Sentences with phrase «on tumor cell growth»

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As a cancer researcher, do you think the mechanisms of tumor growth are somehow changing to come into line with your perceptions, or is it possible that the process of our learning more about DNA mutations and cell architecture and nutrient exchange and epigenetic effects make it possible for us to inch ever closer to understanding that which is already going on under our noses?

Investigators focused on the tumor suppressor liver kinase B1 (LKB1), a protein that controls cell growth and metabolism.

A study analyzing brain tumor genomics on a single - cell level has found evidence that cancer stem cells fuel the growth of oligodendrogliomas, a slow - growing but incurable form of brain cancer.

Patients received a tandem of lenalidomide, a drug that kills tumor cells, blocks blood vessel growth, and acts on the immune system, and dexamethasone, an anti-inflammatory agent, plus one of three new agents:

In this study, we found that chloroquine not only has an effect on the growth of the cancer cells, but also makes the tumor environment less aggressive by normalizing the abnormal blood vessels in the tumor,» says Patrizia Agostinis.

«In drug development, it's easier to turn that growth function off than it is to switch on the cell's defective tumor suppression mechanism.»

Inhibition of transcription (blockade of water) on tumor suppressor genes, such as p21, leads to cell transformation (growth of the cactus - like eremophytes instead of normal plants from the drought).

About 20 percent of breast cancer patients have overexpressed growth receptors, known as Her2 + receptors, on the cancer cells, which cause uncontrolled tumor growth.

On the safety side, the panelists delved into the possible risks of injecting genetically modified cells into patients, including the potential for deadly viral infections, brain toxicity, and, paradoxically, the growth of new tumors brought about by CAR - T cells years after treatment.

Josef Singer and Judith Fazekas, both lead authors of the study, discovered that a receptor frequently found on human tumor cells (epidermal growth factor receptor or EGFR) is nearly 100 percent identical with the EGF receptor in dogs.

Since cancer cells bear very specific antigens on the surface, the corresponding antibodies bind to these molecules and thus inhibit tumor growth.

«We're looking for multiple mutations across tumors, mutations that turn on genes and promote cell growth,» Dias - Santagata says.

Understanding this in stem cells could further understanding on how these proteins are involved in tumor growth.

«Our experiments showed that restoring H19 expression hindered by too much p53 restored «protective differentiation» of osteoblasts to counter events of tumor growth early on in bone cancer,» said co-author, Ihor Lemischka, PhD, Director of The Black Family Stem Cell Institute within the Icahn School of Medicine.

Highly dependent on their estrogen receptors for growth and survival, these tumor cells are sensitive to hormonal therapies, making drugs like tamoxifen and fulvestrant effective first - line therapies for many patients.

LA JOLLA, CA — A tightly controlled system of checks and balances ensures that a powerful tumor suppressor called p53 keeps a tight lid on unchecked cell growth but doesn't wreak havoc...

LA JOLLA, CA — A tightly controlled system of checks and balances ensures that a powerful tumor suppressor called p53 keeps a tight lid on unchecked cell growth but doesn't wreak havoc in healthy cells.

A reverse situation can also happen; sometimes genes can be abnormally turned on by epigenetics, causing uncontrollable cell growth and the appearance of a tumor.

Injections of iPSC - EPCs did not however have significant effect on tumor growth or on overall survival, but transducing cells with a baculovirus expressing CD40L, a member of the TNF gene family which can induce apoptosis [6, 7], and injection into the breast cancer lung metastasis, increased levels of pro-apoptotic cytokines in lung tissues, indicating the induction of apoptosis by CD40L carried by the EPCs (See figure).

Runaway cell proliferation is driven by accelerators, or oncogenes, that are stuck on go — in collusion with broken brakes, or tumor suppressors, that can't control a tumor's pedal - to - the - metal growth.

To explore the biological function of DDX3 on cell growth control, a colony formation assay was done in several tumor cell lines (HuH - 7, HCT116, and HeLa) and normal murine fibroblast cells (NIH 3T3) under the selection of G418.

The glands lining the inner wall of the colon are the sites for most abnormal cell behavior such as uncontrolled cell growth, which results in polyps (non-cancerous growths) and later on in adenocarcinomas or tumors.

We also found that the EphB4 receptor expressed on the surface of breast cancer cells can promote tumor xenograft growth by enhancing blood vessel formation through interactions with its preferred ligand, ephrin - B2, present in tumor endothelial cells.

Harold Varmus: Well the simplistic way to think about that is and I'm not sure this is the way it will be worked out, is to be able to take just a few cells from those early lesions and examine them genetically or for other kinds of marks on the DNA that would predict whether or not this is some - this is a lesion which might or an early stage growth that might never be able to progress, but it is also possible that every early tumor of that kind has some probability of expanding and invading and growing to become a medical problem, so getting that right will obviously be crucial because it's very difficult to say when you've diagnosed something that is an early stage tumor that it won't progress.

Hunter's breakthrough, which set the story in motion, was a product of basic research on a chicken RNA tumor virus: the 1979 discovery of the first tyrosine kinase paved the way for our understanding of how cells perceive their environment and respond appropriately to growth signals.

The proliferation rates of the cancer in the flax - eaters were only half that of the controls, confirming the test - tube studies done on prostate cancer cells suggesting that flax can indeed slow prostate tumor growth.

Polyunsaturated fats such as corn oil and soybean oil are highly unstable and vulnerable to oxidation — and oxidation, in turn, is linked to cancer — while the omega - 6 fatty acids that predominate in vegetable oils have been shown to accelerate the growth of tumor cells.6 As Fallon and Enig explain, 4 excessive consumption of toxic polyunsaturated oils — not red meat — represents a known mechanism for colon cancer: «Colon cancer occurs when high levels of dietary vegetable oils and hydrogenated fats, along with certain carcinogens, are acted on by certain enzymes in the cells lining the colon, leading to tumor formation» [Emphasis added].

According to Lise Alschuler, author of the Definitive Guide To Cancer: An Integrative Approach to Prevention, Treatment, and Healing, studies on flax lignans demonstrate safety and efficacy in their use against breast cancer, «inhibiting the growth of human estrogen - dependent breast cancer cells in mice and strengthening the tumor - inhibitory effect of tamoxifen».

Cinnamon's effect on cancer cells and tumor growth has so far only been studied in animals, but was found to be toxic to cancer cells and to cause cancer cell death.

Skin Tumors: These tumors are a result of abnormal cell growth on a dog'sTumors: These tumors are a result of abnormal cell growth on a dog'stumors are a result of abnormal cell growth on a dog's skin.

Once they occur, mast cell tumors can quickly grow from small «skin tag» - like growths on the surface to the skin to invading full thickness of the skin, and progressing to the lymph nodes for systemic infection.

Most mast cell tumors are found on the skin and may be detected by a sudden swelling or growth.

So far this year, American Veterinarian ® has reported on immunotherapies that may slow growth or even shrink gliomas in dogs and humans, a liquid biopsy assessment tool to detect tumor cell mutation, and a shared study between the American Kennel Club Canine Health Foundation and the V Foundation for Cancer Research on the treatment of bladder cancer.