Sentences with phrase «on therapeutic targets»
Ongoing epidemiological and genomic surveillance is imperative to identify viral determinants of transmission dynamics, monitor viral changes and adaptation, ensure accurate diagnosis, guide research on therapeutic targets, and refine public health strategies.
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It seems to me that knowing how the drug works, how it acts on a therapeutic target, is an important consideration in prioritizing potential treatments.
Not exact matches
Pharmaceutical and biotech companies are looking to pare portfolios and focus on growing targeted therapeutic areas, says Vikram Kapur of Bain & Company.
Richard Hargreaves, executive director of imaging at Merck Research Laboratories, says, «Nuclear imaging using radiotracers gives the opportunity to put your arms around proof - of - concept very early in a drug discovery and development program by focusing the selection of doses to study on those proven to deliver enough drug to the target therapeutic sites.»
This study provides evidence of a direct effect of AMPK on nicotine withdrawal symptoms and suggests that activating AMPK in the brain could be a therapeutic target for smoking cessation.
The pathologist of the Department of Pathology at the University Hospital of Bellvitge August Vidal explained that «this tumorigenic transformation depends on Dicer protein that could serve as a marker for the presence of tumor cells, or as a therapeutic target.»
EMD Serono, Kirschbaum says, «focuses on the development of targeted cancer therapies on three therapeutic platforms: targeting the tumor cell, the tumor environment, and the immune system.»
This new technology offers two main advantages based on the use of molecular tools to manipulate the genome: firstly, working models that had not existed up until now for the study of tumour biology and, secondly, their application will eventually allow for the study of new therapeutic targets and therapies.
I am sure that, on the basis of known structures, eBDIMS will be able to generate new hypotheses and will pave the way to a new generation of therapeutic targets.»
The work, which appeared in Cell Reports on January 2, 2018, suggests that astrocytes may be good therapeutic targets to prevent or reverse the effects of normal aging.
Therapeutic hypothermia (targeted temperature management) is an established intervention for certain types of cardiac arrest, stroke and asphyxia patients and is used to protect neurological function, but its impact on renal protection in the transplantation setting has been unknown, according to the researchers.
Based on a report published on August 20, 2015 in Nature Communications, it has been established that certain nutrients support CML stem cell activity in vivo, thus pointing towards a potential therapeutic target for CML therapy.
«We gave ourselves six to nine months and put a half - dozen people on it to see if there were therapeutic targets lurking in there,» recalled Galas.
«Our findings suggest that PRMT5 is a possible prognostic factor and therapeutic target for glioblastoma, and they provide a rationale for developing agents that target PRMT5 in this deadly disease,» says co-corresponding author Robert A. Baiocchi, MD, PhD, associate professor of medicine and a hematologist at the OSUCCC — James who is also collaborating on an Ohio State effort to develop a PMRT5 inhibitor.
Koo and colleagues are now working on novel therapeutic approaches for targeted interventions, which can be potentially developed for clinical use.
«Clinicians lack specific guidance to target their therapeutic interventions to maximize impact on outcome.
«The findings help us to shed light on developing new therapeutic strategies by targeting or pharmacologically upregulating MyD88 short production,» Li said.
The authors, who are now planning to begin clinical trials based on this study, state that the three enzymes can be promising therapeutic targets for a diverse and broad group of DLBCL patients.
«Although this is basic scientific research using animal models, these studies are shedding light on the molecular mechanisms that control male fertility, and are helping us to better understand the causes of many cases of infertility and enabling new horizons to be opened up in the development of therapeutic targets and strategies to combat it,» explained Dr Subirán.
«By being able to distinguish benign from malignant aging based on distinctive RNA splicing patterns, we can develop therapeutic strategies that selectively target leukemia stem cells while sparing normal hematopoietic stem cells,» she said.
It is still too early to think about its clinical application, but the work reveals a new genetic target on which to look for new possible therapeutic strategies.
Research fields are diverse, including basic research on cell proliferation, analysis of tumour cells and tissues to detect gene mutations, and identification of potential therapeutic targets in cancer.
Hajishengallis, Chavakis and their colleagues identified the protein on hematopoetic stem cells with which Del - 1 interacts, the ß3 integrin, perhaps pointing to a target for therapeutic interventions down the line.
«Future studies on how PAF / PAFR signaling controls UCP1 levels through beta3 - AR production in the BAT of animals and humans may reveal new therapeutic targets to treat metabolic disorders associated with obesity,» said Junko Sugatani, Ph.D., a researcher involved in the work from the Department of Pharmaco - Biochemistry at the School of Pharmaceutical Sciences at the University of Shizuoka in Shizuoka, Japan.
The second branch of the combination therapy, the low - dose metronomic chemotherapy, was similarly found to exert its therapeutic effect through a novel, hitherto unrecognized mechanism: The metronomic chemotherapy turned out to not primarily target the tumor cells, but to act on the recruitment of yet another tumor - promoting cell population from the bone marrow.
