Sentences with phrase «on tumor blood vessels»

Disappointingly, the results of these experiments have shown that the most abundant antibody fragment that we isolated from our library does not appear to affect the interaction of VEGF with its receptor suggesting that this clone would not inhibit the biological effects of VEGF on tumor blood vessels.

Not exact matches

In the presence of these drugs tumors grow faster and develop more extensive networks of the blood vessels they rely on to feed their expansion — a process called angiogenesis, says Jonathan Moss, an anesthesiologist at the University of Chicago (U. of C.) Medical Center.

Patients received a tandem of lenalidomide, a drug that kills tumor cells, blocks blood vessel growth, and acts on the immune system, and dexamethasone, an anti-inflammatory agent, plus one of three new agents:

In this study, we found that chloroquine not only has an effect on the growth of the cancer cells, but also makes the tumor environment less aggressive by normalizing the abnormal blood vessels in the tumor,» says Patrizia Agostinis.

This blood vessel normalization results in an increased barrier function on the one hand — thereby blocking cancer cell dissemination and metastasis - and in enhanced tumor perfusion on the other hand, which increases the response of the tumor to chemotherapy.

One explanation for that, says Iacobuzio - Donahue, is that «Distant metastases have to travel long distances along the «highways» of the blood vessels, land in a good spot and colonize, while local metastases just pinch off the primary tumor and go a short distance on «familiar side roads,» so they are usually more similar to the primary tumor.»

However, the reality is that nanocarriers may not always reach their intended target in sufficient numbers because of a constraint on their ability to transit through the blood vessel wall at the tumor site, leading the encapsulated drugs to be diverted or lost before they can deliver their payload.

This helped to confirm that in addition to relying on leaky blood vessels for nanoparticles to gain access to the tumor, a major inducible vascular transit pathway is available in the form of the vesicle transport system.

The ability to enhance nanoparticle uptake is dependent on the level of expression of a molecule, called NRP - 1, to allow the peptide to bind to the tumor blood vessels.

They didn't develop tumors any faster than normal, and they didn't have any alterations in their blood vessels, which the researchers had anticipated based on BAI1's role in regulating blood vessel growth.

Cancer cells and tumors at first rely on nearby blood vessels to get what they need to survive, but, as tumors grow, they need to form new vessels.

Therefore, growing tumors rely on the simultaneous growth of capillaries, the fine branching blood vessels that form a supply network for them.

In an effort to overcome these limitations, a team at the Wyss Institute for Biologically Inspired Engineering led by its Founding Director, Donald Ingber, M.D., Ph.D., had previously engineered a microfluidic «Organ - on - a-Chip» (Organ Chip) culture device in which cells from a human intestinal cell line originally isolated from a tumor were cultured in one of two parallel running channels, separated by a porous matrix - coated membrane from human blood vessel - derived endothelial cells in the adjacent channel.

Once Pasqualini and Arap know which blood vessels a peptide latches on to, they can attach a drug to that peptide; in the case of cancer, the drug might destroy the vessels that feed a tumor.

Thalidomide's penchant for targeting blood vessels in tumors made Mummery wonder whether the drug's effect on angiogenesis could help HHT sufferers.

During open surgery, doctors rely on their sense of touch to identify the edges of hidden tumors and to locate hidden blood vessels and other anatomical structures: a procedure they call palpation.

Called «tumor microenvironments of metastasis,» these on - ramps are sites on blood vessels that special immune cells flock to.

Scientists could also use the printed tissue constructs to shed light on activities of living tissue that require complex architecture, such as wound healing, blood vessel growth, or tumor development.

Once the sensors have traveled into a tumor's leaky blood vessels, they use special targeting molecules to bind to receptors on the surface of blood vessel cells.

Some analyses have questioned whether the passive targeting strategy, which depends on the circulating medication slipping through the unique apertures of a tumor, is effective, noting that the blood vessels that spring up around tumors may not be as porous as originally thought, and therefore may prevent large quantities of the nanodrug from reaching its target.

Depending on characteristics such as how many tumor cells, blood vessel cells, and immune cells are touching each other, the tumor microenvironment can nearly triple the chance that a common type of breast cancer (estrogen - receptor positive / HER2 negative) that has reached the lymph nodes will also metastasize, Condeelis and colleagues showed in a 2014 study of 3,760 patients.

Tumors make too much VEGF in their haste to form blood vessels, which turns on the receptor complex.

According to recent research, the most common solid tumors (that is, cancer that occurs as clusters of cells in or on organs, rather than in liquid form within the blood or lymphatic system) have up to 66 mutations that influence how the cancer cells operate — how fast they divide, whether they are susceptible to the signals that would normally cause a cell to die, when they detach from the main tumor to colonize another organ in the body, when and where they attach blood vessels to healthy tissues.

She is institutional principal investigator of the Phase I Consortium Study in New Agents in Neuroblastoma Treatment and directs NIH - funded work on effects of SPARC (secreted protein acidic and rich in cysteine, an amino acid) on neuroblastoma tumor growth and blood vessel formation.

We also found that the EphB4 receptor expressed on the surface of breast cancer cells can promote tumor xenograft growth by enhancing blood vessel formation through interactions with its preferred ligand, ephrin - B2, present in tumor endothelial cells.

5/7/2007 Targeting Sugar on Blood Vessels May Inhibit Cancer Growth In a study that could point to novel therapies to prevent cancer spread, or metastasis, researchers at the University of California, San Diego (UCSD) School of Medicine have targeted a sugar that supports blood vessel growth in the tBlood Vessels May Inhibit Cancer Growth In a study that could point to novel therapies to prevent cancer spread, or metastasis, researchers at the University of California, San Diego (UCSD) School of Medicine have targeted a sugar that supports blood vessel growth in the tblood vessel growth in the tumor.

August 5, 2002 Gene therapy boosts cancer chemotherapy University of Chicago researchers have found a way to use cancer chemotherapy to turn on gene therapy designed to disrupt the growth of blood vessels to a tumor.

Since heterogeneity in the tumor microenvironment, such as the presence of a neighboring blood vessel, may drive genetic changes, he reasoned that it might also be reflected on the level of proteins.

The once - yearly exam can help eye doctors spot abnormal peeper problems, like a broken blood vessel or tumor that you're less likely to detect on your own.

Diagnosis of blood vessel disease is difficult and often relies on finding tumors in other parts of the body.

When heart - base tumors do cause symptoms, it is because they have grown large, and are pushing on the heart and major blood vessels.

A highly malignant cancer which preys on blood vessels, it can spread rapidly, causing tumors almost anywhere in the body.

That's directly contradicted by the information on the link you provided, which indicates that hydrazine causes tumors of the lungs, blood vessels, intenstines, etc..