Sentences with phrase «on tissue analysis»

When Abrikosov's autopsy failed to quell rumors — only 8 of 27 physicians who treated Lenin agreed to sign it — a second report was issued based on tissue analysis.

Not exact matches

Biopsy to remove tissue for diagnostic analysis can damage lactation ducts or nerves depending on the technique, amount of tissue removed and location of the incision.

Indeed, the team identified high variation in adjacent «normal» tissue samples, which are typically used as control samples for comparison in analyses based on mean gene expression.

Research fields are diverse, including basic research on cell proliferation, analysis of tumour cells and tissues to detect gene mutations, and identification of potential therapeutic targets in cancer.

The tissue analyses yielded another surprise: «Our histological 3D reconstruction shows that the skin covering the tubercles on the skull is very thin and consists only of a transparent layer of epidermis, «explains Dr. Martin Heß from the BioCenter of Ludwig - Maximilians - Universität (LMU) in Munich.

The newly developed method, which researchers are calling TumorTracer, are based on analyses of DNA mutations in cancer tissue samples from patients with metastasized cancer, i.e. cancer which has spread.

«Computer accurately identifies and delineates breast cancers on digital tissue slides: Deep - learning network possible step toward automating biopsy slide analysis.»

To begin filling in these many gaps, the scientists are calling on researchers to assess and report the health of individual marine mammals through observation, photography, tissue samples, analysis of waxy ear plugs, and tags that record data as the animals dive.

Their analysis is designed to help surgeons minimize the tissue removed while operating on cancer patients by providing highly accurate, real - time information about the health of the excised tissue.

Using this «Ribotag» approach tissue - specific changes under DR have been measured in muscle, fat, gut, heart, neurons, germline and malpighian tubules, showing a highly tissue specific response upon DR.. We are developing mechanistic models of gene expression regulation and conducting comprehensive bioinformatics analyses on UTRs, promoters and the coding sequences of various elements of differentially regulated genes.

This analysis compares the relative change of all probe sets on the array and unbiasedly groups the four tissue samples based on their similarity [9].

Proteomics (Fagerberg et al, «Analysis of the human tissue - specific expression by genome - wide integration of transcriptomics and antibody - based proteomics») with a focus in the article on the tissue - specific pattern in the human body.

Analyses were performed in triplicate on tissue from embryos on three different days from three different females.

It concentrates on analysis of gene function at all levels: the gene and its product, the cell and cellular interactions, embryonic tissues and the entire animal.

This is in contrast to conventional biochemistry and molecular biology, which focuses on analyses of whole tissue samples and whole microbial populations or communities.

The CellDevo Track focuses on the study of molecular mechanisms in eukaryotic cells and their role in tissue formation, with the level of analysis ranging from single molecules to single cells, from cells to tissues, and from tissues to whole organisms.

We use a technique that is based on the incorporation of nuclear bomb test derived 14C into genomic DNA, which allows for the analysis of cell and tissue turnover in humans.

We see that Adipose — Subcutaneous, Lung, Thyroid and Skin — Sun Exposed (Lower leg) are the tissues that consistently appeared on more optimal subsets of all sizes; and these tissues are also the ones that appear among the top most stable ones on the previously mentioned stability analysis.

We focus on squamous tissues, the skin epidermis and the lining of the oesophagus, using transgenic models, novel sequencing approaches, live imaging and single cell analysis to uncover key steps in cancer development, with aim of developing rational interventions to decrease cancer risk.

Functional analysis of genes with recurrent exons (i.e., with association with PMI in more than two tissues) shows a noteworthy enrichment on RNA binding and RNA splicing genes (Supplementary Fig. 18b, c).

Most evidence for feeding on the host body was accumulated for Caribbean Typton species (T. carneus and T. distinctus); however, stomach analyses confirmed that many other taxa also feed on their host tissues (Table 1).

In this document, openly available for download, we provide an overview of the effort; our framework for the first draft of the atlas; descriptions of the technology and data analysis tools available to build the atlas; an introduction to the Data Coordination Platform that will host the data for researchers worldwide; a deeper look at biological systems we plan to explore and map; and details on the organization and governance of the HCA consortium and its relationships to the public (including ethical considerations regarding organ and tissue donors) and to funding support.

Histopathological analysis was performed on the placenta and brain tissue from infants who died.

A White Paper, openly available for download, provides an overview of the effort; our framework for the first draft of the atlas; descriptions of the technology and data analysis tools available to build the atlas; an introduction to the Data Coordination Platform that will host the data for researchers worldwide; a deeper look at biological systems we plan to explore and map; and details on the organization and governance of the HCA consortium and its relationships to the public (including ethical considerations regarding organ and tissue donors) and to funding support.

Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters

Remaining prostate tissue was formalin - fixed and paraffin - embedded (FFPE), sectioned with a microtome and placed on microscope slides for FISH analysis (referred to as FFPE sections).