A $ 1.7 million drug discovery effort to identify molecular and genetic risk factors and new therapeutic targets for cognitive decline and Alzheimer's disease, based on data from the Religious Order Study and the Rush Memory and Aging Project.
«The LINK - A dependent HIF1 signalizing cascade and the consequent effects on cancer cells implicate LINK - A and LINK - A interacting kinases and receptors as promising therapeutic targets for TNBC.»
He envisions a global initiative worth about $ 200 million a year — half from private money and half from public and charitable sources — that would focus solely on new therapeutic targets.
New studies from the Abramson Cancer Center of the University of Pennsylvania are providing fresh clues on potentially effective combinations with CAR T therapy in brain cancer as well as a novel therapeutic target in head and neck cancer, and also providing greater understanding of the mechanisms of resistance in pancreatic cancer.
In preliminary findings presented at the 2016 San Antonio Breast Cancer Symposium, researchers showed that older patients were as likely as younger patients to receive targeted therapy and enroll in therapeutic trials based on their sequencing results.
An international study led by researchers at Monash University» Biomedicine Discovery Institute (BDI) has shone light on the way the Hepatitis C Virus (HCV) hijacks the communication systems in the host cells it infects, uncovering potential new therapeutic targets for the disease.
Research teams are also developing ways to innovate the early drug - discovery process, including pioneering methods to rapidly identify drug targets and test them on laboratory models and finding and testing new therapeutic possibilities for already FDA - approved drugs.
Future investigations on the postsynaptic role of p - tau will be necessary to understand its toxic effects and provide insights into new therapeutic targets for maintaining spine integrity, highlighting the importance of tau toxicity as well as the impact of sex on tau - pathology.
The focus is translational science and patient related research focusing on disease understanding, target validation and finding / validating new therapeutic opportunities.
Taken together, these observation impinge on one central problem: the development of rational targeting strategies aimed at overcoming therapeutic resistance require the precise elucidation of the molecular mechanisms whereby carcinoma cells that undergo EMT acquire the functional traits that render them resistant to conventional therapy.
Our aim is to highlight the genetic networks that can impact on DM1 biomarkers to provide new therapeutic targets for treatments by chemical compounds.
On the Bio front, we are starting to see NMR techniques applied for the analysis of new and interesting therapeutic targets.
iTeos and Adimab LLC are collaborating on the discovery, development and commercialization of multiple, antibody - based therapeutic programs, with Adimab using its antibody discovery and optimization platform to identify fully human therapeutic antibodies against targets selected by iTeos.
AMP T2D focuses on type 2 diabetes genetics, seeking to use and supplement the substantial amount of human genetic data available from people with type 2 diabetes, or at risk of developing it, to identify and validate novel molecules and pathways as targets for therapeutic development.
My Honours project focused on genetically validating the Signal Transducer and Activator of Transcription 3 (STAT3) protein as a therapeutic target by using a novel transgenetic mouse model in which a short hairpin RNA directed against STAT3 can reversibly be induced by the administration of doxycycline.
Our collaborations with industry, government agencies, and academia focus on developing new disease models, elucidating new therapeutic targets to develop treatments, safety testing on new chemical entities, enabling better and safer design of new consumer products, and new applications in personalized healthcare.
Early - phase data on larotrectinib validate TRK fusions as therapeutic targets and show they lead to tumor - agnostic sensitivity to this agent.
Clinical studies conducted by Steinman have shed light on the therapeutic potential of DCs, particularly as targets for cancer vaccination.
Ipsen will provide funding for targeted research programs carried out at the Salk Institute by researchers on novel therapeutic concepts for the treatment of pituitary adenomas, cancer and neurodegenerative diseases.
Currently, Schreiber and colleagues in the Broad's Center for the Science of Therapeutics focus on integrating human biology with chemistry and chemical biology to discovery small molecules that modulate therapeutic targets at the heart of disease.
By comparing all of the genes that are active in disease and normal tissue, one can get valuable information on new pathways and potential therapeutic targets.
He focused on the Src kinase, an important therapeutic target for cancer.
Our group has 3 major goals: Develop novel therapeutic approaches based on centrosomal clustering To further develop our first prototype inhibitors of centrosomal clustering preclinically and to establish a robust and specific high throughput small molecule screen Discover key events in myeloma pathogenesis To investigate the pivotal transition from the pre-malignant, asymptomatic to malignant, symptomatic stages of plasma cell dyscrasias in order to understand the pathophysiology and thereby identify novel targets Translate small molecule therapeutics from bench to clinical trials To evaluate novel agents in the preclinical setting and to initiate early phase clinical trials in hematologic malignancies with focus on multiple myeloma
To do that, large compounds libraries are tested on a biological model showing a specific therapeutic target.
«Our research on the role of blood proteins in brain functions has identified new targets for therapeutic intervention in multiple sclerosis and other neurological diseases,» said Dr. Akassoglou.