Sentences with phrase «on translational studies»
Also, genes that code for receptor tyrosine kinases, a family of receptors on the surface of cells, may rearrange to form multiple distinct gene fusion partners, as evidenced in an article by Kulkarni, et al, on a translational study involving a patient who developed a BRAF fusion following treatment with a BRAF inhibitor1.
http://www.cinj.org/ Not exact matches
«But that's really not what the study tested,» says Manji, whose commentary on the study was published in the same issue of Science Translational Medicine.
«To treat most forms of hearing loss, we need to find a delivery mechanism that works for all types of hair cells,» said neurobiologist David Corey, co-senior investigator on the study and the Bertarelli Professor of Translational Medical Science at HMS.
An example of such translational engagement is the NOAA - funded Climate Impacts Group at the University of Washington, Seattle, which studies the impacts of climate change on water, fishery, coastal, and forest resources in the Pacific Northwest.
«The study focuses our attention on a particular part of the immune system that already exhibits changes caused by Alzheimer risk factors in people in their 20s and 30s,» said Philip L. De Jager, MD, PhD, director, BWH Program in Translational NeuroPsychiatric Genomics, associate member at the Broad Institute, senior study author.
The research, led by Knut Wittkowski, biostatistician in the Center for Clinical and Translational Science at The Rockefeller University Hospital, is a twist on a traditional data - mining technique known as a genome - wide association study.
The journal's home page explains that translational medicine «builds on basic research advances — studies of biological processes using cell cultures, for example, or animal models — and uses them to develop new therapies or medical procedures.»
«We are excited that our translational research team of clinicians and basic researchers have come together to present these novel findings and hope that future studies and trials based on this work can move forward to bring targeted therapies for TED,» commented Dr. Phipps.
With the technology on track for commercialization, Rogers» team, including Dr. Roozbeh Ghaffari, the director of translational science at CBIE, is continuing to test the microfluidic devices in scaled studies with an expanding collection of partners.
The method, published in the 1 March issue of Science Translational Medicine, could help make organ banks a viable option for transplant surgeons, said John Bischof of the University of Minnesota, the senior author on the study.
«You shouldn't be testing everybody, but if there are reasons to believe that a test for H. pylori may come back positive, and it does come back positive, you should go on to treat,» says Dr. Traci Murakami, previous gastroenterology fellow at the UA and graduate of the clinical and translational research graduate certificate at the Mel and Enid Zuckerman School of Public Health, now an assistant clinical professor of medicine at the University of Hawaii, Manoa, and lead author of the study.
«It is hoped that future studies distinguishing differences in responsiveness between sexes, age groups or disease conditions could lead to better tailored exercise prescription for health benefits,» said Benjamin F. Miller, Ph.D., study author from the Translational Research on Aging and Chronic Disease Laboratory at Colorado State University in Fort Collins, CO..
The study's findings, published in the January 10, 2018 issue of Science Translational Medicine, and featured on the cover, could help doctors better understand Crohn's disease, determine specifically who's at risk, and develop new drugs for treatment and / or prevention by targeting this specific gene.
The trial has also contributed 1000 blood samples to the UK translational research study RAPPER (Radiogenomics: Assessment of Polymorphisms for Predicting the Effects of Radiotherapy), which aims to ultimately develop individualised radiotherapy plans based on the analysis of individual patients» genetics.
The study was published on February 22nd in the journal Translational Psychiatry (Nature Publishing Group).
A new study, published online May 26 in Science Translational Medicine, presents a thorough profile of exercise's impact on the human body's metabolites in plasma — and reveals vast biological differences among more - and less - fit individuals.
«We hope our findings reassure women with epilepsy and clinicians who are counseling these women on family planning,» says Jacqueline French, MD, professor of Neurology and Director of Translational Research and Clinical Trials at NYU Langone's Comprehensive Epilepsy Center, and the study's first author and co-principal investigator.
In this review topic, researchers looked at novel translational noise studies demonstrating the molecular mechanisms that may lead to impaired vascular function, recent epidemiologic evidence of noise - induced cardiovascular disease, and the non-auditory effects of noise and their impact on the cardiovascular system.
However the bill language continues to support the Clinical and Translational Science Awards Program as well as the follow - on to the National Children's Study.
The emphasis within the Center is on translational research studies that can enhance our understanding of the pathogenesis, presentation, and management of urologic diseases.
During my years at GSK I took on roles of increasing responsibility, and developed a strong background in MRI, image processing and analysis, as well as in the application of translational approaches to study neuropsychiatric brain disorders.
«The problem arises from autoimmunity, a condition that people with type 1 diabetes already have,» says Myra A. Lipes, M.D, investigator in the Section on Immunology at Joslin and principal investigator of a study published in the June 13 edition of the journal Science Translational Medicine.
The Clinical Accelerator, building on 60 + years of CRI's dedication to funding the most innovative basic science in tumor immunology, enables experts to advance their most ambitious clinical and translational research ideas to cure cancer, and accelerates studies that one group or company could not do alone.