Although many common genes were expressed in the three tissues, cluster analysis based on transcript levels revealed distinct gene expression profiles of the d - 18 EET (Fig. 2C and SI Appendix, Fig.

Our bioinformatics analysis, based on multiple independent large - size cohorts shows that MELK is strongly overexpessed in BBC / TNBC, not only compared to normal breast tissues, but also compared to luminal or ER / PR + breast cancer.

Tissues were analyzed... the endpoints include (g / 100g) moisture, fat, protein, ash, carbohydrates... Protocol was based on established methodology by the Association of Official Analytical Chemist's (AOAC) Official Methods of Analysis (AOAC, 2000) and is briefly described herein.

I then began coaching clients on Hair Tissue Mineral Analysis (HTMA) tests.

If you're doing an ARL or TEI program based on your HTMA (hair tissue mineral analysis), you simply need to let the program heal your adrenal glands so they produce sufficient amounts of all the hormones, including progesterone, estrogen, testosterone and a few others.

Thus, one will have higher blood sugar when they have high amounts of calcium in their tissues that is reflected on a hair mineral analysis.

Definitive diagnosis is based on laboratory analysis of affected tissues by fluorescent antibody techniques.

The daily job routine you will follow are: performing initial diagnosis, collecting and measuring internal organs, conducting laboratory experiments, and picking up tissues you believe can reveal something on further analysis.

Lab Assistant — Parker Children's Hospital — March 2007 — May 2012 • Prepared specimens for analysis and distribution following laboratory procedures; performed laboratory functions and worked with quality and regulations indicators • Obtained blood from patients using fingerstick, heelstick, or venipuncture in order to procure blood samples for analysis; ensured correct patient identification through registration system and made sure that correct tests were ordered • Responded to patient needs, including attention to phone calls, courier deliveries, and removal of pneumatic tubes; referred unresolved issues to supervisory on duty • Filed and pulled pathology slides and performed proper tissue disposal when necessary; assisted supervising medical technologist with post-mortem specimens • Performed inventory and general maintenance of lab area; reported equipment repair needs and supplies required for efficient running of the lab

Conducted Pesticide / PCB and Semivolatile analyses of environmental and tissue matrices on GC and GC / MSD systems.

Lockheed Martin Co., Inc., City • ST 1999 — 2009 Environmental Analyst Conducted NELAC Certified Semivolatile and Volatile analyses of environmental and tissue matrices on GC / MSD systems for US EPA Emergency Response Team using US EPA and NIST Methodology.

Professional Duties & Responsibilities Biomedical and biotechnology engineer with background in design of biomaterials, biosensors, drug delivery devices, microfrabrication, and tissue engineering Working knowledge of direct cell writing and rapid prototyping Experience fabricating nanocomposite hydrogel scaffolds Proficient in material analysis, mechanical, biochemical, and morphological testing of synthetic and biological materials Extensive experience in bio-imaging processes and procedures Specialized in mammalian, microbial, and viral cell culture Working knowledge of lab techniques and instruments including electrophoresis, chromatography, microscopy, spectroscopy, PCR, Flow cytometery, protein assay, DNA isolation techniques, polymer synthesis and characterization, and synthetic fiber production Developed strong knowledge of FDA, GLP, GMP, GCP, and GDP regulatory requirements Created biocompatible photocurable hydrogels for cell immobilization Formulated cell friendly prepolymer formulation Performed surface modification of nano - particle fillers to enhance their biocompatibility Evaluated cell and biomaterial interaction, cell growth, and proliferation Designed bench - top experiments and protocols to simulate in vivo situations Designed hydrogel based microfluidic prototypes for cell entrapment and cell culture utilizing computer - aided robotic dispenser Determined various mechanical, morphological, and transport properties of photocured hydrogels using Instron, FTIR, EDX, X-ray diffraction, DSC, TGA, and DMA Assessed biocompatibility of hydrogels and physiology of entrapped cells Evaluated intracellular and extracellular reactions of entrapped cells on spatial and temporal scales using optical, confocal, fluorescence, atomic force, and scanning electron microscopies Designed various biochemical assays Developed thermosensitive PET membranes for transdermal drug delivery application using Gamma radiation induced graft co-polymerization of N - isopropyl acylamide and Acrylic acid Characterized grafted co-polymer using various polymer characterization techniques Manipulated lower critical solution temperature of grafted thermosensitive co-polymer Loaded antibiotic on grafted co-polymer and determined drug release profile with temperature Determined biomechanical and biochemical properties of biological gels isolated from marine organisms Analyzed morphological and mechanical properties of metal coated yarns using SEM and Instron Performed analytical work on pharmaceutical formulations using gas and high performance liquid chromatography Performed market research and analysis for medical textile company Developed and implement comprehensive marketing and sales campaign