the methylation mark can be passed on through cell divisions and across generations, and we've now shown that it is,» said corresponding author Susan Strome, a professor of molecular, cell and developmental biology at UC Santa Cruz.

The whole process is reminiscent of trial - and - error learning in which each cell explores — at its own rhythm and independently of cell division — different molecular possibilities (i.e. different genes turned on or off) before reaching a stable combination of active genes and the corresponding morphology.

The enzyme lengthens the caps, or telomeres, on the ends of chromosomes, which wear off during each cell division.

The egg's very structure, its scaffolding of proteins that guide the chromosomes during cell division, may also play a key role in turning on the necessary genes.

Biochemist Peter Davies suspects the vast majority of research is on the wrong track: The disease is caused by improper cell division, not plaques or tangles.

Franco Folli, M.D., Ph.D., professor of medicine in the Diabetes Division of the School of Medicine at The University of Texas Health Science Center at San Antonio, is co-author on the findings presented in Cell Stem Cell.

The researchers chose to focus on the cell - division machinery, studying the meiotic spindle, the structure composed of microtubules that attaches to chromosomes, pulling them to opposite sides of a cell before it divides.

In a bid to progress beyond the shotgun approach to fighting cancer — blasting malignant cells with toxic chemicals or radiation, which kills surrounding healthy cells in the process — researchers at the Harvard - MIT Division of Health Sciences and Technology (HST) are using nanotechnology to develop seek - and - destroy models to zero in on and dismantle tumors without damaging nearby normal tissue.

6mA was also found consistently on both strands of DNA, which may enable propagation of methylation through cell division.

Arrested cell division may also be a problem for lab - made hybrids of two subspecies of Drosophila pseudoobscura on their way to becoming separate species.

During that time, 42 of these stem cells underwent a spurt of division, churning out two kinds of cells: intermediate cells that would go on to produce nerve cells as well as mature nerve cells themselves.

This provides a wealth of information on the patterns of cell shape, motion and division.

«We challenged a current dogma in the field that emphasized PLK1's role in mitosis (cell division) as a primary mechanism for cancer growth,» says Zheng Fu, Ph.D., lead investigator on the study, member of the Cancer Molecular Genetics research program at VCU Massey Cancer Center and assistant professor in the Department of Human and Molecular Genetics at the VCU School of Medicine.

«With the help of animal biologists, we found that chem7 had no effect on budding yeasts and human cells, which indicates that chem7 does not inhibit the cell division of animal cells.»

«Our palladium - catalyzed sequential arylation reaction has been highly useful to rapidly synthesize a variety of triarylmethanes to be used for testing their effect on the cell division in plants,» says Nambo.

Greider, a young new investigator at Cold Spring Harbor Laboratory (CSHL) on Long Island, New York, and her collaborator, molecular biologist Calvin Harley of McMaster University in Hamilton, Ontario, had shown 2 years earlier that telomeres shorten with each cell division.

Dr. Minako Ueda, Dr. Masakazu Nambo of the Institute of Transformative Bio-Molecules (ITbM) of Nagoya University and their colleagues have reported in the journal Plant and Cell Physiology, on the development of a series of triarylmethane compounds, which were tested on plant cells to see their effect on cell divisCell Physiology, on the development of a series of triarylmethane compounds, which were tested on plant cells to see their effect on cell diviscell division.

«We saw that chem7 had hardly any effect on the shapes of the cells and tissues, thus, suggesting that chem7 stops cell division in plant cells, but does not cause any severe damage to the shapes,» describes Ueda.

«As a result of screening about 200 compounds, we found that (3 - furyl) diphenylmethane (chem7), which is a triarylmethane that contains 2 phenyl groups and a furyl (a 5 - membered aromatic ring containing 4 carbons and an oxygen atom in the ring) group, had strong inhibitory activity on plant cell division,» says Ueda.

Firstly, salt stress causes a delay in cell division, leading to synchronization of cell cycles; secondly, survival probability depends on the individual bacterial cell's position in the cell cycle at the time of the second exposure.

In the final step in bacterial cell division, constriction of the so - called Z - ring, an annular structure that forms on the plasma membrane near the midpoint of the cell, gives rise to the two daughter cells: A research team led by Erwin Frey, who holds the Chair of Statistical and Biological Physics at LMU, has now used mathematical modelling to understand the mechanism that drives formation of the Z - ring, and in so doing have uncovered a novel class of pattern - forming mechanism in biological systems.

The approach developed by the MGH team focuses on small areas of the human genome — so - called polyguanine (poly - G) repeats that are particularly susceptible to mutation, with genetic «mistakes» occurring frequently during cell division.

This asymmetric cell division leads to small and large cells on the top and bottom part of the embryo, respectively.

The findings suggest that the information on the X and Y chromosomes that makes this division possible is primed during gametogenesis — the process of creating ovum or sperm cells — in the parents.

This division has to be «asymmetric,» meaning that only one of the two cells generated during the stem cell division goes on to differentiate, while the other cell remains a stem cell.

Now known as a blastocyst, the embryo undergoes a dramatic division of cell fate, forming a distinct outer layer of cells and an equally distinct bulge of about 20 or 30 cells on the inside.

The research group working at IBMC focused on the exact moment of cell division, when cells assemble a new microtubule network, which is then arranged as a very well - known structure: the mitotic spindle.

The IBMC researchers (Porto University, Portugal) reveal that the existence of specific signals on microtubules — which work as intracellular highways — give directions to chromosomes of which route to take in the course of cell division.

The more it's expressed only on cancer cells, the more targeted the therapy becomes,» says Colin Weekes, MD, PhD, CU Cancer Center investigator and assistant professor in the Division of Oncology at the CU School of Medicine.

The researchers found that timing — specifically, the phase of the cell division cycle that bacteria were in when exposed to the antibiotic — had a significant effect on susceptibility.

But most of our 23,000 genes are involved in fundamental processes such as cell division, and do not have any known effects on our character.

The complexity of the 3 - D multicellular environment can be overwhelming, Betzig says, but the clarity of his team's imaging permits them to computationally «explode» apart the individual cells in tissue to focus on the dynamics within any particular one, such as the remodeling of internal organelles during cell division.

By means of their mouse model, the hormone researchers from Ulm could prove that dexamethasone — mediated through the dimer function of GR — leads to the release of sphingosine -1-phosphate in the macrophages, a tissue hormone that fosters growth, migration and division of cells and has a stabilization effect on inner vessel walls.

They are driven by stem cells with the proneural pattern of gene expression and depend on rapid cell division and angiogenesis — creation of new blood vessels.

He is now a postdoctoral scholar in the Division of Biology and Biological Engineering at Caltech, working with Lior Pachter on statistics for omics based cell biology.

For example, a gene called p53, which normally acts as a brake on cell division, turns out to be mutated or lost in about half of all tumours.

The demands of rapid cell division put a strain on cancer cells, and the approach works by tipping cell stress over the edge.