Dr. Sonntag studies this concept on the molecular and cellular level using a translational research approach that integrates the analysis of human material, such as postmortem brains, primary cell systems, and neural cell populations generated from patients» - or healthy individuals» - derived induced pluripotent stem cells (iPSC), or induced neurons (iNs), in combination with molecular, biochemistry, and lentivirus - mediated gene - engineering technologies.
The second laboratory continues to focus attention on transplantation immunobiology in mouse models and translational studies of human immunology in transplant recipients.
Researchers from the group of Gary L. Dunbar at Central Michigan University, Michigan, USA have recently shown the ability of adenovirally generated rat iPSCs to survive and differentiate in the striatum of rats [6], and now in a study in Stem Cells Translational Medicine, they focus on the efficacy of transplantation of these cells into the 3 - nitropropionic acid (3 - NP) rat model of HD [7], which induces cell death by energy - depleting mechanisms providing an accurate model of cell loss and replicates many features of the disease [8].
The National Institutes of Health — including the National Institute on Aging, the Office of Women's Health Research, the Office of AIDS Research, the Office of Behavioral and Social Sciences Research — and the McHugh Otolaryngology Research Fund, the American Geriatrics Society, and the Institute of Translational Medicine at the University of Chicago funded the study.
Together, this translational program is developed within the National Cancer and Cognition Platform (CNO / Ligue Nationale contre le cancer), with the aim to collaborate in a structured way with French oncology groups, research teams as well as pharmaceutical industry, by providing preclinical models and guidance on standard operating procedures for ancillary or future studies in identified population at risk.
Two main examples of these translational studies we participated on can be exposed: The first Cog - Age clinical study (Pr F. Joly, Baclesse Caen) showed that cognitive decline can be detected 6 months after chemotherapy in breast cancer elderly patients.
I continue this line of research as such, and I currently am the principal investigator on multiple projects involving translational studies involving cell or gene therapy -.
In a study published Wednesday in the journal Science Translational Medicine, Chinese researchers detail a process by which a dedicated smartphone app is used to «switch on» engineered insulin - producing cells in mice.
This translational problem advocates for more refined studies on behavioral effects of drugs and perhaps better Alzheimer's models.
«Studies using optogenetics have the capacity to make an enormous impact on translational research,» she says.
«The current standard of care is clearly not sufficient, which highlights the urgent need for new therapeutic approaches,» said Saptarsi Haldar, MD, an associate investigator at Gladstone and senior author of a new study featured on the cover of the scientific journal Science Translational Medicine.
Cell Host & Microbe will publish novel findings related to microbes (which includes bacteria, fungi, parasites, and viruses) from molecular and cellular biology to translational studies with particular emphasis on the interface between the microbe and its host (vertebrate, invertebrate, or plant; unicellular or multicellular).
With ongoing studies in cancer care quality, outcomes prediction, clinical epidemiology, and medical decision making, we have a comprehensive portfolio of practice - and policy - relevant translational population sciences research in urologic cancers, building on the exceptional strengths of UNC Lineberger.
She is an international authority on IBD genetics and disease mechanisms and is leading efforts in developing novel translational approaches to study IBD.
Your study teams are empowered with up - to - date, accurate and actionable insights on biospecimen and related patient informed consent activities, boosting trial execution productivity while reducing operational and compliance risks for both ongoing trials and future translational medicine studies.
He has a particular emphasis on translational research, including the design of data - intensive, assay - rich clinical intervention and monitoring studies.
This study addresses the requirements of each of the four CPEBs for mitotic phase transitions, with a particular focus on cytoplasmic polyadenylation and translational regulation.
Funding provided by the Cancer Center Support Grant (CCSG) supports several types of pilot projects (1) highly innovative pilot projects focusing on proof - of - concept or translational research; (2) preliminary collaborative investigations that lead to multi-investigator grant awards or clinical trial; (3) projects that closely align with the Cancer Center's strategic plan and enhance key initiatives; and (4) pilot funding for junior investigators to jump - start independent projects or for more senior investigators looking to study a novel idea derived from discovery.
Alexandra Snyder, MD, is a translational physician scientist at Memorial Sloan Kettering Cancer Center (MSKCC) who specializes in the study of tumor genetics and response to checkpoint blockade immunotherapy in solid tumors, with a particular focus on ovarian cancer.
MicroRNA (Chandan Sen and Mingyu Liang, co-Section Editors): This section focuses on manuscripts that address all aspects of microRNA research including basic biology and translational and clinical studies.
Additional authors on this study are Lynne M. Ausman, D.Sc., professor at the Friedman School, Huicui Meng, Ph.D., postdoctoral associate in the Cardiovascular Nutrition Lab at the USDA HNRCA, and Hocine Tighiouart, M.S., statistical associate at the Tufts Clinical and Translational Science Institute and clinical assistant professor of medicine at Tufts University School of Medicine.
Oncology investigators in the NC State Center for Comparative Medicine and Translational Research, for example, focus on understanding the pathogenesis and treatment of cancer through studies involving, in part, spontaneous models of cancer provided by Terry Center oncology patients.
These include the latest clinical studies on emerging developments in renal medicine and the highest level of original research studies in therapy and epidemiology of acute and chronic kidney failure, as well as their translational aspects and genetic basis.